IN VITRO METABOLISM OF MK-0767 [(±)-5-[(2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[[(4-TRIFLUOROMETHYL)-PHENYL] METHYL]BENZAMIDE], A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α/γ AGONIST. II. IDENTIFICATION OF METABOLITES BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY

David Q. Liu; Bindhu V. Karanam; George A. Doss; Rick R. Sidler; Stella H. Vincent; Cornelis E.C.A. Hop

doi:10.1124/dmd.104.000059

IN VITRO METABOLISM OF MK-0767 [(±)-5-[(2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[[(4-TRIFLUOROMETHYL)-PHENYL] METHYL]BENZAMIDE], A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α/γ AGONIST. II. IDENTIFICATION OF METABOLITES BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY

Drug Metabolism and Disposition ◽

10.1124/dmd.104.000059 ◽

2004 ◽

Vol 32 (9) ◽

pp. 1023-1031 ◽

Cited By ~ 16

Author(s):

David Q. Liu ◽

Bindhu V. Karanam ◽

George A. Doss ◽

Rick R. Sidler ◽

Stella H. Vincent ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

In Vitro Metabolism ◽

Peroxisome Proliferator ◽

Tandem Mass ◽

Peroxisome Proliferator Activated Receptor ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

Download Full-text

Quantitative determination of MK-0767, a dual α/γ peroxisome proliferator-activated receptor (PPAR) agonist, in human plasma by liquid chromatography–tandem mass spectrometry

Journal of Chromatography B ◽

10.1016/s1570-0232(04)00564-1 ◽

2004 ◽

Vol 810 (1) ◽

pp. 7-13 ◽

Cited By ~ 3

Author(s):

H SONG ◽

K YAN ◽

X XU ◽

M LO

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Quantitative Determination ◽

Peroxisome Proliferator ◽

Tandem Mass ◽

Peroxisome Proliferator Activated Receptor ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

Download Full-text

A Novel Liquid Chromatography Tandem Mass Spectrometry Method for the Estimation of Bilirubin Glucuronides and its Application to In Vitro Enzyme Assays

Drug Metabolism Letters ◽

10.2174/1872312810666161124143522 ◽

2017 ◽

Vol 10 (4) ◽

pp. 264-269 ◽

Cited By ~ 1

Author(s):

Siva Putluru ◽

Murali Matta ◽

Deepak Ahire ◽

Murali Subramanian ◽

Michael Sinz ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Enzyme Assays ◽

Tandem Mass ◽

Spectrometry Method ◽

Mass Spectrometry Method ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

Download Full-text

In Vitro Evaluation of DNA Damage Effect Markers toward Five Nitrogen Mustards Based on Liquid Chromatography–Tandem Mass Spectrometry

Chemical Research in Toxicology ◽

10.1021/acs.chemrestox.1c00346 ◽

2021 ◽

Author(s):

Kexin Li ◽

Zehua Li ◽

Jianfeng Wu ◽

Ying Gong ◽

Lei Guo ◽

...

Keyword(s):

Mass Spectrometry ◽

Dna Damage ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Damage Effect ◽

Tandem Mass ◽

Nitrogen Mustards ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

Download Full-text

In vitro and in vivo metabolite identification of a novel benzimidazole compound ZLN005 by liquid chromatography/tandem mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.8060 ◽

2018 ◽

Vol 32 (6) ◽

pp. 480-488 ◽

Cited By ~ 2

Author(s):

Wenchao Sun ◽

Khoa Dinh Nguyen ◽

William L. Fitch ◽

Samuel D. Banister ◽

Hongxiang Tang ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Metabolite Identification ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

Download Full-text

Identification of in vivo and in vitro metabolites of triptolide by liquid chromatography–tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2012.06.026 ◽

2012 ◽

Vol 70 ◽

pp. 624-630 ◽

Cited By ~ 10

Author(s):

Zhi-hong Peng ◽

Jun-jun Wang ◽

Peng Du ◽

Yong Chen

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

Download Full-text

Identification of in-vivo and in-vitro metabolites of palmatine by liquid chromatography-tandem mass spectrometry

Journal of Pharmacy and Pharmacology ◽

10.1211/jpp/61.05.0014 ◽

2009 ◽

Vol 61 (5) ◽

pp. 647-652

Author(s):

Qian C. Yang ◽

Wen H. Wu ◽

Feng M. Han ◽

Yong Chen

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

Download Full-text

Ultra-performance liquid chromatography–tandem mass spectrometry for the determination of atypical antipsychotics and some metabolites in in vitro samples

Journal of Chromatography B ◽

10.1016/j.jchromb.2006.12.051 ◽

2007 ◽

Vol 850 (1-2) ◽

pp. 581-585 ◽

Cited By ~ 29

Author(s):

Kun-Yan Li ◽

Yan-Gang Zhou ◽

Hua-Yi Ren ◽

Feng Wang ◽

Bi-Kui Zhang ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Atypical Antipsychotics ◽

Ultra Performance Liquid Chromatography ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

Download Full-text

Liquid chromatography–tandem mass spectrometry method for simultaneous determination of three N-7-guanine adducts of the active epoxides of prodrug treosulfan in DNA in vitro

Talanta ◽

10.1016/j.talanta.2019.01.120 ◽

2019 ◽

Vol 198 ◽

pp. 464-471 ◽

Cited By ~ 1

Author(s):

Michał Romański ◽

Konrad Rotecki ◽

Bartosz Nowicki ◽

Artur Teżyk ◽

Franciszek K. Główka

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Tandem Mass ◽

Spectrometry Method ◽

Chromatography Tandem Mass Spectrometry ◽

Guanine Adducts ◽

Liquid Chromatography Tandem Mass

Download Full-text

Strategies to In Vitro Assessment of Major Human CYP Enzyme Activities by Using Liquid Chromatography Tandem Mass Spectrometry

Current Drug Metabolism ◽

10.2174/138920008783331112 ◽

2008 ◽

Vol 9 (1) ◽

pp. 12-19 ◽

Cited By ~ 29

Author(s):

A. Lahoz ◽

M. Donato ◽

J. Castell ◽

M. Gomez-Lechon

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Enzyme Activities ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass ◽

In Vitro Assessment

Download Full-text

Identification of in-vivo and in-vitro metabolites of palmatine by liquid chromatography-tandem mass spectrometry

Journal of Pharmacy and Pharmacology ◽

10.1211/jpp.61.05.0014 ◽

2009 ◽

Vol 61 (5) ◽

pp. 647-652 ◽

Cited By ~ 18

Author(s):

Qian C. Yang ◽

Wen H. Wu ◽

Feng M. Han ◽

Yong Chen

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

Download Full-text