Hydrolysis of Angiotensin II Receptor Blocker Prodrug Olmesartan Medoxomil by Human Serum Albumin and Identification of Its Catalytic Active Sites

2005 ◽  
Author(s):  
S.-F. Ma
Keyword(s):  
Angiotensin Ii ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Active Sites ◽  
Olmesartan Medoxomil ◽  
Angiotensin Ii Receptor Blocker ◽  
Angiotensin Ii Receptor ◽  
Catalytic Active Sites ◽  
Hydrolysis Of

Synthesis of conjugates of 1-(carboxymethyl)cytosine and 1-(5-O-carboxymethyl-β-D-arabinofuranosyl)cytosine with proteins

1979 ◽  
Vol 44 (10) ◽  
pp. 3023-3032 ◽  
Author(s):  
Helmut Pischel ◽  
Antonín Holý ◽  
Günther Wagner
Keyword(s):  
Human Serum Albumin ◽  
Acetic Anhydride ◽  
Serum Albumin ◽  
Human Serum ◽  
Activated Esters ◽  
Hydrolysis Of

1-(Carboxymethyl)cytosine (Ia), 1-(5-O-carboxymethyl-β-D-arabinofuranosyl)cytosine (IIa) and 5'-O-carboxylmethylcytidine (IIIa) were transformed by treatment with acetic anhydride and 4-dimethylaminopyridine to the peracetyl derivatives Ib-IIIb. These products reacted with p-nitrophenol in the presence of N, N'-dicyclohexylcarbodiimide to give the activated esters Ic-IIIc which on reaction with ammonia, dimethylamine or 2-aminoethanol afforded the corresponding carboxamides Id-IIId, IIe,f. Reactions of Ic and IIc with human serum albumin and bovine γ-globulin at pH 9.2, followed by hydrolysis of the N- or O-acetyl groups at pH 9.5, gave 50% up to 64% yields of the respective conjugates Ig, IIg and Ih, IIh.

scholarly journals The Effect of Ethanol on the Hydrolysis of Ester-Type Drugs by Human Serum Albumin

2018 ◽  
Vol 41 (2) ◽  
pp. 277-280 ◽  
Author(s):  
Akitoshi Tatsumi ◽  
Sachiyo Inoue ◽  
Tsuneo Hamaguchi ◽  
Seigo Iwakawa
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Hydrolysis Of

scholarly journals 4-Hydroxycoumarin Derivative:N-(diphenylmethyl)-2-[(2-oxo-2H-chromen-4-yl)oxy]acetamide Interaction with Human Serum Albumin

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Shanmugavel Chinnathambi ◽  
Subramani Karthikeyan ◽  
Mangaiyarkarsi Rajendiran ◽  
Kanniyappan Udayakumar ◽  
Arunkumar Manoharan ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Active Sites ◽  
Entropy Change ◽  
Protein Molecule ◽  
Coumarin Derivative ◽  
Biologically Active ◽  
Computational Technique ◽  
Distribution Analysis

In this study, the interaction between the coumarin derivative:N-(diphenylmethyl)-2-[(2-oxo-2H-chromen-4-yl)oxy]acetamide, biologically active drug, and human serum albumin (HSA) was investigated by using various optical spectroscopy techniques along with the computational technique. The results of steady-state fluorescence spectroscopy show that the static quenching occurred while increasing the coumarin drug concentration into HSA. Also, the binding constant (K) and thermodynamical parameters of enthalpy change (ΔH°), entropy change (ΔS°), and Gibbs free energy change (ΔG°) were calculated at different temperatures (293 K, 298 K, and 303 K). The results are in good agreement with those of molecular docking studies, and also, the docking study was carried out to understand the hydrogen bonding and hydrophobic interaction between human serum albumin and coumarin derivative. In addition to the docking, charge distribution analysis was done to understand the internal stability of coumarin derivative active sites of human serum albumin. Further time-resolved emission spectroscopy (TRES) studies were carried out between free HSA and HSA-coumarin complex, and the result confirms the presence of the drug in the protein molecule without cytotoxicity.

scholarly journals Hydrolysis of chemically distinct sites of human serum albumin by polyoxometalate: A hybrid QM/MM (ONIOM) study

2018 ◽  
Vol 40 (1) ◽  
pp. 51-61 ◽  
Author(s):  
Vindi M. Jayasinghe-Arachchige ◽  
Qiaoyu Hu ◽  
Gaurav Sharma ◽  
Thomas J. Paul ◽  
Marcus Lundberg ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Hydrolysis Of

Binding and Hydrolysis of Soman by Human Serum Albumin

2008 ◽  
Vol 21 (2) ◽  
pp. 421-431 ◽  
Author(s):  
Bin Li ◽  
Florian Nachon ◽  
Marie-Thérèse Froment ◽  
Laurent Verdier ◽  
Jean-Claude Debouzy ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Hydrolysis Of
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