(S)-1-(α-Naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD712) Reduces Rat Myocardial Apoptosis against Ischemia and Reperfusion Injury by Activation of Phosphatidylinositol 3-Kinase/Akt Signaling and Anti-inflammatory Action in Vivo

2009 ◽  
Vol 330 (2) ◽  
pp. 440-448 ◽  
Author(s):  
Yong Chun Jin ◽  
Young Soo Lee ◽  
Young Min Kim ◽  
Han Geuk Seo ◽  
Jae Heun Lee ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Akt Signaling ◽  
Ischemia And Reperfusion ◽  
Phosphatidylinositol 3 Kinase ◽  
Ischemia And Reperfusion Injury ◽  
Myocardial Apoptosis ◽  
Anti Inflammatory ◽  
Inflammatory Action ◽  
Phosphatidylinositol 3

scholarly journals Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 104
Author(s):  
Margarida Ferreira-Silva ◽  
Catarina Faria-Silva ◽  
Manuela C. Carvalheiro ◽  
Sandra Simões ◽  
Helena Susana Marinho ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Enhanced Recovery ◽  
Antioxidant Properties ◽  
Therapeutic Index ◽  
Drug Carriers ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury ◽  
Anti Inflammatory

Ischemia and reperfusion injury (IRI) is a common complication caused by inflammation and oxidative stress resulting from liver surgery. Current therapeutic strategies do not present the desirable efficacy, and severe side effects can occur. To overcome these drawbacks, new therapeutic alternatives are necessary. Drug delivery nanosystems have been explored due to their capacity to improve the therapeutic index of conventional drugs. Within nanocarriers, liposomes are one of the most successful, with several formulations currently in the market. As improved therapeutic outcomes have been demonstrated by using liposomes as drug carriers, this nanosystem was used to deliver quercetin, a flavonoid with anti-inflammatory and antioxidant properties, in hepatic IRI treatment. In the present work, a stable quercetin liposomal formulation was developed and characterized. Additionally, an in vitro model of ischemia and reperfusion was developed with a hypoxia chamber, where the anti-inflammatory potential of liposomal quercetin was evaluated, revealing the downregulation of pro-inflammatory markers. The anti-inflammatory effect of quercetin liposomes was also assessed in vivo in a rat model of hepatic IRI, in which a decrease in inflammation markers and enhanced recovery were observed. These results demonstrate that quercetin liposomes may provide a significant tool for addressing the current bottlenecks in hepatic IRI treatment.

scholarly journals Vagus Nerve Stimulation Alleviates Hepatic Ischemia and Reperfusion Injury by Regulating Glutathione Production and Transformation

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Haoyang Xia ◽  
Zhongzhong Liu ◽  
Wenjin Liang ◽  
Xianpeng Zeng ◽  
Yi Yang ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Reperfusion Injury ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Hepatic Function ◽  
Glutathione Synthetase ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury ◽  
Hepatic Ischemia

Inflammation and oxidative stress are pivotal mechanisms for the pathogenesis of ischemia and reperfusion injury (IRI). Vagus nerve stimulation (VNS) may participate in maintaining oxidative homeostasis and response to external stimulus or injury. We investigated whether the in vivo VNS can protect the liver from IRI. In this study, hepatic IRI were induced by ligating the vessels supplying the left and middle lobes of the liver, which underwent 1 h occlusion followed with 24 h reperfusion. VNS was initiated 15 min after ischemia and continued 30 min. Hepatic function, histology, and apoptosis rates were evaluated after 24 h reperfusion. Compared with the IRI group, VNS significantly improved hepatic function. The protective effect was accompanied by a reduction in histological damage in the ischemic area, and the apoptosis rate of hepatocytes has considerable reduction. To find the underlying mechanism, proteomic analysis was performed and differential expression of glutathione synthetase (GSS) and glutathione S-transferase (GST) was observed. Subsequently, test results indicated that VNS upregulated the expression of mRNA and protein of GSS and GST. Meanwhile, VNS increased the plasma levels of glutathione and glutathione peroxidases. We found that VNS alleviated hepatic IRI by upregulating the antioxidant glutathione via the GSS/glutathione/GST signaling pathway.

scholarly journals Protective effect and mechanistic evaluation of linalool against acute myocardial ischemia and reperfusion injury in rats

RSC Advances ◽  
2017 ◽  
Vol 7 (55) ◽  
pp. 34473-34481 ◽  
Author(s):  
Xiao-Hui Zheng ◽  
Chun-Ping Liu ◽  
Zeng-Guang Hao ◽  
Yan-Fang Wang ◽  
Xian-Li Li
Keyword(s):  
Cell Death ◽  
Myocardial Ischemia ◽  
Protective Effect ◽  
Reperfusion Injury ◽  
Acute Myocardial Ischemia ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury ◽  
Myocardial Ischemia And Reperfusion

Linalool causes attenuation of IR induced cell death and apoptosis eitherin vitroorin vivo.

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