scholarly journals Evaluation of Clinical Drug Interaction Potential of Clofazimine Using Static and Dynamic Modeling Approaches

2017 ◽  
Vol 46 (1) ◽  
pp. 26-32 ◽  
Author(s):  
Ramachandra Sangana ◽  
Helen Gu ◽  
Dung Yu Chun ◽  
Heidi J. Einolf
Keyword(s):  
Drug Interaction ◽  
Dynamic Modeling ◽  
Interaction Potential ◽  
Modeling Approaches ◽  
Clinical Drug

scholarly journals Clinical Drug-Drug Interaction Potential of BFE1224, Prodrug of Antifungal Ravuconazole, Using Two Types of Cocktails in Healthy Subjects

2018 ◽  
Vol 11 (5) ◽  
pp. 477-486 ◽  
Author(s):  
Yasuyuki Ishii ◽  
Yuko Ito ◽  
Shunji Matsuki ◽  
Kasumi Sanpei ◽  
Osamu Ogawa ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Interaction Potential ◽  
Healthy Subjects ◽  
Drug Drug Interaction ◽  
Clinical Drug

IN VITRO P-GLYCOPROTEIN INHIBITION ASSAYS FOR ASSESSMENT OF CLINICAL DRUG INTERACTION POTENTIAL OF NEW DRUG CANDIDATES: A RECOMMENDATION FOR PROBE SUBSTRATES

2006 ◽  
Vol 34 (5) ◽  
pp. 786-792 ◽  
Author(s):  
Jarkko Rautio ◽  
Joan E. Humphreys ◽  
Lindsey O. Webster ◽  
Anand Balakrishnan ◽  
John P. Keogh ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Interaction Potential ◽  
Drug Candidates ◽  
New Drug ◽  
P Glycoprotein ◽  
Glycoprotein Inhibition ◽  
Clinical Drug

scholarly journals Clinical Pharmacokinetic Drug Interaction Potential of MenoAct851 in Adult, Female Healthy Volunteers

2021 ◽  
Vol 94 ◽  
pp. 100619
Author(s):  
Vijayakumar Thangavel Mahalingam ◽  
Ilango Kaliappan ◽  
Satish Kumar Rajappan Chandra ◽  
Melvin George ◽  
Mohan Kumar Ramasamy ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Healthy Volunteers ◽  
Clinical Pharmacokinetic ◽  
Adult Female ◽  
Interaction Potential ◽  
Pharmacokinetic Drug Interaction ◽  
Pharmacokinetic Drug

scholarly journals Comprehensive PBPK Model to Predict Drug Interaction Potential of Zanubrutinib as a Victim or Perpetrator

2021 ◽  
Author(s):  
Kun Wang ◽  
Xueting Yao ◽  
Miao Zhang ◽  
Dongyang Liu ◽  
Yuying Gao ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Interaction Potential ◽  
Pbpk Model

scholarly journals No Effect of Digoxin on Rosuvastatin Pharmacokinetics in Healthy Subjects: Utility of Oita Combination for Clinical Drug–Drug Interaction Study

2019 ◽  
Vol 12 (5) ◽  
pp. 513-518 ◽  
Author(s):  
Naoyuki Otani ◽  
Hirokazu Wakuda ◽  
Hiromitsu Imai ◽  
Masae Kuranari ◽  
Yasuyuki Ishii ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Healthy Subjects ◽  
Interaction Study ◽  
Drug Interaction Study ◽  
Drug Drug Interaction ◽  
Clinical Drug

Framework for the Design of Cannabis-Mediated Phase I Drug-Drug Interaction Studies

2021 ◽  
Vol 16 ◽  
Author(s):  
Diana L. Shuster ◽  
Gina Pastino ◽  
Dirk Cerneus
Keyword(s):  
Drug Interaction ◽  
Drug Development ◽  
The United States ◽  
The Body ◽  
Cannabis User ◽  
Special Population ◽  
Care Providers ◽  
Clinical Drug Development ◽  
Drug Drug Interaction ◽  
Clinical Drug

: Cannabis has become legal in much of the United States similarly to many other countries, for either recreational or medical use. The use of cannabis products is rapidly increasing while the body of knowledge of its myriad of effects still lags. In vitro and clinical data show that cannabis’ main constituents, delta-9-tetrahydrocannabinol and cannabidiol, can affect the pharmacokinetics (PK), safety and pharmacodynamics (PD) of other drugs. Within the context of clinical drug development, the widespread and frequent use of cannabis products has essentially created another special population; that is, the cannabis user. We propose that all clinical drug development programs include a Phase 1 study to assess the drug-drug interaction potential of cannabis as a precipitant on the PK, safety and if applicable, the PD of all new molecular entities (NMEs) in a combination of healthy adult subjects as well as frequent and infrequent cannabis users. This data should be required to inform drug labeling and aid health care providers in treating any patient, as cannabis has quickly become another common concomitant medication and cannabis users, a new special population.

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