scholarly journals Inhibition of Human T-Cell Proliferation by Mammalian Target of Rapamycin (mTOR) Antagonists Requires Noncoding RNA Growth-Arrest-Specific Transcript 5 (GAS5)

2010 ◽  
Vol 78 (1) ◽  
pp. 19-28 ◽  
Author(s):  
Mirna Mourtada-Maarabouni ◽  
Anwar M. Hasan ◽  
Farzin Farzaneh ◽  
Gwyn T. Williams
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
Noncoding Rna ◽  
Mammalian Target Of Rapamycin ◽  
Growth Arrest ◽  
Target Of Rapamycin ◽  
T Cell Proliferation ◽  
Specific Transcript ◽  
Human T Cell

scholarly journals Naive CD4 T Cell Proliferation Is Controlled by Mammalian Target of Rapamycin Regulation of GRAIL Expression

2009 ◽  
Vol 182 (10) ◽  
pp. 5919-5928 ◽  
Author(s):  
Jack T. Lin ◽  
Neil B. Lineberry ◽  
Michael G. Kattah ◽  
Leon L. Su ◽  
Paul J. Utz ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
Mammalian Target Of Rapamycin ◽  
Cd4 T Cell ◽  
Target Of Rapamycin ◽  
T Cell Proliferation

scholarly journals Evidence of Immunosuppressive and Th2 Immune Polarizing Effects of Antidiabetic Momordica charantia Fruit Juice

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Rufine Fachinan ◽  
Adnette Fagninou ◽  
Magloire Pandoua Nekoua ◽  
Abdou Madjid Amoussa ◽  
Marius Adjagba ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
Fruit Juice ◽  
Momordica Charantia ◽  
T Cell Proliferation ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 2 ◽  
Human T Cell ◽  
Cell Proliferation And Differentiation

The mechanism of action of the antidiabetic capacity of Momordica charantia is still under investigation. Here, we assessed phytochemical compositions, antioxidant activity, and effects of total and filtered fruit and leafy stem juices of Momordica charantia on human T cell proliferation and differentiation through quantification of Th1/Th2 cytokines. In the absence of stimulation, total fruit and leafy stem juices induced significant T cell proliferation. Under PHA stimulation, both juices potentiated plant-induced T cell proliferation. However, the filtered fruit and leafy stem juices significantly inhibited PHA-stimulated T cell proliferation, while neither juice influenced T cell proliferation. Moreover, total and filtered fruit juice increased IL-4 secretion, while total and filtered leafy stem juice enhanced IFN-γ production. Phytochemical screening revealed the presence of tannins, flavonoids, anthocyans, steroids, and triterpenoids in both juices. Alkaloids, quinone derivatives, cardenolides, and cyanogenic derivatives were undetectable. The saponins present in total juices were undetectable after filtration. Moreover, both juices had appreciable antioxidant capacity. Our study supports the type 1 antidiabetic effect of filtered fruit juice of M. charantia which may be related to its immunosuppressive and T-helper 2 cell inducing capacities. Due to their immune-stimulatory activities and their ability to increase T-helper 1 cell cytokines, total fruit and leafy stem juices may serve in the treatment of immunodeficiency and certain infections.

Ouabain induces inhibition of the progression phase in human T-cell proliferation

1995 ◽  
Vol 165 (2) ◽  
pp. 246-253 ◽  
Author(s):  
Chaya Brodie ◽  
Atilla Tordai ◽  
Joachim Saloga ◽  
Joanne Domenico ◽  
Erwin W. Gelfand
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
T Cell Proliferation ◽  
Human T Cell

scholarly journals K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation

2011 ◽  
Vol 91 (3) ◽  
pp. 449-459 ◽  
Author(s):  
Tao Wang ◽  
Catherine Huang ◽  
Alfonso Lopez-Coral ◽  
Kimberly A. Slentz-Kesler ◽  
Min Xiao ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
Interferon Γ ◽  
T Cell Proliferation ◽  
Human T Cell

scholarly journals Statin Modulation of Human T-Cell Proliferation, IL-1 and IL-17 Production, and IFN- T Cell Expression: Synergy with Conventional Immunosuppressive Agents

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Ashmal Jameel ◽  
Kenneth G.-J. Ooi ◽  
Natasha R. Jeffs ◽  
Grazyna Galatowicz ◽  
Susan L. Lightman ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
Immunosuppressive Agents ◽  
Experimental Models ◽  
T Cell Proliferation ◽  
Reductase Inhibitors ◽  
Human T Cell ◽  
Human Immune ◽  
Cell Expression

HMG-CoA reductase inhibitors (statins) have been demonstrated to be immunomodulatory for human immune-mediated disease and in experimental models. The aim of this study was to compare statin-mediated immunosuppressive effects on human T-cell responsesin vitrowith those of conventional immunosuppressives (dexamethasone, cyclosporin A (CsA), mycophenolate, and rapamycin). Statins (atorvastatin, lovastatin, and simvastatin) were investigated for their modulatory effects on human PBMC viability, cytokine profiles, and T-cell proliferation. At concentrations that inhibited anti-CD3/28-stimulated T-cell proliferation (), simvastatin significantly decreased intracellular CD4+T-cell expression of IFN- () to levels similar to those induced by conventional immunosuppressives. Atorvastatin and lovastatin also decreased IFN- expression, although to a lesser degree (). All three statins reduced levels of IL-17 production (). However, in response to anti-CD3/28 stimulation, simvastatin significantly upregulated IL-1 production (). The profile of cytokines produced in response to anti-CD3/28 stimulation was similar when both atorvastatin and dexamethasone were added as compared with dexamethasone alone, suggesting that atorvastatin can synergise with dexamethasone with respect to immunomodulation of cytokines. This data supports the hypothesis of selective statin-mediated immunomodulatory effects on human immune cells.

Characterization of the Progression Signal for Human T-Cell Proliferation Provided by Monoclonal Antibodies to the CD3-TCR Complex

1993 ◽  
Vol 67 (3) ◽  
pp. 232-239 ◽  
Author(s):  
Joachim Saloga ◽  
Reinhard Schwinzer ◽  
Harald Renz ◽  
Naohiro Terada ◽  
Reuven Or ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Monoclonal Antibodies ◽  
T Cell ◽  
T Cell Proliferation ◽  
Human T Cell
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