CYP3A4-Mediated Ester Cleavage as the Major Metabolic Pathway of the Oral Taxane 3′-tert-Butyl-3′-N-tert-butyloxycarbonyl-4-deacetyl-3′-dephenyl-3′-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel (BMS-275183)

2009 ◽  
Vol 37 (4) ◽  
pp. 710-718 ◽  
Author(s):  
Donglu Zhang ◽  
Van T. Ly ◽  
Michael Lago ◽  
Yuan Tian ◽  
Jinping Gan ◽  
...  
Keyword(s):  
Metabolic Pathway ◽  
Tert Butyl ◽  
Major Metabolic Pathway

scholarly journals Effect of Acute and Chronic Exposure to High Altitude on the Aerobic and Anaerobic Metabolism in Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Qian Ni ◽  
Feng Qi Wan ◽  
Yu Hong Jing ◽  
Xiang Yu Dong ◽  
You Cheng Zhang
Keyword(s):  
High Altitude ◽  
Metabolic Pathway ◽  
Chronic Exposure ◽  
Anaerobic Metabolism ◽  
Hepatic Expression ◽  
Lactate Levels ◽  
Acute And Chronic Exposure ◽  
Stressful Environments ◽  
Major Metabolic Pathway ◽  
Aerobic And Anaerobic

In this study, we aimed to investigate the effect of acute and chronic exposure to HA on the aerobic and anaerobic metabolism in liver by determining the hepatic levels of ICDH and ATP. Lactate levels in liver and blood were also examined. Rats were exposed to an altitude of 4,300 m for 30 days, and those without HA exposure were used as controls. We observed an increased expression of liver ICDH following acute exposure (days 1, 3, and 7), whereas the liver ATP concentration was reduced on day 1. No changes in the hepatic expression of ICDH and ATP were found in rats chronically exposed to HA. Lactate concentrations of liver and blood did not show any significant changes following HA exposure. Thus, aerobic metabolism may be the major metabolic pathway in response to HA hypoxia in order to acclimatize themselves to the stressful environments.

scholarly journals Biotransformation of 8:2 fluorotelomer alcohol by recombinant human cytochrome P450s, human liver microsomes and human liver cytosol

2016 ◽  
Vol 18 (5) ◽  
pp. 538-546 ◽  
Author(s):  
Zhong-Min Li ◽  
Liang-Hong Guo ◽  
Xiao-Min Ren
Keyword(s):  
Phase I ◽  
Phase Ii ◽  
Metabolic Pathway ◽  
Human Liver ◽  
Liver Microsomes ◽  
Cytochrome P450s ◽  
Phase Ii Metabolism ◽  
Liver Cytosol ◽  
Human Cytochrome ◽  
Major Metabolic Pathway

CYP2C19 catalyzes the phase I metabolism of 8:2 FTOH in humans, while phase II metabolism is the major metabolic pathway.

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