scholarly journals Efflux Transport Characterization of Resveratrol Glucuronides in UDP-Glucuronosyltransferase 1A1 Transfected HeLa Cells: Application of a Cellular Pharmacokinetic Model to Decipher the Contribution of Multidrug Resistance-Associated Protein 4

2016 ◽  
Vol 44 (4) ◽  
pp. 485-488 ◽  
Author(s):  
S. Wang ◽  
F. Li ◽  
E. Quan ◽  
D. Dong ◽  
B. Wu
Keyword(s):  
Multidrug Resistance ◽  
Hela Cells ◽  
Pharmacokinetic Model ◽  
Efflux Transport ◽  
Udp Glucuronosyltransferase

scholarly journals Mechanism of the efflux transport of demethoxycurcumin-O-glucuronides in HeLa cells stably transfected with UDP-glucuronosyltransferase 1A1

PLoS ONE ◽  
2019 ◽  
Vol 14 (5) ◽  
pp. e0217695 ◽  
Author(s):  
Beibei Zhang ◽  
Jing Yang ◽  
Zifei Qin ◽  
Shishi Li ◽  
Jinjin Xu ◽  
...  
Keyword(s):  
Hela Cells ◽  
Efflux Transport ◽  
Udp Glucuronosyltransferase

scholarly journals Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat mRNA for UDP-glucuronosyltransferase.

1986 ◽  
Vol 261 (33) ◽  
pp. 15607-15614 ◽  
Author(s):  
T Iyanagi ◽  
M Haniu ◽  
K Sogawa ◽  
Y Fujii-Kuriyama ◽  
S Watanabe ◽  
...  
Keyword(s):  
Udp Glucuronosyltransferase

scholarly journals Characterization of RarA, a Novel AraC Family Multidrug Resistance Regulator in Klebsiella pneumoniae

2012 ◽  
Vol 56 (8) ◽  
pp. 4450-4458 ◽  
Author(s):  
Mark Veleba ◽  
Paul G. Higgins ◽  
Gerardo Gonzalez ◽  
Harald Seifert ◽  
Thamarai Schneiders
Keyword(s):  
Multidrug Resistance ◽  
Klebsiella Pneumoniae ◽  
Efflux Pump ◽  
Content Type ◽  
Resistance Phenotype ◽  
Serratia Proteamaculans ◽  
Virulence Potential ◽  
Article Type ◽  
Acrab Efflux Pump

ABSTRACTTranscriptional regulators, such as SoxS, RamA, MarA, and Rob, which upregulate the AcrAB efflux pump, have been shown to be associated with multidrug resistance in clinically relevant Gram-negative bacteria. In addition to the multidrug resistance phenotype, these regulators have also been shown to play a role in the cellular metabolism and possibly the virulence potential of microbial cells. As such, the increased expression of these proteins is likely to cause pleiotropic phenotypes.Klebsiella pneumoniaeis a major nosocomial pathogen which can express the SoxS, MarA, Rob, and RamA proteins, and the accompanying paper shows that the increased transcription oframAis associated with tigecycline resistance (M. Veleba and T. Schneiders, Antimicrob. Agents Chemother. 56:4466–4467, 2012). Bioinformatic analyses of the availableKlebsiellagenome sequences show that an additional AraC-type regulator is encoded chromosomally. In this work, we characterize this novel AraC-type regulator, hereby called RarA (Regulator of antibiotic resistance A), which is encoded inK. pneumoniae,Enterobactersp. 638,Serratia proteamaculans568, andEnterobacter cloacae. We show that the overexpression ofrarAresults in a multidrug resistance phenotype which requires a functional AcrAB efflux pump but is independent of the other AraC regulators. Quantitative real-time PCR experiments show thatrarA(MGH 78578 KPN_02968) and its neighboring efflux pump operonoqxAB(KPN_02969_02970) are consistently upregulated in clinical isolates collected from various geographical locations (Chile, Turkey, and Germany). Our results suggest thatrarAoverexpression upregulates theoqxABefflux pump. Additionally, it appears thatoqxR, encoding a GntR-type regulator adjacent to theoqxABoperon, is able to downregulate the expression of theoqxABefflux pump, where OqxR complementation resulted in reductions to olaquindox MICs.

scholarly journals Reversal Effects of Antifungal Drugs on Multidrug Resistance in MDR1-Overexpressing HeLa Cells

2001 ◽  
Vol 24 (9) ◽  
pp. 1032-1036 ◽  
Author(s):  
Nami IIDA ◽  
Kohji TAKARA ◽  
Nobuko OHMOTO ◽  
Tsutomu NAKAMURA ◽  
Takashi KIMURA ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Hela Cells ◽  
Antifungal Drugs

scholarly journals Isolation and Characterization of Teichoic Acid-Like Substance as an Adhesin ofStaphylococcus aureusto HeLa Cells

1996 ◽  
Vol 40 (4) ◽  
pp. 247-254 ◽  
Author(s):  
Takashi Matsuura ◽  
Yoichiro Miyake ◽  
Seiji Nakashima ◽  
Hitoshi Komatsuzawa ◽  
Yasumasa Akagawa ◽  
...  
Keyword(s):  
Hela Cells ◽  
Teichoic Acid ◽  
Isolation And Characterization
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