Characterization of Ebastine, Hydroxyebastine, and Carebastine Metabolism by Human Liver Microsomes and Expressed Cytochrome P450 Enzymes: Major Roles for CYP2J2 and CYP3A

2006 ◽  
Vol 34 (11) ◽  
pp. 1793-1797 ◽  
Author(s):  
Kwang-Hyeon Liu ◽  
Mi-Gyung Kim ◽  
Dong-Jun Lee ◽  
Yune-Jung Yoon ◽  
Min-Jung Kim ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cytochrome P450 Enzymes

In vitrometabolism of magnolin and characterization of cytochrome P450 enzymes responsible for its metabolism in human liver microsomes

Xenobiotica ◽  
2011 ◽  
Vol 41 (5) ◽  
pp. 358-371 ◽  
Author(s):  
Dong Kyun Kim ◽  
Kwang-Hyeon Liu ◽  
Ji Hyun Jeong ◽  
Hye Young Ji ◽  
Sei-Ryang Oh ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cytochrome P450 Enzymes

scholarly journals Characterization of O-demethylations and Aromatic Hydroxylations Mediated by Cytochromes P450 in the Metabolism of Flavonoid Aglycons

2019 ◽  
Vol 92 (1) ◽  
pp. 115-123 ◽  
Author(s):  
Goran Benković ◽  
Hrvoje Rimac ◽  
Željan Maleš ◽  
Siniša Tomić ◽  
Zoran Lončar ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Cytochromes P450 ◽  
Liver Microsomes ◽  
Cytochrome P450 Enzymes ◽  
Uv Detector ◽  
Aromatic Hydroxylation ◽  
Metabolism Of Xenobiotics ◽  
Kinetics Of

One of the most important groups of metabolic enzymes is cytochrome P450 superfamily. These enzymes are important in terms of the catalytic diversity and the large number of xenobiotics that are detoxified or activated by converting to reactive metabolites. Flavonoids are xenobiotics to which humans are exposed through diet. Data on their oxidative metabolism mediated by cytochromes P450 are limited. The aim of this study was to determine the enzymatic kinetics of O-demethylation and aromatic hydroxylation of flavonoid aglycons on recombinant cytochrome P450 enzymes and human liver microsomes systems. The study was performed on ten flavonoids, namely 3,7-dihydroxyflavone, 7-hydroxyflavone, acacetin, apigenin, flavone, galangin, kaempferol, naringenin, sakuranetin, and tangeretin using liquid chromatography coupled with mass spectrometry and UV detector. Most relevant enzyme involved in metabolism of flavonoid aglycons is CYP1A2, and its catalytic effectiveness ranges from 0.5 to 2.9 × 106 M–1 min–1. Having in mind high expression and involvement of CYP1A2 in metabolism of xenobiotics including drugs, and its intraindividual differences in expression and activity, potential of drug-flavonoid competitive interactions/inhibitions should be considered when consuming dietary supplement and foods rich in flavonoids.

Metabolism of (-)-cis- and (-)-trans-rose oxide by cytochrome P450 enzymes in human liver microsomes

2015 ◽  
Vol 36 (9) ◽  
pp. 565-574 ◽  
Author(s):  
Hiroshi Nakahashi ◽  
Yuuki Yamamura ◽  
Atsushi Usami ◽  
Pramoch Rangsunvigit ◽  
Pomthong Malakul ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cytochrome P450 Enzymes ◽  
Cis And Trans

Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes

Life Sciences ◽  
2011 ◽  
Vol 89 (5-6) ◽  
pp. 165-170 ◽  
Author(s):  
Rongrong Jiang ◽  
Satoshi Yamaori ◽  
Shuso Takeda ◽  
Ikuo Yamamoto ◽  
Kazuhito Watanabe
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cytochrome P450 Enzymes
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