scholarly journals Monoclonal Antibody-Glial-Derived Neurotrophic Factor Fusion Protein Penetrates the Blood-Brain Barrier in the Mouse

2010 ◽  
Vol 38 (4) ◽  
pp. 566-572 ◽  
Author(s):  
Qing-Hui Zhou ◽  
Ruben J. Boado ◽  
Jeff Zhiqiang Lu ◽  
Eric Ka-Wai Hui ◽  
William M. Pardridge
Keyword(s):  
Monoclonal Antibody ◽  
Fusion Protein ◽  
Blood Brain Barrier ◽  
Neurotrophic Factor ◽  
Brain Barrier ◽  
Blood Brain ◽  
Glial Derived Neurotrophic Factor

scholarly journals Dual Roles of Astrocyte-Derived Factors in Regulation of Blood-Brain Barrier Function after Brain Damage

2019 ◽  
Vol 20 (3) ◽  
pp. 571 ◽  
Author(s):  
Shotaro Michinaga ◽  
Yutaka Koyama
Keyword(s):  
Brain Damage ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Secondary Damage ◽  
The Central Nervous System ◽  
Bbb Permeability ◽  
Novel Therapeutic Strategies ◽  
Glial Derived Neurotrophic Factor ◽  
Endothelial Growth Factors

The blood-brain barrier (BBB) is a major functional barrier in the central nervous system (CNS), and inhibits the extravasation of intravascular contents and transports various essential nutrients between the blood and the brain. After brain damage by traumatic brain injury, cerebral ischemia and several other CNS disorders, the functions of the BBB are disrupted, resulting in severe secondary damage including brain edema and inflammatory injury. Therefore, BBB protection and recovery are considered novel therapeutic strategies for reducing brain damage. Emerging evidence suggests key roles of astrocyte-derived factors in BBB disruption and recovery after brain damage. The astrocyte-derived vascular permeability factors include vascular endothelial growth factors, matrix metalloproteinases, nitric oxide, glutamate and endothelin-1, which enhance BBB permeability leading to BBB disruption. By contrast, the astrocyte-derived protective factors include angiopoietin-1, sonic hedgehog, glial-derived neurotrophic factor, retinoic acid and insulin-like growth factor-1 and apolipoprotein E which attenuate BBB permeability resulting in recovery of BBB function. In this review, the roles of these astrocyte-derived factors in BBB function are summarized, and their significance as therapeutic targets for BBB protection and recovery after brain damage are discussed.

scholarly journals Temporary disruption of the rat blood–brain barrier with a monoclonal antibody: A novel method for dynamic manganese-enhanced MRI

NeuroImage ◽  
2010 ◽  
Vol 50 (1) ◽  
pp. 7-14 ◽  
Author(s):  
Hanbing Lu ◽  
Steven Demny ◽  
Yantao Zuo ◽  
William Rea ◽  
Leiming Wang ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Rat Blood ◽  
Blood Brain ◽  
Enhanced Mri ◽  
Novel Method ◽  
Manganese Enhanced Mri

Osmotic Blood-Brain Barrier Modification: Monoclonal Antibody, Albumin, and Methotrexate Delivery to Cerebrospinal Fluid and Brain

Neurosurgery ◽  
1985 ◽  
Vol 17 (3) ◽  
pp. 419-423 ◽  
Author(s):  
Edward A. Neuwelt ◽  
Peggy A. Barnett ◽  
Christopher I. McCormick ◽  
Eugene P. Frenkel ◽  
John D. Minna
Keyword(s):  
Monoclonal Antibody ◽  
Cerebrospinal Fluid ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain
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