Accelerating clinical development of idasanutlin through a physiologically-based pharmacokinetic modeling risk assessment for CYP450 isoenzyme related drug-drug interactions

Drug Metabolism and Disposition ◽

10.1124/dmd.121.000720 ◽

2021 ◽

pp. DMD-AR-2021-000720

Author(s):

Kenichi Umehara ◽

Yumi Cleary ◽

Stephen Fowler ◽

Neil Parrott ◽

Dietrich W. Tuerck

Keyword(s):

Risk Assessment ◽

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Clinical Development ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Related Drug

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Physiologically Based Pharmacokinetic Modeling Approach to Predict Drug‐Drug Interactions With Ethionamide Involving Impact of Genetic Polymorphism on FMO3

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1378 ◽

2019 ◽

Vol 59 (6) ◽

pp. 880-889 ◽

Cited By ~ 1

Author(s):

Phuong Thi Thu Nguyen ◽

Md Masud Parvez ◽

Min Jung Kim ◽

Sung Eun Yoo ◽

Sangzin Ahn ◽

...

Keyword(s):

Genetic Polymorphism ◽

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Approach ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Risk Assessment of Predicted Serum Concentrations of Bisphenol A in Children and Adults Following Treatment with Dental Composite Restoratives, Dental Sealants, or Orthodontic Adhesives using Physiologically Based Pharmacokinetic Modeling

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2020.104839 ◽

2020 ◽

pp. 104839

Author(s):

Bradford D. Bagley ◽

Jordan N. Smith ◽

Justin G. Teeguarden

Keyword(s):

Risk Assessment ◽

Bisphenol A ◽

Pharmacokinetic Modeling ◽

Dental Composite ◽

Serum Concentrations ◽

Physiologically Based Pharmacokinetic Modeling ◽

Orthodontic Adhesives ◽

Physiologically Based Pharmacokinetic ◽

Dental Sealants ◽

Physiologically Based

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081030 (M10, B20) A tricholoethylene risk assessment using a Monte Carlo analysis of parameter uncertainty in conjunction with physiologically-based pharmacokinetic modeling

Insurance Mathematics and Economics ◽

10.1016/0167-6687(96)81409-0 ◽

1996 ◽

Vol 18 (2) ◽

pp. 140

Keyword(s):

Risk Assessment ◽

Monte Carlo ◽

Parameter Uncertainty ◽

Monte Carlo Analysis ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically based pharmacokinetic modeling to predict complex drug-drug interactions: a case study of AZD2327 and its metabolite, competitive and time-dependent CYP3A inhibitors

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.1962 ◽

2015 ◽

Vol 36 (8) ◽

pp. 507-519 ◽

Cited By ~ 4

Author(s):

Jian Guo ◽

Diansong Zhou ◽

Yan Li ◽

Bui H. Khanh

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Time Dependent ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Complex Drug

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Pain Chemogenomics Knowledgebase (Pain-CKB) for Systems Pharmacology Target Mapping and Physiologically Based Pharmacokinetic Modeling Investigation of Opioid Drug–Drug Interactions

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.0c00372 ◽

2020 ◽

Vol 11 (20) ◽

pp. 3245-3258

Author(s):

Mingzhe Shen ◽

Maozi Chen ◽

Tianjian Liang ◽

Siyi Wang ◽

Ying Xue ◽

...

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Systems Pharmacology ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Implementation of a Physiologically Based Pharmacokinetic Modeling Approach to Guide Optimal Dosing Regimens for Imatinib and Potential Drug Interactions in Paediatrics

Frontiers in Pharmacology ◽

10.3389/fphar.2019.01672 ◽

2020 ◽

Vol 10 ◽

Cited By ~ 2

Author(s):

Jeffry Adiwidjaja ◽

Alan V. Boddy ◽

Andrew J. McLachlan

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Potential Drug ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Approach ◽

Physiologically Based Pharmacokinetic ◽

Optimal Dosing ◽

Physiologically Based ◽

Dosing Regimens

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Physiologically‐Based Pharmacokinetic Modeling for Predicting Drug Interactions of a Combination of Olanzapine and Samidorphan

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12488 ◽

2020 ◽

Vol 9 (2) ◽

pp. 106-114 ◽

Cited By ~ 2

Author(s):

Lei Sun ◽

Lisa Moltke ◽

Karen Rowland Yeo

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Integration of Physiologically‐Based Pharmacokinetic Modeling into Early Clinical Development: An Investigation of the Pharmacokinetic Nonlinearity

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.35 ◽

2015 ◽

Vol 4 (5) ◽

pp. 286-294 ◽

Cited By ~ 1

Author(s):

L Zhou ◽

J Gan ◽

H Yoshitsugu ◽

X Gu ◽

JD Lutz ◽

...

Keyword(s):

Pharmacokinetic Modeling ◽

Clinical Development ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Early Clinical Development

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Physiologically based pharmacokinetic modeling of disposition and drug–drug interactions for atorvastatin and its metabolites

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2015.06.019 ◽

2015 ◽

Vol 77 ◽

pp. 216-229 ◽

Cited By ~ 18

Author(s):

Tao Zhang

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Prediction of Renal Transporter Mediated Drug-Drug Interactions for Pemetrexed Using Physiologically Based Pharmacokinetic Modeling

Drug Metabolism and Disposition ◽

10.1124/dmd.114.059618 ◽

2014 ◽

Vol 43 (3) ◽

pp. 325-334 ◽

Cited By ~ 36

Author(s):

Maria M. Posada ◽

James A. Bacon ◽

Karen B. Schneck ◽

Rommel G. Tirona ◽

Richard B. Kim ◽

...

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Renal Transporter

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