BIMOLECULAR FLUORESCENCE COMPLEMENTATION ANALYSIS OF CYTOCHROME P450 2C2, 2E1, AND NADPH-CYTOCHROME P450 REDUCTASE MOLECULAR INTERACTIONS IN LIVING CELLS

Cengiz Ozalp; Elzbieta Szczesna-Skorupa; Byron Kemper

doi:10.1124/dmd.105.005538

BIMOLECULAR FLUORESCENCE COMPLEMENTATION ANALYSIS OF CYTOCHROME P450 2C2, 2E1, AND NADPH-CYTOCHROME P450 REDUCTASE MOLECULAR INTERACTIONS IN LIVING CELLS

Drug Metabolism and Disposition ◽

10.1124/dmd.105.005538 ◽

2005 ◽

Vol 33 (9) ◽

pp. 1382-1390 ◽

Cited By ~ 44

Author(s):

Cengiz Ozalp ◽

Elzbieta Szczesna-Skorupa ◽

Byron Kemper

Keyword(s):

Cytochrome P450 ◽

Molecular Interactions ◽

Living Cells ◽

Bimolecular Fluorescence Complementation ◽

Complementation Analysis ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Nadph Cytochrome P450 Reductase ◽

Fluorescence Complementation

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Probing the role of lysines and arginines in the catalytic function of cytochrome P450d by site-directed mutagenesis. Interaction with NADPH-cytochrome P450 reductase

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)67801-4 ◽

1991 ◽

Vol 266 (6) ◽

pp. 3372-3375

Author(s):

T Shimizu ◽

T Tateishi ◽

M Hatano ◽

Y Fujii-Kuriyama

Keyword(s):

Cytochrome P450 ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Catalytic Function ◽

Nadph Cytochrome P450 Reductase

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The cytochrome P450 2B4-NADPH cytochrome P450 reductase electron transfer complex is not formed by charge-pairing.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)42093-5 ◽

1992 ◽

Vol 267 (21) ◽

pp. 14669-14676

Author(s):

A.I. Voznesensky ◽

J.B. Schenkman

Keyword(s):

Electron Transfer ◽

Cytochrome P450 ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Cytochrome P450 2B4 ◽

Nadph Cytochrome P450 Reductase ◽

Electron Transfer Complex

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Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase. Implications for increasing the activity against sensitive and multidrug-resistant leukaemia HL60 cells

Anti-Cancer Drugs ◽

10.1097/cad.0b013e32834fcf4f ◽

2012 ◽

Vol 23 (4) ◽

pp. 393-405 ◽

Cited By ~ 5

Author(s):

Dorota Kostrzewa-Nowak ◽

Bohdan Bieg ◽

Mark J.I. Paine ◽

C. Roland Wolf ◽

Jolanta Tarasiuk

Keyword(s):

Cytochrome P450 ◽

Multidrug Resistant ◽

Structural Factors ◽

Cytochrome P450 Reductase ◽

Hl60 Cells ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Anthraquinone Derivatives ◽

Nadph Cytochrome P450 Reductase

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Organization of NADPH-Cytochrome P450 Reductase and CYP1A2 in the Endoplasmic Reticulum—Microdomain Localization Affects Monooxygenase Function

Molecular Pharmacology ◽

10.1124/mol.110.068817 ◽

2010 ◽

Vol 79 (3) ◽

pp. 549-557 ◽

Cited By ~ 24

Author(s):

Lauren Brignac-Huber ◽

James R. Reed ◽

Wayne L. Backes

Keyword(s):

Endoplasmic Reticulum ◽

Cytochrome P450 ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Nadph Cytochrome P450 Reductase

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Role of the prosthetic groups of NADPH-cytochrome P450 reductase in 3-hydroxyanthranilamide-catalyzed, NADPH-dependent superoxide anion production

Redox Report ◽

10.1080/13510002.1996.11747070 ◽

1996 ◽

Vol 2 (5) ◽

pp. 339-344

Author(s):

Y. Ohta ◽

R. Shinohara ◽

I. Ishiguro

Keyword(s):

Cytochrome P450 ◽

Superoxide Anion ◽

Cytochrome P450 Reductase ◽

Superoxide Anion Production ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Anion Production ◽

Nadph Cytochrome P450 Reductase ◽

Prosthetic Groups

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Reduction of cytochrome b5 by NADPH–cytochrome P450 reductase

Archives of Biochemistry and Biophysics ◽

10.1016/j.abb.2005.06.019 ◽

2005 ◽

Vol 440 (2) ◽

pp. 204-211 ◽

Cited By ~ 56

Author(s):

F. Peter Guengerich

Keyword(s):

Cytochrome P450 ◽

Cytochrome B5 ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Nadph Cytochrome P450 Reductase

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Altered heme catabolism by heme oxygenase-1 caused by mutations in human NADPH cytochrome P450 reductase

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2010.08.072 ◽

2010 ◽

Vol 400 (3) ◽

pp. 374-378 ◽

Cited By ~ 26

Author(s):

Amit V. Pandey ◽

Christa E. Flück ◽

Primus E. Mullis

Keyword(s):

Cytochrome P450 ◽

Heme Oxygenase ◽

Heme Oxygenase 1 ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Nadph Cytochrome P450 Reductase

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Membrane Topology of NADPH–Cytochrome P450 Reductase on the Endoplasmic Reticulum

Archives of Biochemistry and Biophysics ◽

10.1006/abbi.1997.0553 ◽

1998 ◽

Vol 351 (2) ◽

pp. 175-179 ◽

Cited By ~ 22

Author(s):

Yuichiro Kida ◽

Satoru Ohgiya ◽

Katsuyoshi Mihara ◽

Masao Sakaguchi

Keyword(s):

Endoplasmic Reticulum ◽

Cytochrome P450 ◽

Membrane Topology ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Nadph Cytochrome P450 Reductase

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Mutagenesis Study of Asp-290 in Cytochrome P450 2B11 Using a Fusion Protein with Rat NADPH-Cytochrome P450 Reductase

Archives of Biochemistry and Biophysics ◽

10.1006/abbi.1996.0050 ◽

1996 ◽

Vol 326 (1) ◽

pp. 85-92 ◽

Cited By ~ 26

Author(s):

Greg R. Harlow ◽

James R. Halpert

Keyword(s):

Cytochrome P450 ◽

Fusion Protein ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Nadph Cytochrome P450 Reductase ◽

Mutagenesis Study

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Catalytic and immunochemical properties of NADPH-cytochrome P450 reductase from fungus Rhizopus nigricans

The Journal of Steroid Biochemistry and Molecular Biology ◽

10.1016/s0960-0760(02)00145-0 ◽

2002 ◽

Vol 82 (1) ◽

pp. 89-96 ◽

Cited By ~ 12

Author(s):

Tomaž Makovec ◽

Katja Breskvar

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 Reductase ◽

Rhizopus Nigricans ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Nadph Cytochrome P450 Reductase

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