Differential Effects of Gqα, G14α, and G15α on Vascular Smooth Muscle Cell Survival and Gene Expression Profiles

2005 ◽  
Vol 67 (6) ◽  
pp. 2102-2114 ◽  
Author(s):  
Richard D. Peavy ◽  
Katherine B. Hubbard ◽  
Anthony Lau ◽  
R. Brett Fields ◽  
Kaiming Xu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Cell Survival ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Differential Effects

scholarly journals Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and increasing CX3CL1/CX3CR1 axis

2014 ◽  
Vol 103 (2) ◽  
pp. 324-336 ◽  
Author(s):  
Sergio Martínez-Hervás ◽  
Ángela Vinué ◽  
Laura Núñez ◽  
Irene Andrés-Blasco ◽  
Laura Piqueras ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Cell Survival ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell

scholarly journals Novel Pathological Role of hnRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) in Vascular Smooth Muscle Cell Function and Neointima Hyperplasia

2017 ◽  
Vol 37 (11) ◽  
pp. 2182-2194 ◽  
Author(s):  
Li Zhang ◽  
Qishan Chen ◽  
Weiwei An ◽  
Feng Yang ◽  
Eithne Margaret Maguire ◽  
...  
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Expression Levels ◽  
Heterogeneous Nuclear Ribonucleoprotein ◽  
Atherosclerotic Lesions ◽  
Nuclear Ribonucleoprotein

Objective— hnRNPA1 (heterogeneous nuclear ribonucleoprotein A1) plays a variety of roles in gene expression. However, little is known about the functional involvement of hnRNPA1 in vascular smooth muscle cell (VSMC) function and neointima hyperplasia. In this study, we have attempted to investigate the functional roles of hnRNPA1 in the contexts of VSMC function, injury-induced vessel remodeling, and human atherosclerotic lesions, as well as discern the molecular mechanisms involved. Approach and Results— hnRNPA1 expression levels were consistently modulated during VSMC phenotype switching and neointimal lesion formation induced by wire injury. Functional studies showed that VSMC-specific gene expression, proliferation, and migration were regulated by hnRNPA1. Our data show that hnRNPA1 exerts its effects on VSMC functions through modulation of IQGAP1 (IQ motif containing GTPase activating protein 1). Mechanistically, hnRNPA1 regulates IQGAP1 mRNA degradation through 2 mechanisms: upregulating microRNA-124 (miR-124) and binding to AU-rich element of IQGAP1 gene. Further evidence suggests that hnRNPA1 upregulates miR-124 by modulating miR-124 biogenesis and that IQGAP1 is the authentic target gene of miR-124. Importantly, ectopic overexpression of hnRNPA1 greatly reduced VSMC proliferation and inhibited neointima formation in wire-injured carotid arteries. Finally, lower expression levels of hnRNPA1 and miR-124, while higher expression levels of IQGAP1, were observed in human atherosclerotic lesions. Conclusions— Our data show that hnRNPA1 is a critical regulator of VSMC function and behavior in the context of neointima hyperplasia, and the hnRNPA1/miR-124/IQGAP1 regulatory axis represents a novel therapeutic target for the prevention of cardiovascular diseases.

scholarly journals A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage

2015 ◽  
Vol 27 (5) ◽  
pp. 923-933 ◽  
Author(s):  
Tessa M. Simone ◽  
Stephen P. Higgins ◽  
Jaclyn Archambeault ◽  
Craig E. Higgins ◽  
Roman G. Ginnan ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Cell Survival ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Small Molecule ◽  
Neointimal Hyperplasia ◽  
Pai 1
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