scholarly journals Trovafloxacin Enhances Lipopolysaccharide-Stimulated Production of Tumor Necrosis Factor-α by Macrophages: Role of the DNA Damage Response

2014 ◽  
Vol 350 (1) ◽  
pp. 164-170 ◽  
Author(s):  
Kyle L. Poulsen ◽  
Jesus Olivero-Verbel ◽  
Kevin M. Beggs ◽  
Patricia E. Ganey ◽  
Robert A. Roth
Keyword(s):  
Dna Damage ◽  
Tumor Necrosis Factor ◽  
Dna Damage Response ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Damage Response ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Size-Dependent Effect of Silver Nanoparticles on the Tumor Necrosis Factor α-Induced DNA Damage Response

2019 ◽  
Vol 20 (5) ◽  
pp. 1038 ◽  
Author(s):  
Alaa Fehaid ◽  
Akiyoshi Taniguchi
Keyword(s):  
Dna Damage ◽  
Silver Nanoparticles ◽  
Tumor Necrosis Factor ◽  
Cell Surface ◽  
Dna Damage Response ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Damage Response ◽  
Factor Α ◽  
Necrosis Factor

Silver nanoparticles (AgNPs) are widely used in many consumer products due to their anti-inflammatory properties. Therefore, the effect of exposure to AgNPs should be investigated in diseased states in addition to healthy ones. Tumor necrosis factor-α (TNFα) is a major cytokine that is highly expressed in many diseased conditions, such as inflammatory diseases, sepsis, and cancer. We investigated the effects of two different sizes of AgNPs on the TNFα-induced DNA damage response. Cells were exposed to 10 and 200 nm AgNPs separately and the results showed that the 200 nm AgNPs had a lower cytotoxic effect with a higher percent of cellular uptake compared to the 10 nm AgNPs. Moreover, analysis of reactive oxygen species (ROS) generation and DNA damage indicated that TNFα-induced ROS-mediated DNA damage was reduced by 200 nm AgNPs, but not by 10 nm AgNPs. Tumor necrosis factor receptor 1 (TNFR1) was localized on the cell surface after TNFα exposure with or without 10 nm AgNPs. In contrast, the expression of TNFR1 on the cell surface was reduced by the 200 nm AgNPs. These results suggested that exposure of cells to 200 nm AgNPs reduces the TNFα-induced DNA damage response via reducing the surface expression of TNFR1, thus reducing the signal transduction of TNFα.

The Role of Tumor Necrosis Factor-α (TNF-α) Polymorphisms in Gastric Cancer: a Meta-Analysis

2021 ◽  
Author(s):  
Maryam Gholamalizadeh ◽  
Samaneh Mirzaei Dahka ◽  
Hadi Sedigh Ebrahim-Saraie ◽  
Mohammad Esmail Akbari ◽  
Azam Pourtaheri ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Meta Analysis ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Bidirectional Role of Tumor Necrosis Factor-α in Coronary Microembolization

2007 ◽  
Vol 100 (1) ◽  
pp. 140-146 ◽  
Author(s):  
Andreas Skyschally ◽  
Petra Gres ◽  
Simone Hoffmann ◽  
Michael Haude ◽  
Raimund Erbel ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Coronary Microembolization ◽  
Factor Α ◽  
Necrosis Factor
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