Emerging Roles of TACE as a Key Protease in ErbB Ligand Shedding

2002 ◽  
Vol 2 (3) ◽  
pp. 136-141 ◽  
Author(s):  
P. J. Dempsey
Keyword(s):  
Ligand Shedding

scholarly journals Substrate Selectivity of Epidermal Growth Factor-Receptor Ligand Sheddases and their Regulation by Phorbol Esters and Calcium Influx

2007 ◽  
Vol 18 (1) ◽  
pp. 176-188 ◽  
Author(s):  
Keisuke Horiuchi ◽  
Sylvain Le Gall ◽  
Marc Schulte ◽  
Takafumi Yamaguchi ◽  
Karina Reiss ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Phorbol Esters ◽  
Calcium Influx ◽  
Growth Factor Receptor ◽  
Egfr Ligands ◽  
Egfr Ligand ◽  
Epidermal Growth ◽  
Ligand Shedding

Signaling via the epidermal growth factor receptor (EGFR), which has critical roles in development and diseases such as cancer, is regulated by proteolytic shedding of its membrane-tethered ligands. Sheddases for EGFR-ligands are therefore key signaling switches in the EGFR pathway. Here, we determined which ADAMs (a disintegrin and metalloprotease) can shed various EGFR-ligands, and we analyzed the regulation of EGFR-ligand shedding by two commonly used stimuli, phorbol esters and calcium influx. Phorbol esters predominantly activate ADAM17, thereby triggering a burst of shedding of EGFR-ligands from a late secretory pathway compartment. Calcium influx stimulates ADAM10, requiring its cytoplasmic domain. However, calcium influx-stimulated shedding of transforming growth factor α and amphiregulin does not require ADAM17, even though ADAM17 is essential for phorbol ester-stimulated shedding of these EGFR-ligands. This study provides new insight into the machinery responsible for EGFR-ligand release and thus EGFR signaling and demonstrates that dysregulated EGFR-ligand shedding may be caused by increased expression of constitutively active sheddases or activation of different sheddases by distinct stimuli.

Increase of CIK cell efficacy by upregulating cell surface MICA and inhibition of NKG2D ligand shedding in multiple myeloma

2016 ◽  
Vol 35 (4) ◽  
pp. 719-725 ◽  
Author(s):  
Chidimma A. Nwangwu ◽  
Hans Weiher ◽  
Ingo G. H. Schmidt-Wolf
Keyword(s):  
Multiple Myeloma ◽  
Cell Surface ◽  
Nkg2d Ligand ◽  
Cik Cell ◽  
Ligand Shedding

scholarly journals Targeting TACE-dependent EGFR ligand shedding in breast cancer

2007 ◽  
Vol 117 (2) ◽  
pp. 337-345 ◽  
Author(s):  
P. A. Kenny ◽  
M. J. Bissell
Keyword(s):  
Breast Cancer ◽  
Egfr Ligand ◽  
Ligand Shedding

scholarly journals NKG2D Ligand Shedding in Response to Stress: Role of ADAM10

2020 ◽  
Vol 11 ◽  
Author(s):  
Alessandra Zingoni ◽  
Elisabetta Vulpis ◽  
Luisa Loconte ◽  
Angela Santoni
Keyword(s):  
Nkg2d Ligand ◽  
Response To Stress ◽  
Ligand Shedding

scholarly journals Cisplatin-induced oxidative stress stimulates renal Fas ligand shedding

Renal Failure ◽  
2018 ◽  
Vol 40 (1) ◽  
pp. 314-322 ◽  
Author(s):  
Hitesh Soni ◽  
Damian Kaminski ◽  
Rajashekhar Gangaraju ◽  
Adebowale Adebiyi
Keyword(s):  
Oxidative Stress ◽  
Fas Ligand ◽  
Ligand Shedding

scholarly journals ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses

2017 ◽  
Vol 199 (7) ◽  
pp. 2305-2315 ◽  
Author(s):  
Joseph C. Lownik ◽  
Andrea J. Luker ◽  
Sheela R. Damle ◽  
Lauren Folgosa Cooley ◽  
Riham El Sayed ◽  
...  
Keyword(s):  
T Cell ◽  
B Cells ◽  
Follicular Helper ◽  
Ligand Shedding
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