Increased RhoA/Rho-Kinase Signaling Mediates Spontaneous Tone in Aorta from Angiotensin II-Induced Hypertensive Rats

2006 ◽  
Vol 318 (1) ◽  
pp. 288-295 ◽  
Author(s):  
Liming Jin ◽  
Zhekang Ying ◽  
Rob H. P. Hilgers ◽  
Jia Yin ◽  
Xueying Zhao ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Rho Kinase ◽  
Kinase Signaling ◽  
Hypertensive Rats ◽  
Spontaneous Tone

scholarly journals Interleukin-10 limits increased blood pressure and vascular RhoA/Rho-kinase signaling in angiotensin II-infused mice

Life Sciences ◽  
2016 ◽  
Vol 145 ◽  
pp. 137-143 ◽  
Author(s):  
Victor V. Lima ◽  
Saiprasad M. Zemse ◽  
Chin-Wei Chiao ◽  
Gisele F. Bomfim ◽  
Rita C. Tostes ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Rho Kinase ◽  
Interleukin 10 ◽  
Kinase Signaling

Effect of Early Normotension with Olmesartan on Rho-kinase Activity in Hypertensive Patients

2019 ◽  
Vol 18 (1) ◽  
pp. 87-91 ◽  
Author(s):  
Claudio Cantin ◽  
Jorge E. Jalil ◽  
Juan F. Bulnes ◽  
Ulises Novoa ◽  
Paul MacNab ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Kinase Activity ◽  
Clinical Evidence ◽  
Mononuclear Cells ◽  
Treatment Initiation ◽  
Rho Kinase ◽  
Angiotensin Ii Receptor ◽  
Peripheral Blood Mononuclear ◽  
Hypertensive Patients ◽  
Rock Activity

Background: Angiotensin II is a potent activator of the Rho-kinase (ROCK) pathway, through which it exerts some of its adverse vasoconstrictor effects. Clinical evidence on the effects of blocking the angiotensin II receptor 1 on ROCK activity in hypertensive patients is scarce. Objective: To demonstrate that ROCK activity in peripheral blood mononuclear cells (PMBCs) in patients with essential hypertension is reduced earlier than previously observed, along with blood pressure (BP) lowering on treatment with olmesartan. Methods: Prospective pilot open study; 17 hypertensive patients were treated with progressive olmesartan doses starting with 20 mg qd. BP was measured at 3, 6 and 9 weeks after treatment initiation. If treatment failed to normalize BP after 3 weeks, olmesartan dose was increased to 40 mg qd, and if still hypertensive after 6 weeks, 12.5 mg of hydrochlorothiazide qd was added. ROCK activity was measured at baseline and 9 weeks after treatment as myosin phosphatase target subunit 1 phosphorylation (MYPT1-p/T ratio) in PBMC. Results: Mean baseline BP was 162 ± 4.9/101 ± 2.4 mmHg. After 9 weeks of treatment, both systolic and diastolic BP were reduced by 41 and 22 mmHg, respectively (p<0.05). Mean pretreatment MYPT1- p/T ratio in PMBCs was significantly reduced by 80% after 9 weeks with olmesartan (p<0.01). Conclusion: Normotension achieved after 9 weeks in 82% of the patients treated with olmesartan was associated with a significant reduction of ROCK activity in PBMC.

Angiotensin II Increases Norepinephrine Turnover in the Anteroventral Third Ventricle of Spontaneously Hypertensive Rats

Hypertension ◽  
1996 ◽  
Vol 28 (2) ◽  
pp. 224-227 ◽  
Author(s):  
Akira Tsukashima ◽  
Takuya Tsuchihashi ◽  
Isao Abe ◽  
Kaoru Nakamura ◽  
Hideyuki Uchimura ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Spontaneously Hypertensive Rats ◽  
Third Ventricle ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Norepinephrine Turnover
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