Inhibition of Heme Oxygenase-1 Partially Reverses the Arsenite-Mediated Decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 Catalytic Activity in Isolated Rat Hepatocytes

2011 ◽  
Vol 40 (3) ◽  
pp. 504-514 ◽  
Author(s):  
Anwar Anwar-Mohamed ◽  
Lars-Oliver Klotz ◽  
Ayman O. S. El-Kadi
Keyword(s):  
Catalytic Activity ◽  
Heme Oxygenase ◽  
Rat Hepatocytes ◽  
Heme Oxygenase 1 ◽  
Isolated Rat Hepatocytes ◽  
Isolated Rat

scholarly journals Stereoselectivity of rat liver glutathione transferase isoenzymes for α-bromoisovaleric acid and α-bromoisovalerylurea enantiomers

1988 ◽  
Vol 252 (1) ◽  
pp. 137-142 ◽  
Author(s):  
J M Te Koppele ◽  
B Coles ◽  
B Ketterer ◽  
G J Mulder
Keyword(s):  
Catalytic Activity ◽  
Rat Liver ◽  
Multigene Family ◽  
Glutathione Transferase ◽  
Rat Hepatocytes ◽  
Isolated Rat Hepatocytes ◽  
Liver Glutathione ◽  
Amide Derivative ◽  
Isolated Rat

The stereoselectivity of purified rat GSH transferases towards alpha-bromoisovaleric acid (BI) and its amide derivative alpha-bromoisovalerylurea (BIU) was investigated. GSH transferase 2-2 was the only enzyme to catalyse the conjugation of BI and was selective for the (S)-enantiomer. The conjugation of (R)- and (S)-BIU was catalysed by the isoenzymes 2-2, 3-3 and 4-4. Transferase 1-1 was less active, and no catalytic activity was observed with transferase 7-7. Isoenzymes 1-1 and 2-2 of the Alpha multigene family preferentially catalysed the conjugation of the (S)-enantiomer of BIU (and BI), whereas isoenzymes 3-3 and 4-4 of the Mu multigene family preferred (R)-BIU. The opposite stereoselectivity of conjugation of BI and BIU previously observed in isolated rat hepatocytes and the summation of activities of enzymes known to be present in hepatocytes on the basis of present data are in accord.

scholarly journals Lysosomal triacylglycerol lipase and lipolysis in isolated rat hepatocytes.

1979 ◽  
Vol 254 (18) ◽  
pp. 8841-8846
Author(s):  
L.J. Debeer ◽  
J. Thomas ◽  
P.J. De Schepper ◽  
G.P. Mannaerts
Keyword(s):  
Rat Hepatocytes ◽  
Isolated Rat Hepatocytes ◽  
Triacylglycerol Lipase ◽  
Isolated Rat
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