Evaluation of Metabolism and Disposition of GDC-0152 in Rats Using 14C Labeling Strategy at Two Different Positions: A Novel Formation of Hippuric Acid from 4-Phenyl-5-Amino-1,2,3-Thiadiazole

2012 ◽  
Vol 41 (2) ◽  
pp. 508-517 ◽  
Author(s):  
Qin Yue ◽  
Teresa Mulder ◽  
Patrick J. Rudewicz ◽  
Eric Solon ◽  
Nageshwar Budha ◽  
...  
Keyword(s):  
Hippuric Acid ◽  
14C Labeling

VANILLINSÄURE ALS ENDPRODUKT DES STOFFWECHSELS VON ADRENALIN UND NORADRENALIN. II.

1963 ◽  
Vol 44 (1) ◽  
pp. 101-106 ◽  
Author(s):  
Wilhelm Dirscherl ◽  
Helmut Thomas
Keyword(s):  
Rat Liver ◽  
Paper Chromatography ◽  
Column Chromatography ◽  
Vanillic Acid ◽  
Hippuric Acid ◽  
Single Spot ◽  
Solvent Systems ◽  
Perfusion Experiment ◽  
Kinetics Of

ABSTRACT Perfusion of rat liver with vanillic acid yielded only one metabolite. In paper chromatography with three different solvent systems, the substance showed the same RF-values as vanillyolglycine (3-methoxy-4-hydroxyhippuric acid) and in mixed chromatograms there was only one single spot. After separation by column chromatography, the UV- and IRspectra of the reaction product were identical with those of 3-methoxy4-hydroxy-hippuric acid. During the perfusion experiment, the kinetics of the conjugation were investigated.

ALDH2 Genetic Polymorphism and Urinary Hippuric Acid Concentration in Toluene Exposed Workers

1997 ◽  
Vol 9 (2) ◽  
pp. 332
Author(s):  
Oh Choon Kwon ◽  
Ree Joo ◽  
Jung Jeung Lee ◽  
Chang Yoon Kim ◽  
Jong Hak Chung ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Acid Concentration ◽  
Hippuric Acid ◽  
Exposed Workers

scholarly journals Use of urinary hippuric acid and o-/p-/m-methyl hippuric acid to evaluate surgical smoke exposure in operating room healthcare personnel

2021 ◽  
Vol 217 ◽  
pp. 112231
Author(s):  
Chun-Hui Chiu ◽  
Chi-Tsung Chen ◽  
Ming-Huei Cheng ◽  
Li-Heng Pao ◽  
Chi Wang ◽  
...  
Keyword(s):  
Operating Room ◽  
Hippuric Acid ◽  
Smoke Exposure ◽  
Healthcare Personnel ◽  
Surgical Smoke

scholarly journals Metabolites Secreted by Bovine Embryos In Vitro Predict Pregnancies That the Recipient Plasma Metabolome Cannot, and Vice Versa

Metabolites ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 162
Author(s):  
Enrique Gomez ◽  
Nuria Canela ◽  
Pol Herrero ◽  
Adrià Cereto ◽  
Isabel Gimeno ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Stearic Acid ◽  
Palmitic Acid ◽  
Hippuric Acid ◽  
Culture Media ◽  
Capric Acid ◽  
Glyceryl Monostearate ◽  
Invasive Approach ◽  
Hydrocinnamic Acid

This work describes the use of mass spectrometry-based metabolomics as a non-invasive approach to accurately predict birth prior to embryo transfer (ET) starting from embryo culture media and plasma recipient. Metabolomics was used here as a predictive platform. Day-6 in vitro produced embryos developed singly in modified synthetic oviduct fluid culture medium (CM) drops for 24 h were vitrified as Day-7 blastocysts and transferred to recipients. Day-0 and Day-7 recipient plasma (N = 36 × 2) and CM (N = 36) were analyzed by gas chromatography coupled to the quadrupole time of flight mass spectrometry (GC-qTOF). Metabolites quantified in CM and plasma were analyzed as a function to predict pregnancy at Day-40, Day-62, and birth (univariate and multivariate statistics). Subsequently, a Boolean matrix (F1 score) was constructed with metabolite pairs (one from the embryo, and one from the recipient) to combine the predictive power of embryos and recipients. Validation was performed in independent cohorts of ETs analyzed. Embryos that did not reach birth released more stearic acid, capric acid, palmitic acid, and glyceryl monostearate in CM (i.e., (p < 0.05, FDR < 0.05, Receiver Operator Characteristic—area under curve (ROC-AUC)> 0.669). Within Holstein recipients, hydrocinnamic acid, alanine, and lysine predicted birth (ROC-AUC > 0.778). Asturiana de los Valles recipients that reached birth showed lower concentrations of 6-methyl-5-hepten-2-one, stearic acid, palmitic acid, and hippuric acid (ROC-AUC > 0.832). Embryonal capric acid and glyceryl-monostearate formed F1 scores generally >0.900, with metabolites found both to differ (e.g., hippuric acid, hydrocinnamic acid) or not (e.g., heptadecanoic acid, citric acid) with pregnancy in plasmas, as hypothesized. Efficient lipid metabolism in the embryo and the recipient can allow pregnancy to proceed. Changes in phenolics from plasma suggest that microbiota and liver metabolism influence the pregnancy establishment in cattle.

Sign in / Sign up

Export Citation Format

Share Document