scholarly journals Correction to “Altered Hepatobiliary Disposition of Tolvaptan and Selected Tolvaptan Metabolites in a Rodent Model of Polycystic Kidney Disease”

2019 ◽  
Vol 47 (3) ◽  
pp. 328-328
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Rodent Model ◽  
Polycystic Kidney ◽  
Hepatobiliary Disposition

scholarly journals Altered Hepatobiliary Disposition of Tolvaptan and Selected Tolvaptan Metabolites in a Rodent Model of Polycystic Kidney Disease

2018 ◽  
Vol 47 (2) ◽  
pp. 155-163 ◽  
Author(s):  
James J. Beaudoin ◽  
Jacqueline Bezençon ◽  
Yanguang Cao ◽  
Katsuhiko Mizuno ◽  
Sharin E. Roth ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Rodent Model ◽  
Polycystic Kidney ◽  
Hepatobiliary Disposition

scholarly journals SAT-331 RENAL DENERVATION DOES NOT REDUCE BLOOD PRESSURE IN A RODENT MODEL OF POLYCYSTIC KIDNEY DISEASE

2019 ◽  
Vol 4 (7) ◽  
pp. S146
Author(s):  
S. Li ◽  
C.M. Hildreth ◽  
A.A. Rahman ◽  
V.J. Tallapragada ◽  
P.M. Pilowsky ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Renal Denervation ◽  
Reduce Blood Pressure ◽  
Rodent Model ◽  
Polycystic Kidney

751 TREATMENT WITH THE ANTIOXIDANT TEMPOL DOES NOT SIGNIFICANTLY AMELIORATE HYPERTENSION OR PROGRESSION OF RENAL DISEASE IN A RODENT MODEL OF POLYCYSTIC KIDNEY DISEASE

2012 ◽  
Vol 30 ◽  
pp. e217
Author(s):  
Jacqueline K. Phillips ◽  
Alice Ding ◽  
Priyadharshani Kalaignanasundaram ◽  
Sharon D. Ricardo ◽  
Amany Abdelkader ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Renal Disease ◽  
Polycystic Kidney Disease ◽  
Rodent Model ◽  
Polycystic Kidney ◽  
Progression Of Renal Disease

scholarly journals Renal denervation does not affect hypertension or the renin-angiotensin system in a rodent model of juvenile-onset polycystic kidney disease: clinical implications

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sheran Li ◽  
Cara M. Hildreth ◽  
Ahmed A. Rahman ◽  
Sean A. Barton ◽  
Benjamin F. Wyse ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Renal Denervation ◽  
Renin Angiotensin System ◽  
Rodent Model ◽  
Angiotensin Ii Receptor ◽  
Polycystic Kidney ◽  
Juvenile Onset ◽  
Angiotensin System ◽  
Renin Angiotensin

AbstractWe examined the effect of total and afferent renal denervation (RDN) on hypertension and the renin-angiotensin system (RAS) in a rodent model of juvenile-onset polycystic kidney disease (PKD). Lewis Polycystic Kidney (LPK) and control rats received total, afferent or sham RDN by periaxonal application of phenol, capsaicin or normal saline, respectively, and were monitored for 4-weeks. Afferent RDN did not affect systolic blood pressure (SBP) determined by radiotelemetry in either strain (n = 19) while total RDN significantly reduced SBP in Lewis rats 4-weeks post-denervation (total vs. sham, 122 ± 1 vs. 130 ± 2 mmHg, P = 0.002, n = 25). Plasma and kidney renin content determined by radioimmunoassay were significantly lower in LPK vs. Lewis (plasma: 278.2 ± 6.7 vs. 376.5 ± 11.9 ng Ang I/ml/h; kidney: 260.1 ± 6.3 vs. 753.2 ± 37.9 ng Ang I/mg/h, P < 0.001, n = 26). These parameters were not affected by RDN. Intrarenal mRNA expression levels of renin, angiotensinogen, angiotensin-converting enzyme (ACE)2, and angiotensin II receptor type 1a were significantly lower, whereas ACE1 expression was significantly higher in the LPK vs. Lewis (all P < 0.05, n = 26). This pattern of intrarenal RAS expression was not changed by RDN. In conclusion, RDN does not affect hypertension or the RAS in the LPK model and indicates RDN might not be a suitable antihypertensive strategy for individuals with juvenile-onset PKD.

scholarly journals Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease

2019 ◽  
Vol 47 (8) ◽  
pp. 899-906 ◽  
Author(s):  
Jacqueline Bezençon ◽  
James J. Beaudoin ◽  
Katsuaki Ito ◽  
Dong Fu ◽  
Sharin E. Roth ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Rodent Model ◽  
Polycystic Kidney ◽  
Altered Expression ◽  
Hepatic Transporters ◽  
And Function

Everolimus Retards Cyst Growth and Preserves Kidney Function in a Rodent Model for Polycystic Kidney Disease

2007 ◽  
Vol 30 (4) ◽  
pp. 253-259 ◽  
Author(s):  
Ming Wu ◽  
Patricia R. Wahl ◽  
Michel Le Hir ◽  
Ying Wäckerle-Men ◽  
Rudolf P. Wüthrich ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Kidney Function ◽  
Rodent Model ◽  
Polycystic Kidney ◽  
Cyst Growth

Protective cardiorenal effects of spironolactone in a rodent model of polycystic kidney disease

2015 ◽  
Vol 42 (4) ◽  
pp. 353-360 ◽  
Author(s):  
Thamarasee M Jeewandara ◽  
Omar Z Ameer ◽  
Rochelle Boyd ◽  
Benjamin F Wyse ◽  
Conor F Underwood ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Rodent Model ◽  
Polycystic Kidney

Cardiovascular autonomic dysfunction in a novel rodent model of polycystic kidney disease

2010 ◽  
Vol 152 (1-2) ◽  
pp. 60-66 ◽  
Author(s):  
Joanne L. Harrison ◽  
Cara M. Hildreth ◽  
Stephen M. Callahan ◽  
Ann K. Goodchild ◽  
Jacqueline K. Phillips
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Autonomic Dysfunction ◽  
Rodent Model ◽  
Polycystic Kidney ◽  
Cardiovascular Autonomic Dysfunction
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