Ligand-Mediated Regulation of Peroxisome Proliferator-Activated Receptor (PPAR) β/δ: A Comparative Analysis of PPAR-Selective Agonists and All-trans Retinoic Acid

2008 ◽  
Vol 74 (5) ◽  
pp. 1269-1277 ◽  
Author(s):  
Markus Rieck ◽  
Wolfgang Meissner ◽  
Simone Ries ◽  
Sabine Müller-Brüsselbach ◽  
Rolf Müller
Keyword(s):  
Retinoic Acid ◽  
Comparative Analysis ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Selective Agonists

scholarly journals Nuclear Receptors as Potential Therapeutic Targets for Myeloid Leukemia

Cells ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 1921
Author(s):  
Pan Pan ◽  
Xiao Chen
Keyword(s):  
Retinoic Acid ◽  
Myeloid Leukemia ◽  
Therapeutic Potential ◽  
Retinoic Acid Receptor ◽  
Therapeutic Targets ◽  
Leukemic Cells ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
All Trans Retinoic Acid ◽  
Research Findings

The nuclear receptor (NR) superfamily has been studied extensively in many solid tumors and some receptors have been targeted to develop therapies. However, their roles in leukemia are less clear and vary considerably among different types of leukemia. Some NRs participate in mediating the differentiation of myeloid cells, making them attractive therapeutic targets for myeloid leukemia. To date, the success of all-trans retinoic acid (ATRA) in treating acute promyelocytic leukemia (APL) remains a classical and unsurpassable example of cancer differentiation therapy. ATRA targets retinoic acid receptor (RAR) and forces differentiation and/or apoptosis of leukemic cells. In addition, ligands/agonists of vitamin D receptor (VDR) and peroxisome proliferator-activated receptor (PPAR) have also been shown to inhibit proliferation, induce differentiation, and promote apoptosis of leukemic cells. Encouragingly, combining different NR agonists or the addition of NR agonists to chemotherapies have shown some synergistic anti-leukemic effects. This review will summarize recent research findings and discuss the therapeutic potential of selected NRs in acute and chronic myeloid leukemia, focusing on RAR, VDR, PPAR, and retinoid X receptor (RXR). We believe that more mechanistic studies in this field will not only shed new lights on the roles of NRs in leukemia, but also further expand the clinical applications of existing therapeutic agents targeting NRs.

Antiproliferative effect of all-trans-retinoic acid in cholangiocarcinoma

2017 ◽  
Author(s):  
A Prawan ◽  
S Butsri ◽  
V Kukongviriyapan ◽  
L Senggunprai ◽  
S Kongpetch
Keyword(s):  
Retinoic Acid ◽  
Antiproliferative Effect ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid
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