Metabolism, Pharmacokinetics, and Excretion of a Highly SelectiveN-Methyl-d-aspartate Receptor Antagonist, Traxoprodil, in Human Cytochrome P450 2D6 Extensive and Poor Metabolizers

2003 ◽  
Vol 31 (1) ◽  
pp. 76-87 ◽  
Author(s):  
Kim Johnson ◽  
Ajit Shah ◽  
Sarah Jaw-Tsai ◽  
James Baxter ◽  
Chandra Prakash
Keyword(s):  
Cytochrome P450 ◽  
Receptor Antagonist ◽  
Poor Metabolizers ◽  
Cytochrome P450 2D6 ◽  
Aspartate Receptor ◽  
Human Cytochrome ◽  
P450 2D6

scholarly journals Crystal Structure of Human Cytochrome P450 2D6

2005 ◽  
Vol 281 (11) ◽  
pp. 7614-7622 ◽  
Author(s):  
Paul Rowland ◽  
Frank E. Blaney ◽  
Martin G. Smyth ◽  
Jo J. Jones ◽  
Vaughan R. Leydon ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Cytochrome P450 ◽  
Cytochrome P450 2D6 ◽  
Human Cytochrome ◽  
P450 2D6

Development of a V79 cell line expressing human cytochrome P450 2D6 and its application as a metabolic screening tool

1997 ◽  
Vol 3 (1) ◽  
pp. 31-39 ◽  
Author(s):  
Reimund Rauschenbach ◽  
Hille Gieschen ◽  
Birgit Salomon ◽  
Christian Kraus ◽  
Gerhard Kühne ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cell Line ◽  
Screening Tool ◽  
Cytochrome P450 2D6 ◽  
Human Cytochrome ◽  
Metabolic Screening ◽  
P450 2D6 ◽  
V79 Cell

scholarly journals Inhibition of Human Cytochrome P450 2D6 by Schering 66712

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Brendan Francis Butler ◽  
Jairam Palamanda ◽  
Amin A. Nomeir ◽  
F. Peter Guengerich ◽  
Laura Lowe Furge
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 2D6 ◽  
Human Cytochrome ◽  
P450 2D6
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