The Effects of Traditional Chinese Medicine on P-Glycoprotein–Mediated Multidrug Resistance and Approaches for Studying the Herb–P-Glycoprotein Interactions

2020 ◽  
Vol 48 (10) ◽  
pp. 972-979 ◽  
Author(s):  
Yuhong Cao ◽  
Yiwei Shi ◽  
Ying Cai ◽  
Zhanying Hong ◽  
Yifeng Chai
Keyword(s):  
Multidrug Resistance ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
P Glycoprotein

Co-delivery of doxorubicin and the traditional Chinese medicine quercetin using biotin–PEG2000–DSPE modified liposomes for the treatment of multidrug resistant breast cancer

RSC Advances ◽  
2016 ◽  
Vol 6 (114) ◽  
pp. 113173-113184 ◽  
Author(s):  
Jiulong Zhang ◽  
Yue Luo ◽  
Xiufeng Zhao ◽  
Xiaowei Li ◽  
Kexin Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Chinese Medicine ◽  
Cancer Therapy ◽  
Traditional Chinese Medicine ◽  
Efflux Pump ◽  
Multidrug Resistant ◽  
Glycoprotein P ◽  
P Glycoprotein

At present, multidrug resistance (MDR) in cancer therapy is an international problem, which is caused mostly by the overexpressed P-glycoprotein (P-gp) efflux pump.

Cancer Treatment by Using Traditional Chinese Medicine: Probing Active Compounds in Anti-multidrug Resistance During Drug Therapy

2019 ◽  
Vol 25 (38) ◽  
pp. 5128-5141 ◽  
Author(s):  
Jian-Shu Lou ◽  
Ping Yao ◽  
Karl W.K. Tsim
Keyword(s):  
Multidrug Resistance ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cancer Treatment ◽  
Natural Compounds ◽  
In Vivo Studies ◽  
Standard Drug ◽  
Chemotherapy Drugs ◽  
Main Challenge

The main challenge of cancer treatment is multidrug resistance during chemotherapy. Cancer cell can evade cell death during every round of orthodox chemotherapy drugs, consequently being resistant after several rounds of standard drug treatment. One of the regimens to address this multidrug resistance problem is by drug combination. However, synthetic drugs always have problems of strong side effects and toxicity. Natural compounds deriving from traditional Chinese medicine are known to have low toxicity and genuine promising effects in reversing multidrug resistance, either induced by orthodox chemotherapeutic or targeted therapy drugs. Numerous mechanisms including suppression of drug efflux, detoxifying systems, DNA repair systems, and anti-apoptosis pathways were responsible for such process. A range of natural compounds functioned on the suppression of apoptosis are widely reported, which include flavonoids, terpenoids, alkaloids, quinones, xanthones, saponins and polysaccharides. Here, this review summarized comprehensive data from in vitro and in vivo studies to elucidate the functional roles of natural compounds in reversing multidrug resistance during cancer therapy.

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