Metabolism, Pharmacokinetics, and Excretion of a Cholesteryl Ester Transfer Protein Inhibitor, Torcetrapib, in Rats, Monkeys, and Mice: Characterization of Unusual and Novel Metabolites by High-Resolution Liquid Chromatography-Tandem Mass Spectrometry and 1H Nuclear Magnetic Resonance

Chandra Prakash; Weichao Chen; Michelle Rossulek; Kim Johnson; Chenghong Zhang; Thomas O'Connell; Michael Potchoiba; Deepak Dalvie

doi:10.1124/dmd.108.022277

Metabolism, Pharmacokinetics, and Excretion of a Cholesteryl Ester Transfer Protein Inhibitor, Torcetrapib, in Rats, Monkeys, and Mice: Characterization of Unusual and Novel Metabolites by High-Resolution Liquid Chromatography-Tandem Mass Spectrometry and 1H Nuclear Magnetic Resonance

Drug Metabolism and Disposition ◽

10.1124/dmd.108.022277 ◽

2008 ◽

Vol 36 (10) ◽

pp. 2064-2079 ◽

Cited By ~ 32

Author(s):

Chandra Prakash ◽

Weichao Chen ◽

Michelle Rossulek ◽

Kim Johnson ◽

Chenghong Zhang ◽

...

Keyword(s):

Mass Spectrometry ◽

Nuclear Magnetic Resonance ◽

Liquid Chromatography ◽

Tandem Mass ◽

Protein Inhibitor ◽

Transfer Protein ◽

Chromatography Tandem Mass Spectrometry ◽

1H Nuclear Magnetic Resonance ◽

Liquid Chromatography Tandem Mass

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CYP2C8- and CYP3A-Mediated C-Demethylation of (3-{[(4-tert-Butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic Acid (CP-533,536), an EP2 Receptor-Selective Prostaglandin E2 Agonist: Characterization of Metabolites by High-Resolution Liquid Chromatography-Tandem Mass Spectrometry and Liquid Chromatography/Mass Spectrometry-Nuclear Magnetic Resonance

Drug Metabolism and Disposition ◽

10.1124/dmd.108.022897 ◽

2008 ◽

Vol 36 (10) ◽

pp. 2093-2103 ◽

Cited By ~ 14

Author(s):

Chandra Prakash ◽

Weiwei Wang ◽

Thomas O'Connell ◽

Kim A. Johnson

Keyword(s):

Mass Spectrometry ◽

Nuclear Magnetic Resonance ◽

Acetic Acid ◽

Liquid Chromatography ◽

Tandem Mass ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass ◽

Ep2 Receptor

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Proteome characterization of human pancreatic cyst fluid from intraductal papillary mucinous neoplasm by liquid chromatography/tandem mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.7959 ◽

2017 ◽

Vol 31 (20) ◽

pp. 1761-1772 ◽

Cited By ~ 7

Author(s):

Joonho Park ◽

Dohyun Han ◽

Misol Do ◽

Jongmin Woo ◽

Joseph I. Wang ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Pancreatic Cyst ◽

Tandem Mass ◽

Mucinous Neoplasm ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass ◽

Pancreatic Cyst Fluid

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Identification and Characterization of Terpenoid Lactones and Flavonoids from Ethanolic Extract ofAndrographis Paniculata(Burm.f.) Nees Using Liquid Chromatography/Tandem Mass Spectrometry

Separation Science Plus ◽

10.1002/sscp.201800106 ◽

2018 ◽

Vol 1 (12) ◽

pp. 762-770 ◽

Cited By ~ 2

Author(s):

Sunil Kumar ◽

Awantika Singh ◽

Vikas Bajpai ◽

Kulwant R. Sharma ◽

Brijesh Kumar

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Ethanolic Extract ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass ◽

Identification And Characterization

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Characterization of tanshinones with quinone reductase induction activity from Radix Salvia miltiorrhiza by liquid chromatography/tandem mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.4195 ◽

2009 ◽

Vol 23 (18) ◽

pp. 2857-2866 ◽

Cited By ~ 22

Author(s):

Zhongjun Ma ◽

Min Zhang ◽

Zhihang Song

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Salvia Miltiorrhiza ◽

Quinone Reductase ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass ◽

Radix Salvia Miltiorrhiza

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Liquid chromatography–tandem mass spectrometry characterization of ergocristam degradation products

Journal of Chromatography B ◽

10.1016/j.jchromb.2008.08.004 ◽

2008 ◽

Vol 873 (2) ◽

pp. 165-172 ◽

Cited By ~ 7

Author(s):

Jana Olšovská ◽

Miroslav Šulc ◽

Petr Novák ◽

Sylvie Pažoutová ◽

Miroslav Flieger

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Degradation Products ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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Identification and characterization of reaction products of 5-hydroxytryptamine with methylglyoxal and glyoxal by liquid chromatography/tandem mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.8195 ◽

2018 ◽

Vol 32 (17) ◽

pp. 1529-1539 ◽

Cited By ~ 2

Author(s):

L. Sai Sachin ◽

R. Nagarjuna Chary ◽

P. Pavankumar ◽

S. Prabhakar

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Tandem Mass ◽

Reaction Products ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass ◽

Identification And Characterization

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Fast and Quantitative Phospholipidomic Analysis of SH-SY5Y Neuroblastoma Cell Cultures Using Liquid Chromatography–Tandem Mass Spectrometry and 31P Nuclear Magnetic Resonance

ACS Omega ◽

10.1021/acsomega.9b03463 ◽

2019 ◽

Vol 4 (25) ◽

pp. 21596-21603 ◽

Cited By ~ 1

Author(s):

Martin Jakubec ◽

Espen Bariås ◽

Fedor Kryuchkov ◽

Linda Veka Hjørnevik ◽

Øyvind Halskau

Keyword(s):

Mass Spectrometry ◽

Nuclear Magnetic Resonance ◽

Liquid Chromatography ◽

Magnetic Resonance ◽

Tandem Mass Spectrometry ◽

Cell Cultures ◽

Neuroblastoma Cell ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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Characterization of ecdysteroids in Drosophila melanogaster by enzyme immunoassay and nano-liquid chromatography–tandem mass spectrometry

Journal of Chromatography B ◽

10.1016/j.jchromb.2010.02.018 ◽

2010 ◽

Vol 878 (13-14) ◽

pp. 925-932 ◽

Cited By ~ 19

Author(s):

Catherine Blais ◽

Thierry Blasco ◽

Annick Maria ◽

Chantal Dauphin-Villemant ◽

René Lafont

Keyword(s):

Mass Spectrometry ◽

Drosophila Melanogaster ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Enzyme Immunoassay ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass ◽

Nano Liquid Chromatography

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Characterization of carboxylic acids in atmospheric aerosols using hydrophilic interaction liquid chromatography tandem mass spectrometry

Journal of Chromatography A ◽

10.1016/j.chroma.2011.05.020 ◽

2011 ◽

Vol 1218 (28) ◽

pp. 4417-4425 ◽

Cited By ~ 35

Author(s):

Zoran Kitanovski ◽

Irena Grgić ◽

Marjan Veber

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Carboxylic Acids ◽

Atmospheric Aerosols ◽

Tandem Mass ◽

Hydrophilic Interaction ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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Identification and partial characterization of C-glycosylflavone markers in Asian plant dyes using liquid chromatography–tandem mass spectrometry

Journal of Chromatography A ◽

10.1016/j.chroma.2011.08.048 ◽

2011 ◽

Vol 1218 (41) ◽

pp. 7325-7330 ◽

Cited By ~ 18

Author(s):

Chika Mouri ◽

Richard Laursen

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Partial Characterization ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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