Metabolism and Pharmacokinetics of 3-n-Butylphthalide (NBP) in Humans: The Role of Cytochrome P450s and Alcohol Dehydrogenase in Biotransformation

2012 ◽  
Vol 41 (2) ◽  
pp. 430-444 ◽  
Author(s):  
Xingxing Diao ◽  
Pan Deng ◽  
Cen Xie ◽  
Xiuli Li ◽  
Dafang Zhong ◽  
...  
Keyword(s):  
Alcohol Dehydrogenase ◽  
Cytochrome P450s

scholarly journals The Role of Zinc in Alcohol Dehydrogenase

1959 ◽  
Vol 234 (10) ◽  
pp. 2621-2626 ◽  
Author(s):  
Bert L. Vallee ◽  
Robert J.P. Williams ◽  
Frederic L. Hoch
Keyword(s):  
Alcohol Dehydrogenase

scholarly journals The role of hepatic cytochrome P450s in the cytotoxicity of sertraline

2020 ◽  
Vol 94 (7) ◽  
pp. 2401-2411 ◽  
Author(s):  
Si Chen ◽  
Qiangen Wu ◽  
Xilin Li ◽  
Dongying Li ◽  
Michelle Fan ◽  
...  
Keyword(s):  
Cytochrome P450s ◽  
Hepatic Cytochrome

Model Complexes Elucidate the Role of the Proximal Hydrogen-Bonding Network in Cytochrome P450s

2020 ◽  
Vol 59 (12) ◽  
pp. 8034-8043
Author(s):  
Andrew P. Hunt ◽  
Subhra Samanta ◽  
Matthew R. Dent ◽  
Michael W. Milbauer ◽  
Judith N. Burstyn ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Cytochrome P450s ◽  
Model Complexes ◽  
Hydrogen Bonding Network

scholarly journals Purification and partial characterization of a rat retina alcohol dehydrogenase active with ethanol and retinol

1983 ◽  
Vol 213 (2) ◽  
pp. 547-550 ◽  
Author(s):  
P Julià ◽  
J Farrés ◽  
X Parés
Keyword(s):  
Alcohol Dehydrogenase ◽  
Partial Characterization ◽  
Visual Cycle ◽  
Rat Retina

Homogeneous alcohol dehydrogenase (ADH) from rat retina was obtained by chromatography on DEAE-Sepharose and AMP-hexane-Sepharose. The enzyme is a dimer of Mr congruent to 80000 and oxidizes ethanol using NAD+ as a cofactor. Careful activity determinations demonstrate unambiguously that rat retina ADH is active with retinol as a substrate. This result opens the question about the role of retina ADH in the visual cycle.

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