Automated Exercise Blood Pressure Measurements in Children: A Preliminary Study

1991 ◽  
Vol 3 (4) ◽  
pp. 290-299 ◽  
Author(s):  
Frank A. Treiber ◽  
Francis McCaffrey ◽  
William B. Strong ◽  
Harry Davis ◽  
Tom Baranowski
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Treadmill Exercise ◽  
Preliminary Evidence ◽  
Mean Difference ◽  
Pressure Measurements ◽  
Postural Change ◽  
Active Recovery ◽  
Exercise Blood Pressure ◽  
Preliminary Study

This study compared blood pressure and heart rate measurements provided by the Quinton 410 automated exercise monitor with simultaneous auscultatory and electrocardiograph readings during rest, postural change, immediately after each treadmill exercise workload, and during active recovery in a sample of young children (mean age 7.9 yrs). The Quinton 410 provided highly accurate heart rates under all conditions (average mean difference <1.0 bpm). The Quinton systolic readings correlated well with and were similar to auscultation across conditions except for the initial treadmill workload. Slightly weaker relationships were observed between the Quinton and K4 diastolic comparisons. Compared with K4 auscultatory readings, the Quinton 410 provided slightly lower diastolic pressures across conditions (average mean difference = 3.1 mmHg). These findings provide preliminary evidence that for group comparisons with children, the Quinton 410 provides acceptable blood pressure estimates resulting from a variety of events, including exercise.

scholarly journals Sex and exercise-mode differences in post-exercise blood pressure and heart rate variability responses during a workday

2019 ◽  
Vol 25 (1) ◽  
Author(s):  
Igor Moraes Mariano ◽  
Daniela Coelho Domingos ◽  
Ana Luiza Amaral Ribeiro ◽  
Tiago Peçanha ◽  
Herbert Gustavo Simões ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Post Exercise ◽  
Exercise Mode ◽  
Exercise Blood Pressure

scholarly journals Autonomic modulation at rest and in response to postural change in adolescents with Duchenne muscular dystrophy: a cross-sectional study

2021 ◽  
Vol 79 (9) ◽  
pp. 766-773
Author(s):  
Mariana Viana Rodrigues ◽  
Mileide Cristina Stoco-Oliveira ◽  
Talita Dias da Silva ◽  
Celso Ferreira ◽  
Heloisa Balotari Valente ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Oxygen Saturation ◽  
Cross Sectional Study ◽  
Control Group ◽  
Autonomic Modulation ◽  
Postural Change ◽  
Cross Sectional

ABSTRACT Background: Analysis of autonomic modulation after postural change may inform the prognosis and guide treatment in different populations. However, this has been insufficiently explored among adolescents with Duchenne muscular dystrophy (DMD). Objective: To investigate autonomic modulation at rest and in response to an active sitting test (AST) among adolescents with DMD. Methods: Fifty-nine adolescents were included in the study and divided into two groups: 1) DMD group: adolescents diagnosed with DMD; 2) control group (CG): healthy adolescents. Participants’ weight and height were assessed. Lower limb function, motor limitations and functional abilities of the participants in the DMD group were classified using the Vignos scale, Egen classification and motor function measurement, respectively. The following variables were assessed before, during and after AST: systolic blood pressure (SBP), diastolic blood pressure (DBP), respiratory rate (f), oxygen saturation and heart rate (HR). To analyze the autonomic modulation, the HR was recorded beat-by-beat. Heart rate variability (HRV) indices were calculated in the time and frequency domains. Results: Differences in relation to groups were observed for all HRV indices, except LF/HF, oxygen saturation, HR and f (p < 0.05). Differences in relation to time and the interaction effect between group and time were observed for RMSSD, SD1, SD2, SD1/SD2, LFms2 and LFnu, HFun, SBP and DBP (p < 0.05). Differences in relation to time were also observed for the indice SDNN, FC and f (p < 0.05). Conclusions: Performing the AST promoted reduced autonomic modulation and increased SBP, DBP and HR in adolescents with DMD.

0744 Cardiac Safety Profile of Pitolisant in Patients with Narcolepsy

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A283-A283
Author(s):  
W Winter ◽  
S P Wanaski ◽  
A Patroneva ◽  
J M Dayno
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Pooled Analysis ◽  
Mean Difference ◽  
Qtc Interval ◽  
Cardiac Safety ◽  
Open Label ◽  
Long Term Study ◽  
End Of Treatment

Abstract Introduction Cardiovascular diseases are comorbid in patients with narcolepsy. Cardiovascular adverse effects are of concern with narcolepsy medications because of this comorbidity and most patients require lifelong pharmacotherapy. Pitolisant, a selective histamine 3 (H3)-receptor antagonist/inverse agonist, increases histamine transmission in the brain. In a QT study of healthy volunteers, pitolisant (35.6 mg/day) led to a mean increase of 4.2 msec in QTc interval. This analysis further characterized the cardiac safety of pitolisant (maximum dose, 35.6 mg/day) in adults with narcolepsy. Methods Data were obtained from a pooled analysis of 2 randomized, placebo-controlled, 7- or 8-week studies and from a 12-month, open-label study. Results Pooled analysis included 166 patients (pitolisant, n=85; placebo, n=81). Mean change in heart rate from baseline to end-of-treatment was -0.5 beats/min with pitolisant and -0.2 beats/min with placebo (LS mean difference, -0.4; P=0.744). Mean change was also similar for pitolisant versus placebo in systolic (LS mean difference, 0.0; P=0.983) and diastolic (LS mean difference, -0.6; P=0.552) blood pressure, as was mean change in QTc interval (LS mean difference, 0.4; P=0.911). Cardiac adverse events with pitolisant included heart rate increase (n=4), right bundle branch block (n=1), sinus tachycardia (n=1), and palpitations (n=1), and with placebo included blood pressure increase (n=1). In the long-term study, mean change from baseline in QTc interval was 3.1 msec at Month 6 (n=70) and 6.1 msec at Month 12 (n=67); 3 patients had a postbaseline increase &gt;60 msec but none had QTc &gt;500 msec. Conclusion In this analysis, no cardiac safety signals were observed during treatment with pitolisant administered up to the maximum recommended dose. Because concomitant use of pitolisant with other drugs known to increase the QT interval may add to the QT effects of pitolisant, avoid use of pitolisant in combination with these medications. Support Bioprojet Pharma and Harmony Biosciences, LLC.

Effects of chronic cetamolol therapy on resting, ambulatory, and exercise blood pressure and heart rate

1986 ◽  
Vol 39 (6) ◽  
pp. 664-668 ◽  
Author(s):  
William B White ◽  
Peter Schulman ◽  
Ellen J McCabe ◽  
W David Hager
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Exercise Blood Pressure

scholarly journals Increase of Short-Term Heart Rate Variability Induced by Blood Pressure Measurements during Ambulatory Blood Pressure Monitoring

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Attila Frigy ◽  
Annamária Magdás ◽  
Victor-Dan Moga ◽  
Ioana Georgiana Coteț ◽  
Miklós Kozlovszky ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Ambulatory Blood Pressure ◽  
Pressure Measurement ◽  
Blood Pressure Monitoring ◽  
Blood Pressure Measurement ◽  
Pressure Measurements ◽  
Pressure Monitoring ◽  
Short Term

Objective.The possible effect of blood pressure measurements per se on heart rate variability (HRV) was studied in the setting of concomitant ambulatory blood pressure monitoring (ABPM) and Holter ECG monitoring (HM).Methods.In 25 hypertensive patients (14 women and 11 men, mean age: 58.1 years), 24-hour combined ABPM and HM were performed. For every blood pressure measurement, 2-minute ECG segments (before, during, and after measurement) were analyzed to obtain time domain parameters of HRV: SDNN and rMSSD. Mean of normal RR intervals (MNN), SDNN/MNN, and rMSSD/MNN were calculated, too. Parameter variations related to blood pressure measurements were analyzed using one-way ANOVA with multiple comparisons.Results.2281 measurements (1518 during the day and 763 during the night) were included in the analysis. Both SDNN and SDNN/MNN had a constant (the same for 24-hour, daytime, and nighttime values) and significant change related to blood pressure measurements: an increase during measurements and a decrease after them (p<0.01for any variation).Conclusion.In the setting of combined ABPM and HM, the blood pressure measurement itself produces an increase in short-term heart rate variability. Clarifying the physiological basis and the possible clinical value of this phenomenon needs further studies.

Modeling baroreflex regulation of heart rate during orthostatic stress

2006 ◽  
Vol 291 (5) ◽  
pp. R1355-R1368 ◽  
Author(s):  
Mette S. Olufsen ◽  
Hien T. Tran ◽  
Johnny T. Ottesen ◽  
Lewis A. Lipsitz ◽  
Vera Novak
Keyword(s):  
Blood Pressure ◽  
Mathematical Model ◽  
Heart Rate ◽  
Hysteresis Loop ◽  
Elderly People ◽  
Elderly Subjects ◽  
Orthostatic Stress ◽  
Postural Change ◽  
Heart Rate Regulation ◽  
Heart Rate Dynamics

During orthostatic stress, arterial and cardiopulmonary baroreflexes play a key role in maintaining arterial pressure by regulating heart rate. This study presents a mathematical model that can predict the dynamics of heart rate regulation in response to postural change from sitting to standing. The model uses blood pressure measured in the finger as an input to model heart rate dynamics in response to changes in baroreceptor nerve firing rate, sympathetic and parasympathetic responses, vestibulo-sympathetic reflex, and concentrations of norepinephrine and acetylcholine. We formulate an inverse least squares problem for parameter estimation and successfully demonstrate that our mathematical model can accurately predict heart rate dynamics observed in data obtained from healthy young, healthy elderly, and hypertensive elderly subjects. One of our key findings indicates that, to successfully validate our model against clinical data, it is necessary to include the vestibulo-sympathetic reflex. Furthermore, our model reveals that the transfer between the nerve firing and blood pressure is nonlinear and follows a hysteresis curve. In healthy young people, the hysteresis loop is wide, whereas, in healthy and hypertensive elderly people, the hysteresis loop shifts to higher blood pressure values, and its area is diminished. Finally, for hypertensive elderly people, the hysteresis loop is generally not closed, indicating that, during postural change from sitting to standing, baroreflex modulation does not return to steady state during the first minute of standing.

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