Topological Mapping of the Asymmetric Drug Binding to the Human Ether-à-go-go-Related Gene Product (HERG) Potassium Channel by Use of Tandem Dimers

2008 ◽  
Vol 73 (6) ◽  
pp. 1643-1651 ◽  
Author(s):  
Toshihiko Myokai ◽  
Sunghi Ryu ◽  
Hirofumi Shimizu ◽  
Shigetoshi Oiki
Keyword(s):  
Potassium Channel ◽  
Gene Product ◽  
Drug Binding ◽  
Related Gene ◽  
Topological Mapping

How to Fluorescently Label the Potassium Channel: A Case in hERG

2020 ◽  
Vol 27 (18) ◽  
pp. 3046-3054
Author(s):  
Xiaomeng Zhang ◽  
Beilei Wang ◽  
Zhenzhen Liu ◽  
Yubin Zhou ◽  
Lupei Du
Keyword(s):  
Potassium Channel ◽  
Herg Channel ◽  
Pore Channel ◽  
Design Rationale ◽  
Related Gene ◽  
Open Conformation ◽  
Cardiac Action ◽  
Qt Syndrome ◽  
Herg Channels ◽  
Action Potential Repolarization

hERG (Human ether-a-go-go-related gene) potassium channel, which plays an essential role in cardiac action potential repolarization, is responsible for inherited and druginduced long QT syndrome. Recently, the Cryo-EM structure capturing the open conformation of hERG channel was determined, thus pushing the study on hERG channel at 3.8 Å resolution. This report focuses primarily on summarizing the design rationale and application of several fluorescent probes that target hERG channels, which enables dynamic and real-time monitoring of potassium pore channel affinity to further advance the understanding of the channels.

Circadian changes of ether-a-go-go-related-gene (Erg) potassium channel transcripts in the rat pancreas and β-cell

2007 ◽  
Vol 64 (6) ◽  
pp. 768-780 ◽  
Author(s):  
E. Mühlbauer ◽  
I. Bazwinsky ◽  
S. Wolgast ◽  
A. Klemenz ◽  
E. Peschke
Keyword(s):  
Potassium Channel ◽  
Related Gene ◽  
Β Cell ◽  
Rat Pancreas ◽  
Circadian Changes

scholarly journals Comparative Effects of Liensinine and Neferine on the Human Ether-a-go-go-related Gene Potassium Channel and Pharmacological Activity Analysis

2012 ◽  
Vol 29 (3-4) ◽  
pp. 431-442 ◽  
Author(s):  
Zeng-Xiang Dong ◽  
Xin Zhao ◽  
Dong-Fang Gu ◽  
Yuan-Qi Shi ◽  
Jia Zhang ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Pharmacological Activity ◽  
Activity Analysis ◽  
Related Gene

Novel Mutation in Potassium Channel related Gene KCTD7 and Progressive Myoclonic Epilepsy

2012 ◽  
Vol 76 (4) ◽  
pp. 326-331 ◽  
Author(s):  
Birgit Krabichler ◽  
Kevin Rostasy ◽  
Matthias Baumann ◽  
Daniela Karall ◽  
Sabine Scholl-Bürgi ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Novel Mutation ◽  
Myoclonic Epilepsy ◽  
Related Gene ◽  
Progressive Myoclonic Epilepsy

scholarly journals Fluorogenic Probe for the Human Ether-a-Go-Go-Related Gene Potassium Channel Imaging

2015 ◽  
Vol 87 (5) ◽  
pp. 2550-2554 ◽  
Author(s):  
Zhenzhen Liu ◽  
Beilei Wang ◽  
Zhao Ma ◽  
Yubin Zhou ◽  
Lupei Du ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Related Gene ◽  
Fluorogenic Probe

scholarly journals Tyrosine Phosphorylation of RNA Polymerase II Carboxyl-terminal Domain by the Abl-related Gene Product

1997 ◽  
Vol 272 (30) ◽  
pp. 18905-18909 ◽  
Author(s):  
R. Baskaran ◽  
Gary G. Chiang ◽  
Tami Mysliwiec ◽  
Gary D. Kruh ◽  
Jean Y. J. Wang
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Tyrosine Phosphorylation ◽  
Gene Product ◽  
Related Gene ◽  
Terminal Domain ◽  
Carboxyl Terminal Domain ◽  
Carboxyl Terminal
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