Budesonide and Ciclesonide: Effect of Tissue Binding on Pulmonary Receptor Binding

Kai Wu; Anders L. Blomgren; Kjell Ekholm; Benjamin Weber; Staffan Edsbaecker; Günther Hochhaus

doi:10.1124/dmd.108.026039

Budesonide and Ciclesonide: Effect of Tissue Binding on Pulmonary Receptor Binding

Drug Metabolism and Disposition ◽

10.1124/dmd.108.026039 ◽

2009 ◽

Vol 37 (7) ◽

pp. 1421-1426 ◽

Cited By ~ 14

Author(s):

Kai Wu ◽

Anders L. Blomgren ◽

Kjell Ekholm ◽

Benjamin Weber ◽

Staffan Edsbaecker ◽

...

Keyword(s):

Receptor Binding ◽

Tissue Binding ◽

Pulmonary Receptor

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An extended pharmacokinetic/pharmacodynamic model describing quantitatively the influence of plasma protein binding, tissue binding, and receptor binding on the potency and time course of action of drugs

Journal of Pharmacokinetics and Biopharmaceutics ◽

10.1007/bf02353510 ◽

1996 ◽

Vol 24 (1) ◽

pp. 45-77 ◽

Cited By ~ 19

Author(s):

Johannes H. Proost ◽

J. Mark K. H. Wierda ◽

Dirk K. F. Meijer

Keyword(s):

Protein Binding ◽

Plasma Protein Binding ◽

Receptor Binding ◽

Plasma Protein ◽

Time Course ◽

Pharmacodynamic Model ◽

Tissue Binding ◽

Course Of Action

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Effect of cerebral hypoxia on NMDA receptor binding characteristics after treatment with 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) in newborn piglets

Brain Research ◽

10.1016/s0006-8993(96)00232-6 ◽

1996 ◽

Vol 729 (1) ◽

pp. 66-74

Author(s):

K Fritz

Keyword(s):

Nmda Receptor ◽

Receptor Binding ◽

Phosphonic Acid ◽

Cerebral Hypoxia ◽

Binding Characteristics ◽

Newborn Piglets ◽

Nmda Receptor Binding

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Calcitonin Gene-Related Peptide (CGRP) receptor binding and localization in nonpregnant and pregnant rat uterus and regulation by sex steroid hormones

Journal of the Society for Gynecologic Investigation ◽

10.1016/s1071-5576(97)86210-7 ◽

1998 ◽

Vol 5 (1) ◽

pp. 73A-73A ◽

Cited By ~ 1

Author(s):

C YALLAMPALLI ◽

P GANGULA ◽

Y DONG ◽

L FANG ◽

S WIMALAWANSA

Keyword(s):

Steroid Hormones ◽

Receptor Binding ◽

Calcitonin Gene Related Peptide ◽

Sex Steroid Hormones ◽

Sex Steroid ◽

Cgrp Receptor ◽

Rat Uterus ◽

Pregnant Rat ◽

Related Peptide ◽

Calcitonin Gene

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Effect of amphetamine on dopamine D2 receptor binding in the primate brain with the agonist ligand [11C]MNPA

Journal of Cerebral Blood Flow & Metabolism ◽

10.1038/sj.jcbfm.9591524.0646 ◽

2005 ◽

Vol 25 (1_suppl) ◽

pp. S646-S646

Author(s):

Nicholas Seneca ◽

Sjoerd Finnema ◽

Masanori Ichise ◽

Balazs Gulyas ◽

Håkan Wikstrom ◽

...

Keyword(s):

Receptor Binding ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

Dopamine D2 ◽

Primate Brain

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Antiproliferative and antiviral effects of mutated IFN-alpha with increased IFN receptor binding affinity

Zeitschrift für Gastroenterologie ◽

10.1055/s-0030-1269699 ◽

2011 ◽

Vol 49 (01) ◽

Author(s):

MF Sprinzl ◽

L Bührer ◽

D Strand ◽

G Schreiber ◽

PR Galle ◽

...

Keyword(s):

Binding Affinity ◽

Receptor Binding ◽

Receptor Binding Affinity ◽

Ifn Alpha ◽

Antiviral Effects

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Decreased Dopamine D2/D3-Receptor Binding in the Temporal Lobe and the Bilateral Basal Ganglia in patients with Temporal Lobe Epilepsy

Klinische Neurophysiologie ◽

10.1055/s-0032-1301572 ◽

2012 ◽

Vol 43 (01) ◽

Author(s):

VE Bernedo Paredes ◽

H Schwartz ◽

M Gartenschläger ◽

HG Buchholz ◽

...

Keyword(s):

Basal Ganglia ◽

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Receptor Binding ◽

D3 Receptor ◽

Dopamine D2

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Vergleich von Blutfluß und Benzodiazepin-Rezeptorverteilung bei fokaler Epilepsie: Vorläufige Ergebnisse einer SPECT-Studie

Nuklearmedizin ◽

10.1055/s-0038-1629489 ◽

1989 ◽

Vol 28 (05) ◽

pp. 181-186

Author(s):

A. Ludolph ◽

O. Schober ◽

G. Lottes ◽

I. Böttger ◽

H.-F. Beer ◽

...

Keyword(s):

Human Brain ◽

Receptor Binding ◽

Brain Area ◽

Brain Perfusion ◽

Partial Epilepsy ◽

Cerebral Lesion ◽

Receptor Ligand ◽

Receptor Mapping ◽

Hmpao Spect ◽

99Mtc Hmpao

99mTc-HMPAO-SPECT and SPECT with the 123I-labelled benzodiazepine (Bz) receptor ligand Ro 16-0154 were performed in 10 patients suffering from partial epilepsy, without cerebral lesion in MRT or CT. 2 h p.i. of Ro 16-0154 the distribution of activity correlated with the known distribution of Bz- receptors in the human brain. Perfusion and receptor-binding were found decreased in 7 patients of each study in the suspicious brain-area. 123l-labelled Ro 16-0154 is suitable for Bz-receptor mapping by SPECT. The decrease of Bz-receptor binding in epileptic foci, as described in PET-studies, was also detected by SPECT in 7 of 10 patients.

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