scholarly journals Quantitative Proteomics of Transporter Expression in Brain Capillary Endothelial Cells Isolated from P-Glycoprotein (P-gp), Breast Cancer Resistance Protein (Bcrp), and P-gp/Bcrp Knockout Mice

2012 ◽  
Vol 40 (6) ◽  
pp. 1164-1169 ◽  
Author(s):  
Sagar Agarwal ◽  
Yasuo Uchida ◽  
Rajendar K. Mittapalli ◽  
Ramola Sane ◽  
Tetsuya Terasaki ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quantitative Proteomics ◽  
Breast Cancer Resistance Protein ◽  
Cancer Resistance ◽  
Glycoprotein P ◽  
Brain Capillary ◽  
P Glycoprotein ◽  
Capillary Endothelial Cells ◽  
Resistance Protein ◽  
Transporter Expression

scholarly journals P-Glycoprotein and Breast Cancer Resistance Protein Restrict Apical-to-Basolateral Permeability of Human Brain Endothelium to Amyloid-β

2009 ◽  
Vol 29 (6) ◽  
pp. 1079-1083 ◽  
Author(s):  
Leon M Tai ◽  
A Jane Loughlin ◽  
David K Male ◽  
Ignacio A Romero
Keyword(s):  
Breast Cancer ◽  
Human Brain ◽  
Breast Cancer Resistance Protein ◽  
Amyloid Β ◽  
Cancer Resistance ◽  
Glycoprotein P ◽  
P Glycoprotein ◽  
Resistance Protein ◽  
The Brain

The clearance of amyloid beta (Aβ) from the brain represents a novel therapeutic target for Alzheimer's disease. Conflicting data exist regarding the contribution of adenosine triphosphatebinding cassette transporters to the clearance of Aβ through the blood-brain barrier. Therefore, we investigated whether Aβ could be a substrate for P-glycoprotein (P-gp) and/or for breast cancer resistance protein (BCRP) using a human brain endothelial cell line, hCMEC/D3. Inhibition of P-gp and BCRP increased apical-to-basolateral, but not basolateral-to-apical, permeability of hCMEC/D3 cells to 125l Aβ 1–40. Our in vitro data suggest that P-gp and BCRP might act to prevent the blood-borne Aβ 1–40 from entering the brain.

scholarly journals Brain and Testis Accumulation of Regorafenib is Restricted by Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1)

2015 ◽  
Vol 32 (7) ◽  
pp. 2205-2216 ◽  
Author(s):  
Anita Kort ◽  
Selvi Durmus ◽  
Rolf W. Sparidans ◽  
Els Wagenaar ◽  
Jos H. Beijnen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Resistance Protein ◽  
Cancer Resistance ◽  
Glycoprotein P ◽  
P Glycoprotein ◽  
Resistance Protein
Sign in / Sign up

Export Citation Format

Share Document