BLOOD-BRAIN BARRIER DRUG TARGETING: THE FUTURE OF BRAIN DRUG DEVELOPMENT

2003 ◽  
Vol 3 (2) ◽  
pp. 90-105 ◽  
Author(s):  
W. M. Pardridge
Keyword(s):  
Drug Development ◽  
Blood Brain Barrier ◽  
Drug Targeting ◽  
Brain Barrier ◽  
Blood Brain ◽  
The Future

scholarly journals Treatment of Alzheimer’s Disease and Blood–Brain Barrier Drug Delivery

2020 ◽  
Vol 13 (11) ◽  
pp. 394 ◽  
Author(s):  
William M. Pardridge
Keyword(s):  
Alzheimer’S Disease ◽  
Drug Delivery ◽  
Alzheimer's Disease ◽  
Drug Development ◽  
Blood Brain Barrier ◽  
New Drugs ◽  
Brain Barrier ◽  
Biologic Drugs ◽  
Blood Brain ◽  
Delivery Technology

Despite the enormity of the societal and health burdens caused by Alzheimer’s disease (AD), there have been no FDA approvals for new therapeutics for AD since 2003. This profound lack of progress in treatment of AD is due to dual problems, both related to the blood–brain barrier (BBB). First, 98% of small molecule drugs do not cross the BBB, and ~100% of biologic drugs do not cross the BBB, so BBB drug delivery technology is needed in AD drug development. Second, the pharmaceutical industry has not developed BBB drug delivery technology, which would enable industry to invent new therapeutics for AD that actually penetrate into brain parenchyma from blood. In 2020, less than 1% of all AD drug development projects use a BBB drug delivery technology. The pathogenesis of AD involves chronic neuro-inflammation, the progressive deposition of insoluble amyloid-beta or tau aggregates, and neural degeneration. New drugs that both attack these multiple sites in AD, and that have been coupled with BBB drug delivery technology, can lead to new and effective treatments of this serious disorder.

scholarly journals A Novel Blood-Brain Barrier Co-Culture System for Drug Targeting of Alzheimer’s Disease: Establishment by Using Acitretin as a Model Drug

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e91003 ◽  
Author(s):  
Christian Freese ◽  
Sven Reinhardt ◽  
Gudrun Hefner ◽  
Ronald E. Unger ◽  
C. James Kirkpatrick ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Brain Barrier ◽  
Drug Targeting ◽  
Culture System ◽  
Brain Barrier ◽  
Blood Brain ◽  
Model Drug

scholarly journals Potential applications of microfluidics based blood brain barrier (BBB)-on-chips for in vitro drug development

2020 ◽  
Vol 132 ◽  
pp. 110822 ◽  
Author(s):  
Xiaobo Wang ◽  
Ya Hou ◽  
Xiaopeng Ai ◽  
Jiayi Sun ◽  
Binjie Xu ◽  
...  
Keyword(s):  
Drug Development ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Potential Applications
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