Coactivation of the Human Vitamin D Receptor by the Peroxisome Proliferator-Activated Receptor γ Coactivator-1 α

2005 ◽  
Vol 68 (2) ◽  
pp. 511-517 ◽  
Author(s):  
Rajesh S. Savkur ◽  
Kelli S. Bramlett ◽  
Keith R. Stayrook ◽  
Sunil Nagpal ◽  
Thomas P. Burris
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor

Inhibition of peroxisome proliferator-activated receptor α signaling by vitamin D receptor

2003 ◽  
Vol 312 (2) ◽  
pp. 513-519 ◽  
Author(s):  
Takahiro Sakuma ◽  
Takahide Miyamoto ◽  
Wei Jiang ◽  
Tomoko Kakizawa ◽  
Shin-ich Nishio ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor

Increased Body Mass Index but Not Common Vitamin D Receptor, Peroxisome Proliferator–Activated Receptor γ, or Cytokine Polymorphisms Confers Predisposition to Posttransplant Diabetes

2011 ◽  
Vol 135 (12) ◽  
pp. 1581-1584 ◽  
Author(s):  
Ping Wang ◽  
Elissa Hudspeth
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Body Mass ◽  
Vitamin D Receptor ◽  
Solid Organ Transplantation ◽  
Significant Risk ◽  
Peroxisome Proliferator ◽  
Solid Organ ◽  
Peroxisome Proliferator Activated Receptor

Context.—Posttransplant diabetes mellitus (PTDM) is a major complication after solid organ transplantation. The use of corticosteroids and calcineurin inhibitors, especially tacrolimus, are significant risk factors. However, it is not clear what genetic factors modify the risk. Evidence suggests vitamin D deficiency, perturbed glucose homeostasis, and increased inflammation all play roles in the development of diabetes. Objective.—To investigate whether common vitamin D receptor (VDR), cytokine, and peroxisome proliferator–activated receptor γ (PPARγ) polymorphisms are correlated with the development of PTDM. Design.—DNA was isolated from the peripheral blood of 51 kidney transplant recipients with PTDM and 72 patients without diabetes pretransplant or posttransplant at the time of follow-up. The genotypes for 5 polymorphisms, 1 each in VDR, PPARγ, INFγ, TGFβ1, and TNF, were determined using direct sequencing. Age, sex, number of acute rejection episodes, follow-up length, ethnicity, body mass index, and the frequency of alleles and genotypes for each polymorphism were compared between the 2 groups. Results.—Body mass index was the only factor that was statistically different between the 2 groups (P  =  .001). The frequency of different alleles and genotypes for each of the 5 polymorphisms did not differ between the 2 groups. Conclusions.—These results indicate that increased body mass index is a significant risk factor for the development of PTDM. However, none of the genetic polymorphisms studied confer predisposition to PTDM with the current sample size.

Methyl donor deficiency impairs bone development via peroxisome proliferator‐activated receptor‐γ coactivator‐1α–dependent vitamin D receptor pathway

2016 ◽  
Vol 30 (10) ◽  
pp. 3598-3612 ◽  
Author(s):  
Eva Feigerlova ◽  
Lea Demarquet ◽  
Hassan Melhem ◽  
Rose Ghemrawi ◽  
Shyue‐Fang Battaglia‐Hsu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Bone Development ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Methyl Donor

scholarly journals Hypovitaminosis D3, Leukopenia, and Human Serotonin Transporter Polymorphism in Anorexia Nervosa and Bulimia Nervosa

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Anna Tasegian ◽  
Francesco Curcio ◽  
Laura Dalla Ragione ◽  
Francesca Rossetti ◽  
Samuela Cataldi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Eating Disorders ◽  
Anorexia Nervosa ◽  
Bulimia Nervosa ◽  
Vitamin D Receptor ◽  
Vitamin D3 ◽  
Peroxisome Proliferator ◽  
Polymorphic Region ◽  
Peroxisome Proliferator Activated Receptor

Vitamin D3 has been described to have different extraskeletal roles by acting as parahormone in obesity, diabetes, cancer, cognitive impairment, and dementia and to have important regulatory functions in innate immunity. There are no studies showing extraskeletal changes associated with hypovitaminosis D3 in eating disorders.Methods.We have analyzed the blood of 18 patients affected by anorexia nervosa and bulimia nervosa collected over a 15-month period. We performed a panel of chemical and clinical analyses: the assay of vitamin D3, the immunoblotting of vitamin D receptor and peroxisome proliferator-activated receptor gamma, and the genotyping of 5-hydroxytryptamine transporter linked polymorphic region.Results.We choose 18 patients with a normal blood test profile such as thyroid hormones, hepatic and renal parameters, triglycerides, proteins, vitamin B12, and folic acid. Among these emerged the case of a woman with long-term anorexia nervosa and the case of a woman with long-term bulimia nervosa both complicated by anxiety and depression, severe hypovitaminosis D3, decrease of vitamin D receptor, leukopenia, and 5-hydroxytryptamine transporter linked polymorphic region short allele.Conclusion.The results induce hypothesising that the severe hypovitaminosis D3 might be responsible for the lack of the inflammatory response and the depressive symptoms in patients with long-term eating disorders.

Sign in / Sign up

Export Citation Format

Share Document