scholarly journals p-Anilinoaniline Enhancement of Dioxin-Induced CYP1A1 Transcription and Aryl Hydrocarbon Receptor Occupancy of CYP1A1 Promoter: Role of the Cell Cycle

2012 ◽  
Vol 40 (5) ◽  
pp. 1032-1040 ◽  
Author(s):  
Althea Elliott ◽  
Aby Joiakim ◽  
Patricia A. Mathieu ◽  
Zofia Duniec-Dmuchowski ◽  
Thomas A. Kocarek ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Aryl Hydrocarbon Receptor ◽  
Receptor Occupancy ◽  
Aryl Hydrocarbon

scholarly journals Aryl hydrocarbon receptor (AHR) is a potential tumour suppressor in pituitary adenomas

2017 ◽  
Vol 24 (8) ◽  
pp. 445-457 ◽  
Author(s):  
R Formosa ◽  
J Borg ◽  
J Vassallo
Keyword(s):  
Cell Cycle ◽  
Aryl Hydrocarbon Receptor ◽  
Pituitary Adenomas ◽  
Tumour Suppressor ◽  
Gh3 Cells ◽  
Altered Expression ◽  
Aryl Hydrocarbon ◽  
Cell Cycle Regulator ◽  
Regulator Genes

Pituitary adenomas (PA) represent the largest group of intracranial neoplasms and yet the molecular mechanisms driving this disease remain largely unknown. The aim of this study was to use a high-throughput screening method to identify molecular pathways that may be playing a significant and consistent role in PA. RNA profiling using microarrays on eight local PAs identified the aryl hydrocarbon receptor (AHR) signalling pathway as a key canonical pathway downregulated in all PA types. This was confirmed by real-time PCR in 31 tumours. The AHR has been shown to regulate cell cycle progression in various cell types; however, its role in pituitary tissue has never been investigated. In order to validate the role of AHR in PA behaviour, further functional studies were undertaken. Over-expression of AHR in GH3 cells revealed a tumour suppressor potential independent of exogenous ligand activation by benzo α-pyrene (BαP). Cell cycle analysis and quantitative PCR of cell cycle regulator genes revealed that both unstimulated and BαP-stimulated AHR reduced E2F-driven transcription and altered expression of cell cycle regulator genes, thus increasing the percentage of cells in G0/G1 phase and slowing the proliferation rate of GH3 cells. Co-immunoprecipitation confirmed the interaction between AHR and retinoblastoma (Rb1) protein supporting this as a functional mechanism for the observed reduction. Endogenous Ahr reduction using silencing RNA confirmed the tumour suppressive function of the Ahr. These data support a mechanistic pathway for the putative tumour suppressive role of AHR specifically in PA, possibly through its role as a cell cycle co-regulator, even in the absence of exogenous ligands.

Role of the aryl hydrocarbon receptor in cell cycle regulation

Toxicology ◽  
2002 ◽  
Vol 181-182 ◽  
pp. 171-177 ◽  
Author(s):  
Alvaro Puga ◽  
Jennifer Marlowe ◽  
Sonya Barnes ◽  
Ching-yi Chang ◽  
Andrew Maier ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Aryl Hydrocarbon Receptor ◽  
Cell Cycle Regulation ◽  
Aryl Hydrocarbon ◽  
Cycle Regulation

Role of the Aryl Hydrocarbon Receptor (AhR) in Mediating the Effects of Coffee in the Colon

2021 ◽  
pp. 2100539
Author(s):  
Robert S. Chapkin ◽  
Laurie A. Davidson ◽  
Hyejin Park ◽  
Un‐Ho Jin ◽  
Yang‐Yi Fan ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Aryl Hydrocarbon

Role of the Aryl Hydrocarbon Receptor in the Pathogenesis of Chronic Rhinosinusitis with Nasal Polyps

Inflammation ◽  
2013 ◽  
Vol 37 (2) ◽  
pp. 387-395 ◽  
Author(s):  
Ping Wei ◽  
Guo-hua Hu ◽  
Hou-yong Kang ◽  
Hong-bing Yao ◽  
Wei Kou ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Aryl Hydrocarbon

scholarly journals Author response: Metabolic profiling during malaria reveals the role of the aryl hydrocarbon receptor in regulating kidney injury

2020 ◽  
Author(s):  
Michelle M Lissner ◽  
Katherine Cumnock ◽  
Nicole M Davis ◽  
José G Vilches-Moure ◽  
Priyanka Basak ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Metabolic Profiling ◽  
Kidney Injury ◽  
Author Response ◽  
Aryl Hydrocarbon

scholarly journals Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?

2021 ◽  
Vol 22 (17) ◽  
pp. 9460
Author(s):  
Helmut Segner ◽  
Christyn Bailey ◽  
Carolina Tafalla ◽  
Jun Bo
Keyword(s):  
Immune System ◽  
Aryl Hydrocarbon Receptor ◽  
Disease Susceptibility ◽  
Immune Cell ◽  
Physiological Role ◽  
Immune Gene ◽  
Immune Systems ◽  
Aryl Hydrocarbon ◽  
The Impact

The impact of anthropogenic contaminants on the immune system of fishes is an issue of growing concern. An important xenobiotic receptor that mediates effects of chemicals, such as halogenated aromatic hydrocarbons (HAHs) and polyaromatic hydrocarbons (PAHs), is the aryl hydrocarbon receptor (AhR). Fish toxicological research has focused on the role of this receptor in xenobiotic biotransformation as well as in causing developmental, cardiac, and reproductive toxicity. However, biomedical research has unraveled an important physiological role of the AhR in the immune system, what suggests that this receptor could be involved in immunotoxic effects of environmental contaminants. The aims of the present review are to critically discuss the available knowledge on (i) the expression and possible function of the AhR in the immune systems of teleost fishes; and (ii) the impact of AhR-activating xenobiotics on the immune systems of fish at the levels of immune gene expression, immune cell proliferation and immune cell function, immune pathology, and resistance to infectious disease. The existing information indicates that the AhR is expressed in the fish immune system, but currently, we have little understanding of its physiological role. Exposure to AhR-activating contaminants results in the modulation of numerous immune structural and functional parameters of fish. Despite the diversity of fish species studied and the experimental conditions investigated, the published findings rather uniformly point to immunosuppressive actions of xenobiotic AhR ligands in fish. These effects are often associated with increased disease susceptibility. The fact that fish populations from HAH- and PAH-contaminated environments suffer immune disturbances and elevated disease susceptibility highlights that the immunotoxic effects of AhR-activating xenobiotics bear environmental relevance.

Sign in / Sign up

Export Citation Format

Share Document