scholarly journals Modulation of Agonist Binding to AMPA Receptors by 1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine (CX546): Differential Effects across Brain Regions and GluA1–4/Transmembrane AMPA Receptor Regulatory Protein Combinations

2009 ◽  
Vol 331 (3) ◽  
pp. 965-974 ◽  
Author(s):  
Kyle E. Montgomery ◽  
Markus Kessler ◽  
Amy C. Arai
Keyword(s):  
Ampa Receptor ◽  
Ampa Receptors ◽  
Regulatory Protein ◽  
Brain Regions ◽  
Agonist Binding ◽  
Differential Effects

scholarly journals Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins

2003 ◽  
Vol 161 (4) ◽  
pp. 805-816 ◽  
Author(s):  
Susumu Tomita ◽  
Lu Chen ◽  
Yoshimi Kawasaki ◽  
Ronald S. Petralia ◽  
Robert J. Wenthold ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ampa Receptor ◽  
Ampa Receptors ◽  
Cerebellar Granule Cells ◽  
Surface Expression ◽  
Brain Regions ◽  
Regulatory Proteins ◽  
General Role ◽  
Receptor Complexes

Functional expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in cerebellar granule cells requires stargazin, a member of a large family of four-pass transmembrane proteins. Here, we define a family of transmembrane AMPA receptor regulatory proteins (TARPs), which comprise stargazin, γ-3, γ-4, and γ-8, but not related proteins, that mediate surface expression of AMPA receptors. TARPs exhibit discrete and complementary patterns of expression in both neurons and glia in the developing and mature central nervous system. In brain regions that express multiple isoforms, such as cerebral cortex, TARP–AMPA receptor complexes are strictly segregated, suggesting distinct roles for TARP isoforms. TARPs interact with AMPA receptors at the postsynaptic density, and surface expression of mature AMPA receptors requires a TARP. These studies indicate a general role for TARPs in controlling synaptic AMPA receptors throughout the central nervous system.

scholarly journals New Transmembrane AMPA Receptor Regulatory Protein Isoform,  -7, Differentially Regulates AMPA Receptors

2007 ◽  
Vol 27 (18) ◽  
pp. 4969-4977 ◽  
Author(s):  
A. S. Kato ◽  
W. Zhou ◽  
A. D. Milstein ◽  
M. D. Knierman ◽  
E. R. Siuda ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Ampa Receptors ◽  
Regulatory Protein ◽  
Protein Isoform

scholarly journals Amyloid-β-Induced Dysregulation of AMPA Receptor Trafficking

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Sumasri Guntupalli ◽  
Jocelyn Widagdo ◽  
Victor Anggono
Keyword(s):  
Glutamate Receptors ◽  
Ampa Receptor ◽  
Ampa Receptors ◽  
Molecular Mechanisms ◽  
Metabotropic Glutamate Receptor ◽  
Amyloid Β ◽  
Neuronal Loss ◽  
Brain Regions ◽  
Receptor Trafficking ◽  
Ampa Receptor Trafficking

Evidence from neuropathological, genetic, animal model, and biochemical studies has indicated that the accumulation of amyloid-beta (Aβ) is associated with, and probably induces, profound neuronal changes in brain regions critical for memory and cognition in the development of Alzheimer’s disease (AD). There is considerable evidence that synapses are particularly vulnerable to AD, establishing synaptic dysfunction as one of the earliest events in pathogenesis, prior to neuronal loss. It is clear that excessive Aβlevels can disrupt excitatory synaptic transmission and plasticity, mainly due to dysregulation of the AMPA and NMDA glutamate receptors in the brain. Importantly, AMPA receptors are the principal glutamate receptors that mediate fast excitatory neurotransmission. This is essential for synaptic plasticity, a cellular correlate of learning and memory, which are the cognitive functions that are most disrupted in AD. Here we review recent advances in the field and provide insights into the molecular mechanisms that underlie Aβ-induced dysfunction of AMPA receptor trafficking. This review focuses primarily on NMDA receptor- and metabotropic glutamate receptor-mediated signaling. In particular, we highlight several mechanisms that underlie synaptic long-term depression as common signaling pathways that are hijacked by the neurotoxic effects of Aβ.

scholarly journals Resensitizing AMPA receptors

2019 ◽  
Vol 152 (1) ◽  
Author(s):  
Ben Short
Keyword(s):  
Ampa Receptor ◽  
Ampa Receptors ◽  
Regulatory Protein ◽  
Ampa Receptor Channels

JGP study suggests how the regulatory protein γ8 reopens AMPA receptor channels in the continued presence of glutamate.

AMPA Receptor Antagonist CFM-2 Decreases Survivin Expression in Cancer Cells

2018 ◽  
Vol 18 (4) ◽  
pp. 591-596 ◽  
Author(s):  
Domingo Sanchez Ruiz ◽  
Hella Luksch ◽  
Marco Sifringer ◽  
Achim Temme ◽  
Christian Staufner ◽  
...  
Keyword(s):  
Cell Survival ◽  
Receptor Antagonist ◽  
Cancer Cells ◽  
Glutamate Receptors ◽  
Cancer Cell ◽  
Ampa Receptor ◽  
Ampa Receptors ◽  
Survivin Expression ◽  
Ampa Receptor Antagonist ◽  
Cancer Cell Survival

Background: Glutamate receptors are widely expressed in different types of cancer cells. α-Amino-3- hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors are ionotropic glutamate receptors which are coupled to intracellular signaling pathways that influence cancer cell survival, proliferation, and migration. Blockade of AMPA receptors by pharmacologic compounds may potentially constitute an effective tool in anticancer treatment strategies. Method: Here we investigated the impact of the AMPA receptor antagonist CFM-2 on the expression of the protein survivin, which is known to promote cancer cell survival and proliferation. We show that CFM-2 inhibits survivin expression at mRNA and protein levels and decreases the viability of cancer cells. Using a stably transfected cell line which overexpresses survivin, we demonstrate that over-expression of survivin enhances cancer cell viability and attenuates CFM-2–mediated inhibition of cancer cell growth. Result: These findings point towards suppression of survivin expression as a new mechanism contributing to anticancer effects of AMPA antagonists.

scholarly journals Structural landscape of isolated agonist-binding domains from single AMPA receptors

2011 ◽  
Vol 7 (3) ◽  
pp. 168-173 ◽  
Author(s):  
Christy F Landes ◽  
Anu Rambhadran ◽  
J Nick Taylor ◽  
Ferandre Salatan ◽  
Vasanthi Jayaraman
Keyword(s):  
Ampa Receptors ◽  
Agonist Binding ◽  
Binding Domains
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