Physiologically Based Pharmacokinetic Modeling of Bosentan Identifies the Saturable Hepatic Uptake As a Major Contributor to Its Nonlinear Pharmacokinetics

Masanobu Sato; Kota Toshimoto; Atsuko Tomaru; Takashi Yoshikado; Yuta Tanaka; Akihiro Hisaka; Wooin Lee; Yuichi Sugiyama

doi:10.1124/dmd.117.078972

Physiologically Based Pharmacokinetic Modeling of Bosentan Identifies the Saturable Hepatic Uptake As a Major Contributor to Its Nonlinear Pharmacokinetics

Drug Metabolism and Disposition ◽

10.1124/dmd.117.078972 ◽

2018 ◽

Vol 46 (5) ◽

pp. 740-748 ◽

Cited By ~ 9

Author(s):

Masanobu Sato ◽

Kota Toshimoto ◽

Atsuko Tomaru ◽

Takashi Yoshikado ◽

Yuta Tanaka ◽

...

Keyword(s):

Hepatic Uptake ◽

Pharmacokinetic Modeling ◽

Nonlinear Pharmacokinetics ◽

Major Contributor ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Predicting Nonlinear Pharmacokinetics of Omeprazole Enantiomers and Racemic Drug Using Physiologically Based Pharmacokinetic Modeling and Simulation: Application to Predict Drug/Genetic Interactions

Pharmaceutical Research ◽

10.1007/s11095-013-1293-z ◽

2014 ◽

Vol 31 (8) ◽

pp. 1919-1929 ◽

Cited By ~ 15

Author(s):

Fang Wu ◽

Lu Gaohua ◽

Ping Zhao ◽

Masoud Jamei ◽

Shiew-Mei Huang ◽

...

Keyword(s):

Modeling And Simulation ◽

Pharmacokinetic Modeling ◽

Genetic Interactions ◽

Nonlinear Pharmacokinetics ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Pharmacokinetic Modeling And Simulation

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Assessment and Confirmation of Species Difference in Nonlinear Pharmacokinetics of Atipamezole with Physiologically Based Pharmacokinetic Modeling

Drug Metabolism and Disposition ◽

10.1124/dmd.119.089151 ◽

2019 ◽

Vol 48 (1) ◽

pp. 41-51 ◽

Cited By ~ 1

Author(s):

Zheng Li ◽

You Gao ◽

Chunmiao Yang ◽

Yanan Xiang ◽

Wenpeng Zhang ◽

...

Keyword(s):

Species Difference ◽

Pharmacokinetic Modeling ◽

Nonlinear Pharmacokinetics ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically-based pharmacokinetic modeling of different size polyethylene glycol-coated gold nanoparticles in mice

10.1615/ihtc16.nmt.023362 ◽

2018 ◽

Author(s):

Linjing Deng ◽

Jinping Zhao ◽

Yufeng Miao ◽

Xu Hu ◽

Qihong Deng

Keyword(s):

Gold Nanoparticles ◽

Polyethylene Glycol ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically-Based Pharmacokinetic Modeling to Predict Changes in Drug Exposure during Pregnancy Using the Simcyp Simulator

10.26226/morressier.57d6b2b7d462b8028d88e945 ◽

2016 ◽

Author(s):

Suvarchala Kiranmai Avvari

Keyword(s):

Drug Exposure ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Exposure During Pregnancy

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Physiologically‐Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid‐to‐Lactone Conversion

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12447 ◽

2019 ◽

Vol 8 (9) ◽

pp. 664-675 ◽

Cited By ~ 5

Author(s):

Bridget L. Morse ◽

Jeffrey J. Alberts ◽

Maria M. Posada ◽

Jessica Rehmel ◽

Anil Kolur ◽

...

Keyword(s):

Gastric Emptying ◽

Delayed Gastric Emptying ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Preliminary physiologically based pharmacokinetic modeling of renally cleared drugs in Chinese pregnant women

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2243 ◽

2020 ◽

Vol 41 (6) ◽

pp. 248-267 ◽

Cited By ~ 1

Author(s):

Ling Song ◽

Zhiheng Yu ◽

Yifan Xu ◽

Xiaobei Li ◽

Xuanlin Liu ◽

...

Keyword(s):

Pregnant Women ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Prediction of fluoxetine and norfluoxetine pharmacokinetic profiles using physiologically based pharmacokinetic modeling

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1927 ◽

2021 ◽

Author(s):

Hyeon‐Cheol Jeong ◽

Yoon‐Jee Chae ◽

Sooyeun Lee ◽

Wonku Kang ◽

Hwi‐yeol Yun ◽

...

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Pharmacokinetic Profiles ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Modeling Approach to Predict Drug‐Drug Interactions With Ethionamide Involving Impact of Genetic Polymorphism on FMO3

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1378 ◽

2019 ◽

Vol 59 (6) ◽

pp. 880-889 ◽

Cited By ~ 1

Author(s):

Phuong Thi Thu Nguyen ◽

Md Masud Parvez ◽

Min Jung Kim ◽

Sung Eun Yoo ◽

Sangzin Ahn ◽

...

Keyword(s):

Genetic Polymorphism ◽

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Approach ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Modeling and Tissue Distribution Characteristics of SHetA2 in Tumor-Bearing Mice

The AAPS Journal ◽

10.1208/s12248-020-0421-z ◽

2020 ◽

Vol 22 (2) ◽

Author(s):

Ankur Sharma ◽

Mengjie Li ◽

Elangovan Thavathiru ◽

Mariam Ibrahim ◽

Lucila Garcia-Contreras ◽

...

Keyword(s):

Tissue Distribution ◽

Pharmacokinetic Modeling ◽

Distribution Characteristics ◽

Physiologically Based Pharmacokinetic Modeling ◽

Tumor Bearing ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Modeling of the Temperature-Dependent Dermal Absorption of Chloroform by Humans following Bath Water Exposures

Toxicological Sciences ◽

10.1093/toxsci/53.1.13 ◽

2000 ◽

Vol 53 (1) ◽

pp. 13-23 ◽

Cited By ~ 50

Author(s):

R. A. Corley

Keyword(s):

Pharmacokinetic Modeling ◽

Dermal Absorption ◽

Physiologically Based Pharmacokinetic Modeling ◽

Temperature Dependent ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Bath Water

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