Investigation into MAO B-mediated formation of CC112273, a major circulating metabolite of ozanimod, in humans and preclinical species: Stereospecific oxidative deamination of (S)-enantiomer of indaneamine (RP101075) by MAO B

Stereospecific deuterium substitution at the α-carbon position of dopamine and its effect on oxidative deamination catalyzed by MAO-A and MAO-B from different tissues

Biochemical Pharmacology ◽

10.1016/0006-2952(86)90094-8 ◽

1986 ◽

Vol 35 (6) ◽

pp. 1027-1036 ◽

Cited By ~ 43

Author(s):

Peter H. Yu ◽

Bruce A. Bailey ◽

David A. Durden ◽

Alan A. Boulton

Keyword(s):

Oxidative Deamination ◽

Mao B ◽

Deuterium Substitution ◽

Mao A ◽

Different Tissues

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Monoamine Oxidases, Oxidative Stress, and Altered Mitochondrial Dynamics in Cardiac Ageing

Oxidative Medicine and Cellular Longevity ◽

10.1155/2017/3017947 ◽

2017 ◽

Vol 2017 ◽

pp. 1-8 ◽

Cited By ~ 28

Author(s):

Damien Maggiorani ◽

Nicola Manzella ◽

Dale E. Edmondson ◽

Andrea Mattevi ◽

Angelo Parini ◽

...

Keyword(s):

Mitochondrial Dynamics ◽

Scientific Evidence ◽

Mitochondrial Enzymes ◽

Oxidative Deamination ◽

Monoamine Oxidases ◽

Mao B ◽

The Past ◽

Age Dependent ◽

Mao A

The advances in healthcare over the past several decades have resulted in populations now living longer. With this increase in longevity, a wider prevalence of cardiovascular diseases is more common and known to be a major factor in rising healthcare costs. A wealth of scientific evidence has implicated cell senescence as an important component in the etiology of these age-dependent pathologies. A number of studies indicate that an excess of reactive oxygen species (ROS) contributes to trigger and accelerate the cardiac senescence processes, and a new role of monoamine oxidases, MAO-A and MAO-B, is emerging in this context. These mitochondrial enzymes regulate the level of catecholamines and serotonin by catalyzing their oxidative deamination in the heart. MAOs’ expression substantially increases with ageing (6-fold MAO-A in the heart and 4-fold MAO-B in neuronal tissue), and their involvement in cardiac diseases is supposedly related to the formation of ROS, via the hydrogen peroxide produced during the substrate degradation. Here, we will review the most recent advances in this field and describe why MAOs could be effective targets in order to prevent age-associated cardiovascular disease.

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The state of biogenic monoamine metabolism and processes of their oxidative deamination in patients with gastrocancerogenesis

Bukovinian Medical Herald ◽

10.24061/2413-0737.xviii.4.72.2014.179 ◽

2014 ◽

Vol 18 (4 (72)) ◽

Author(s):

I. M. Vasylieva ◽

E. A. Shevchenko ◽

Yu. A. Vinnyk ◽

V. I. Zhukov ◽

A. S. Tkachenko

Keyword(s):

Gastric Cancer ◽

Prognostic Significance ◽

Serum Levels ◽

Oxidative Deamination ◽

Biogenic Monoamines ◽

Mao B ◽

Platelet Mao ◽

Serum Ammonia ◽

Monoamines Metabolism ◽

Biogenic Monoamine

Biogenic monoamines metabolism and activity of oxidative deamination and their prognostic significance were investigated in patients with gastrocarcinogenesis. Investigation showed dynamic changes in serum levels of biogenic monoamines and activity of platelet MAO-B. Serum dopamine, epinephrine, norepinephrine, DOPA levels decreased, respectively, for II, III and IV stages of gastric cancer. An increase of serotonin and monoamine oxidase activity was observed. Analysis of obtained data showed inhibition of ergotropic body functions, activation of trophotropic processes and processes of biogenic amines deamination were observed in gastric cancer, which might be one of the major reasons for the accumulation of serum ammonia, aldehydes and peroxides-oxidizing agents and endotoxins.

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Some Aspects of the Oxidative Deamination of Tryptamine by MAO-A and MAO-B in Different Tissues

Neuropsychopharmacology of the Trace Amines ◽

10.1007/978-1-4612-5010-4_32 ◽

1985 ◽

pp. 301-308 ◽

Cited By ~ 1

Author(s):

P. H. Yu

Keyword(s):

Oxidative Deamination ◽

Mao B ◽

Mao A ◽

Different Tissues

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Dynamic hydrogels produced via monoamine oxidase B-catalyzed deamination and aldimine crosslinking for 3D printing

Journal of Materials Chemistry B ◽

10.1039/c7tb01108c ◽

2017 ◽

Vol 5 (26) ◽

pp. 5092-5095 ◽

Cited By ~ 7

Author(s):

Qingcong Wei ◽

Wei Xu ◽

Qi Zhang ◽

Shuang Zhang ◽

Liming Cheng ◽

...

Keyword(s):

3D Printing ◽

Monoamine Oxidase ◽

Monoamine Oxidase B ◽

Oxidative Deamination ◽

Mao B ◽

Deamination Reaction

Dynamic hydrogels of amino-containing polysaccharides (or proteins) and benzylamine-difunctionalized PEG were prepared via an oxidative deamination reaction catalyzed by MAO B.

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