Substance P Neurokinin 1 Receptor Activation within the Dorsal Raphe Nucleus Controls Serotonin Release in the Mouse Frontal Cortex

2007 ◽  
Vol 72 (6) ◽  
pp. 1411-1418 ◽  
Author(s):  
Bruno P. Guiard ◽  
Jean-Philippe Guilloux ◽  
Christelle Reperant ◽  
Stephen P. Hunt ◽  
Miklos Toth ◽  
...  
Keyword(s):  
Substance P ◽  
Frontal Cortex ◽  
Dorsal Raphe Nucleus ◽  
Receptor Activation ◽  
Dorsal Raphe ◽  
Serotonin Release ◽  
Raphe Nucleus ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1 ◽  
Dorsal Raphé

Trafficking of neurokinin-1 receptors in serotonin neurons is controlled by substance P within the rat dorsal raphe nucleus

2009 ◽  
Vol 29 (12) ◽  
pp. 2303-2314 ◽  
Author(s):  
Baptiste Lacoste ◽  
Mustapha Riad ◽  
Marc-Olivier Ratté ◽  
Sandra M. Boye ◽  
Daniel Lévesque ◽  
...  
Keyword(s):  
Substance P ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Serotonin Neurons ◽  
Neurokinin 1 ◽  
Dorsal Raphé

Effects of Acute or Chronic Administration of Anti-Migraine Drugs Sumatriptan and Zolmitriptan on Serotonin Synthesis in the Rat Brain

Cephalalgia ◽  
2004 ◽  
Vol 24 (1) ◽  
pp. 2-11 ◽  
Author(s):  
CF Dobson ◽  
Y Tohyama ◽  
M Diksic ◽  
E Hamel
Keyword(s):  
Rat Brain ◽  
Dorsal Raphe Nucleus ◽  
Chronic Administration ◽  
Brain Regions ◽  
Dorsal Raphe ◽  
Serotonin Release ◽  
Raphe Nucleus ◽  
Synthesis Rate ◽  
Regional Effects ◽  
Dorsal Raphé

Triptans are 5-HT1 receptor agonists used as anti-migraine drugs. They act primarily on meningeal blood vessels and on trigeminovascular afferents, but they may also exert central effects. We studied the regional effects of acute and chronic treatment with sumatriptan or zolmitriptan on the rate of serotonin (5-HT) synthesis in the rat brain, using the α-14C-methyl-L-tryptophan quantitative autoradiographic method. Sumatriptan at low (300 μg/kg, s.c.) and high (1 mg/kg) doses, as well as zolmitriptan (100 μg/kg), acutely decreased (15-40%, P < 0.05-0.001) 5-HT synthetic rate in many brain regions, including the dorsal raphe nucleus. Chronically, sumatriptan (21 days, approximately 300 μg/kg per day via osmotic minipumps) induced significant increases in the 5-HT synthesis rate in many projection areas but had no effect in the dorsal raphe nucleus. The acute effects on 5-HT synthesis rate would be compatible with activation of 5-HT1 autoreceptors that inhibit serotonin release. In contrast, the increased 5-HT synthesis rate observed after chronic sumatriptan might possibly result from a down-regulation/desensitization of 5-HT1 receptors and/or unmasking of excitatory triptan-sensitive 5-HT receptors. Overall, the present findings indicate that not only zolmitriptan but also sumatriptan affect brain serotonergic neurotransmission.

Pre-frontal cortex, dorsal raphe nucleus, 5-HT1a, 5-HT1b receptors and escalated aggression in rodents

2010 ◽  
Author(s):  
Rosa Maria de Almeida ◽  
C. P. Veiga ◽  
L. Centenaro ◽  
K. Vieira ◽  
A. B. Lucion ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Dorsal Raphé

scholarly journals Substance P (Neurokinin 1) Receptor Antagonists Enhance Dorsal Raphe Neuronal Activity

2002 ◽  
Vol 22 (17) ◽  
pp. 7730-7736 ◽  
Author(s):  
Rachel K. Conley ◽  
Michael J. Cumberbatch ◽  
Glenn S. Mason ◽  
David J. Williamson ◽  
Timothy Harrison ◽  
...  
Keyword(s):  
Substance P ◽  
Neuronal Activity ◽  
Dorsal Raphe ◽  
Receptor Antagonists ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1 ◽  
Dorsal Raphé
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