Protease-Activated Receptor-1 Mediates Thrombin-Induced Persistent Sodium Current in Human Cardiomyocytes

2008 ◽  
Vol 73 (6) ◽  
pp. 1622-1631 ◽  
Author(s):  
Caroline Pinet ◽  
Vincent Algalarrondo ◽  
Sylvie Sablayrolles ◽  
Bruno Le Grand ◽  
Christophe Pignier ◽  
...  
Keyword(s):  
Sodium Current ◽  
Persistent Sodium Current ◽  
Human Cardiomyocytes ◽  
Protease Activated Receptor 1

Sodium Currents in Neurons From the Rostroventrolateral Medulla of the Rat

2003 ◽  
Vol 90 (3) ◽  
pp. 1635-1642 ◽  
Author(s):  
Ilya A. Rybak ◽  
Krzysztof Ptak ◽  
Natalia A. Shevtsova ◽  
Donald R. McCrimmon
Keyword(s):  
Sodium Channels ◽  
Sodium Current ◽  
Cell Voltage ◽  
Kinetic Properties ◽  
Persistent Sodium Current ◽  
Sodium Currents ◽  
Bötzinger Complex ◽  
Window Current ◽  
Bursting Activity

Rapidly inactivating and persistent sodium currents have been characterized in acutely dissociated neurons from the area of rostroventrolateral medulla that included the pre-Bötzinger Complex. As demonstrated in many studies in vitro, this area can generate endogenous rhythmic bursting activity. Experiments were performed on neonate and young rats (P1-15). Neurons were investigated using the whole cell voltage-clamp technique. Standard activation and inactivation protocols were used to characterize the steady-state and kinetic properties of the rapidly inactivating sodium current. Slow depolarizing ramp protocols were used to characterize the noninactivating sodium current. The “window” component of the rapidly inactivating sodium current was calculated using mathematical modeling. The persistent sodium current was revealed by subtraction of the window current from the total noninactivating sodium current. Our results provide evidence of the presence of persistent sodium currents in neurons of the rat rostroventrolateral medulla and determine voltage-gated characteristics of activation and inactivation of rapidly inactivating and persistent sodium channels in these neurons.

scholarly journals Y1767C, a Novel SCN5A Mutation Induces a Persistent Sodium Current and Potentiates Ranolazine Inhibition of NaV1.5 Channels

2011 ◽  
Vol 100 (3) ◽  
pp. 421a
Author(s):  
Hai Huang ◽  
Silvia G. Priori ◽  
Carlo Napolitano ◽  
Michael E. O’Leary ◽  
Mohamed Chahine
Keyword(s):  
Sodium Current ◽  
Persistent Sodium Current ◽  
Scn5a Mutation

Respiratory rhythm generation during gasping depends on persistent sodium current

2006 ◽  
Vol 9 (3) ◽  
pp. 311-313 ◽  
Author(s):  
Julian F R Paton ◽  
Ana P L Abdala ◽  
Hidehiko Koizumi ◽  
Jeffrey C Smith ◽  
Walter M St-John
Keyword(s):  
Sodium Current ◽  
Respiratory Rhythm ◽  
Persistent Sodium Current ◽  
Rhythm Generation ◽  
Respiratory Rhythm Generation
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