Vitamin D3 Derivatives with Adamantane or Lactone Ring Side Chains are Cell Type-Selective Vitamin D Receptor Modulators

2007 ◽  
Vol 71 (5) ◽  
pp. 1298-1311 ◽  
Author(s):  
Yuka Inaba ◽  
Keiko Yamamoto ◽  
Nobuko Yoshimoto ◽  
Manabu Matsunawa ◽  
Shigeyuki Uno ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Vitamin D3 ◽  
Lactone Ring ◽  
Side Chains ◽  
Cell Type ◽  
Receptor Modulators

Vitamin D Receptor (VDR) Allelic Variants Correlating with Response to Vitamin D3 Supplementation in Breast Cancer Survivors

2021 ◽  
pp. 1-14
Author(s):  
Elham Kazemian ◽  
Sayed Hossein Davoodi ◽  
Mohammad Esmaeil Akbari ◽  
Nariman Moradi ◽  
Safoora Gharibzadeh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Survivors ◽  
Vitamin D Receptor ◽  
Vitamin D3 ◽  
Breast Cancer Survivors ◽  
Allelic Variants ◽  
Vitamin D3 Supplementation

Identification of a highly potent vitamin D receptor antagonist: (25S)-26-Adamantyl-25-hydroxy-2-methylene-22,23-didehydro-19,27-dinor-20-epi-vitamin D3 (ADMI3)

2007 ◽  
Vol 460 (2) ◽  
pp. 240-253 ◽  
Author(s):  
Miharu Igarashi ◽  
Nobuko Yoshimoto ◽  
Keiko Yamamoto ◽  
Masato Shimizu ◽  
Michiyasu Ishizawa ◽  
...  
Keyword(s):  
Vitamin D ◽  
Receptor Antagonist ◽  
Vitamin D Receptor ◽  
Vitamin D3

scholarly journals Vitamin D3 induces vitamin D receptor and HDAC11 binding to relieve the promoter of the tight junction proteins

Oncotarget ◽  
2017 ◽  
Vol 8 (35) ◽  
pp. 58781-58789 ◽  
Author(s):  
Feng-Hua Liu ◽  
Shan-Shan Li ◽  
Xiao-Xi Li ◽  
Shuai Wang ◽  
Mao-Gang Li ◽  
...  
Keyword(s):  
Vitamin D ◽  
Tight Junction ◽  
Vitamin D Receptor ◽  
Vitamin D3 ◽  
Tight Junction Proteins ◽  
Junction Proteins

scholarly journals 25-Hydroxyvitamin D Inhibits Hepatitis C Virus Production in Hepatocellular Carcinoma Cell Line by a Vitamin D Receptor-Independent Mechanism

2019 ◽  
Vol 20 (9) ◽  
pp. 2367 ◽  
Author(s):  
Amiram Ravid ◽  
Noa Rapaport ◽  
Assaf Issachar ◽  
Arie Erman ◽  
Larisa Bachmetov ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Vitamin D Receptor ◽  
Vitamin D3 ◽  
Mode Of Action ◽  
Virus Production ◽  
Independent Manner ◽  
Hydroxyvitamin D ◽  
Independent Mechanism

Previously, we have reported that the active vitamin D metabolite, calcitriol and vitamin D3 (cholecalciferol), both remarkably inhibit hepatitis C virus production. The mechanism by which vitamin D3 exerts its effect is puzzling due to the low levels of calcitriol produced in vitamin D3-treated Huh7.5 cells. In this study, we aimed to explore the mechanism of vitamin D3 anti-hepatitis C virus effect. We show that vitamin D3 activity is not mediated by its metabolic conversion to calcitriol, but may be due to its primary metabolic product 25(OH)D3. This is inferred from the findings that 25(OH)D3 could inhibit hepatitis C virus production in our system, and that adequate concentrations needed to exert this effect are produced in Huh7.5 cells treated with vitamin D3. Using the CRISPR-Cas9 editing technology to knockout the vitamin D receptor, we found that the antiviral activity of vitamin D3 and 25(OH)D3 was not impaired in the vitamin D receptor knockout cells. This result indicates that 25(OH)D3 anti-hepatitis C virus effect is exerted by a vitamin D receptor-independent mode of action. The possibility that vitamin D3 and 25(OH)D3, being 3β-hydroxysteroids, affect hepatitis C virus production by direct inhibition of the Hedgehog pathway in a vitamin D receptor-independent manner was ruled out. Taken together, this study proposes a novel mode of action for the anti-hepatitis C virus activity of vitamin D3 that is mediated by 25(OH)D3 in a vitamin D receptor-independent mechanism.

Differential regulation of apolipoprotein A-I gene expression by vitamin D receptor modulators

2008 ◽  
Vol 1780 (2) ◽  
pp. 264-273 ◽  
Author(s):  
Kent R. Wehmeier ◽  
Angela Mazza ◽  
Sahar Hachem ◽  
Ken Ligaray ◽  
Arshag D. Mooradian ◽  
...  
Keyword(s):  
Gene Expression ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Differential Regulation ◽  
Apolipoprotein A ◽  
Receptor Modulators ◽  
I Gene
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