Markers of Electrophilic Stress Caused by Chemically Reactive Metabolites in Human Hepatocytes

2008 ◽  
Vol 36 (5) ◽  
pp. 816-823 ◽  
Author(s):  
Hideo Takakusa ◽  
Hiroshi Masumoto ◽  
Ayako Mitsuru ◽  
Osamu Okazaki ◽  
Kenichi Sudo
Keyword(s):  
Human Hepatocytes ◽  
Reactive Metabolites ◽  
Electrophilic Stress

Bioactivation of diclofenac in human hepatocytes and the proposed human hepatic proteins modified by reactive metabolites

Xenobiotica ◽  
2020 ◽  
Vol 50 (8) ◽  
pp. 919-928 ◽  
Author(s):  
Kazuko Inoue ◽  
Hitoshi Mizuo ◽  
Tomomi Ishida ◽  
Takafumi Komori ◽  
Kazutomi Kusano
Keyword(s):  
Human Hepatocytes ◽  
Reactive Metabolites ◽  
Hepatic Proteins

Formation of GSH-trapped reactive metabolites in human liver microsomes, S9 fraction, HepaRG-cells, and human hepatocytes

2015 ◽  
Vol 115 ◽  
pp. 345-351 ◽  
Author(s):  
Toni Lassila ◽  
Timo Rousu ◽  
Sampo Mattila ◽  
Christophe Chesné ◽  
Olavi Pelkonen ◽  
...  
Keyword(s):  
Human Liver ◽  
Liver Microsomes ◽  
Human Hepatocytes ◽  
Human Liver Microsomes ◽  
Reactive Metabolites ◽  
Heparg Cells ◽  
S9 Fraction

scholarly journals Identification of Protein Targets of Reactive Metabolites of Tienilic Acid in Human Hepatocytes

2012 ◽  
Vol 25 (5) ◽  
pp. 1145-1154 ◽  
Author(s):  
Yakov M. Koen ◽  
Diganta Sarma ◽  
Todd D. Williams ◽  
Nadezhda A. Galeva ◽  
R. Scott Obach ◽  
...  
Keyword(s):  
Human Hepatocytes ◽  
Reactive Metabolites ◽  
Tienilic Acid ◽  
Protein Targets

Evaluation of Flutamide Genotoxicity in Rats and in Primary Human Hepatocytes

2000 ◽  
Vol 86 (3) ◽  
pp. 129-134 ◽  
Author(s):  
Antonietta MartelliNote ◽  
Giulia Brambilla Campart ◽  
Roberto Carrozzino ◽  
Marco Ghia ◽  
Francesca Mattioli ◽  
...  
Keyword(s):  
Human Hepatocytes ◽  
Primary Human Hepatocytes

Continuous lipid treatment of primary human hepatocytes leads to an elevation of oxidative stress

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
T Schulz ◽  
V Kegel ◽  
B Burkhardt ◽  
D Seehofer ◽  
M Glanemann ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Hepatocytes ◽  
Primary Human Hepatocytes
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