Inter-digit Individuation and Force Variability in the Precision Grip of Young, Elderly, and Parkinson's Disease Participants

Motor Control ◽  
2002 ◽  
Vol 6 (2) ◽  
pp. 113-128 ◽  
Author(s):  
David E. Vaillancourt ◽  
Andrew B. Slifkin ◽  
Karl M. Newell
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Precision Grip ◽  
Force Variability

Dynamic Fingertip Force Variability in Individuals With Parkinson’s Disease

2016 ◽  
Vol 29 (2) ◽  
pp. e8 ◽  
Author(s):  
Na-Hyeon Ko ◽  
Christopher M. Laine ◽  
Beth E. Fisher ◽  
Francisco J. Valero-Cuevas
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Force Variability ◽  
Fingertip Force

scholarly journals Fine Manual Dexterity Assessment After Autologous Neural Cell Ecosystem (ANCE) Transplantation in a Non-human Primate Model of Parkinson’s Disease

2019 ◽  
Vol 33 (7) ◽  
pp. 553-567 ◽  
Author(s):  
Simon Borgognon ◽  
Jérôme Cottet ◽  
Véronique Moret ◽  
Pauline Chatagny ◽  
Laura Carrara ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Recovery ◽  
Rating Scales ◽  
Precision Grip ◽  
Subjective Assessment ◽  
Neural Cell ◽  
Manual Dexterity ◽  
Primate Model ◽  
The Impact

Background. Autologous neural cell ecosystem (ANCE) transplantation improves motor recovery in MPTP monkeys. These motor symptoms were assessed using semi-quantitative clinical rating scales, widely used in many studies. However, limitations in terms of sensitivity, combined with relatively subjective assessment of their different items, make inter-study comparisons difficult to achieve. Objective. The aim of this study was to quantify the impact of MPTP intoxication in macaque monkeys on manual dexterity and assess whether ANCE can contribute to functional recovery. Methods. Four animals were trained to perform 2 manual dexterity tasks. After reaching a motor performance plateau, the animals were subjected to an MPTP lesion. After the occurrence of a spontaneous functional recovery plateau, all 4 animals were subjected to ANCE transplantation. Results. Two of 4 animals underwent a full spontaneous recovery before the ANCE transplantation, whereas the 2 other animals (symptomatic) presented moderate to severe Parkinson’s disease (PD)-like symptoms affecting manual dexterity. The time to grasp small objects using the precision grip increased in these 2 animals. After ANCE transplantation, the 2 symptomatic animals underwent a significant functional recovery, reflected by a decrease in time to execute the different tasks, as compared with the post-lesion phase. Conclusions. Manual dexterity is affected in symptomatic MPTP monkeys. The 2 manual dexterity tasks reported here as pilot are pertinent to quantify PD symptoms and reliably assess a treatment in MPTP monkeys, such as the present ANCE transplantation, to be confirmed in a larger cohort of animals before future clinical applications.

scholarly journals Precision grip and Parkinson's disease

Brain ◽  
1998 ◽  
Vol 121 (9) ◽  
pp. 1771-1784 ◽  
Author(s):  
S. Fellows
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Precision Grip

Interrelations between cognitive dysfunction and motor symptoms of Parkinson’s disease: behavioral and neural studies

2016 ◽  
Vol 27 (5) ◽  
pp. 535-548 ◽  
Author(s):  
Ahmed A. Moustafa ◽  
Srinivasa Chakravarthy ◽  
Joseph R. Phillips ◽  
Jacob J. Crouse ◽  
Ankur Gupta ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Dysfunction ◽  
Cognitive Deficits ◽  
Cognitive Rehabilitation ◽  
Precision Grip ◽  
Motor Deficits ◽  
Motor Symptoms ◽  
Rehabilitation Programs ◽  
Cardinal Symptoms

AbstractParkinson’s disease (PD) is characterized by a range of motor symptoms. Besides the cardinal symptoms (tremor, bradykinesia/akinesia, and rigidity), PD patients also show other motor deficits, including gait disturbance, speech deficits, and impaired handwriting. However, along with these key motor symptoms, PD patients also experience cognitive deficits in attention, executive function, working memory, and learning. Recent evidence suggests that these motor and cognitive deficits of PD are not completely dissociable, as aspects of cognitive dysfunction can impact motor performance in PD. In this article, we provide a review of behavioral and neural studies on the associations between motor symptoms and cognitive deficits in PD, specifically akinesia/bradykinesia, tremor, gait, handwriting, precision grip, and speech production. This review paves the way for providing a framework for understanding how treatment of cognitive dysfunction, for example cognitive rehabilitation programs, may in turn influence the motor symptoms of PD.

scholarly journals Combined measures of movement and force variability distinguish Parkinson’s disease from essential tremor

2011 ◽  
Vol 122 (11) ◽  
pp. 2268-2275 ◽  
Author(s):  
Cynthia Poon ◽  
Julie A. Robichaud ◽  
Daniel M. Corcos ◽  
Jennifer G. Goldman ◽  
David E. Vaillancourt
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Essential Tremor ◽  
Force Variability

The effect of subthalamic nucleus deep brain stimulation on precision grip abnormalities in Parkinson's disease

2006 ◽  
Vol 12 (3) ◽  
pp. 149-154 ◽  
Author(s):  
Stuart J. Fellows ◽  
Martin Kronenbürger ◽  
Niels Allert ◽  
Volker A. Coenen ◽  
Christoph Fromm ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Precision Grip ◽  
Deep Brain
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