Adults Engaged in Sports in Early Life Have Higher Bone Mass Than Their Inactive Peers

2018 ◽  
Vol 15 (7) ◽  
pp. 516-522 ◽  
Author(s):  
Alessandra Madia Mantovani ◽  
Manoel Carlos Spiguel de Lima ◽  
Luis Alberto Gobbo ◽  
Enio Ricardo Vaz Ronque ◽  
Marcelo Romanzini ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mass ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Early Life ◽  
Mineral Content ◽  
Sports Participation ◽  
Activity Level ◽  
Whole Body ◽  
Mineral Density

Purpose: To analyze the relationship between engagement in sports in early life and bone variables among adults of both sexes. Methods: The sample was composed of 225 men and women. Demographic data were collected, and dual-energy X-ray absorptiometry was used to assess bone mineral density, bone mineral content, and lean soft tissue. Sports participation in early life was assessed by an interview including childhood and adolescence. Consumption of tobacco and alcohol was also assessed by interview and the habitual physical activity level by a pedometer. Results: Inactive men had bone mineral content around 11% lower than active men in childhood or adolescence, whereas for women, this difference represented around 14%. Active men had 74% less fat mass than inactive men in early life, and the difference was 67% for women. Early sports participation explained the differences in whole-body bone mineral content (16.8%, P-value = .005) and bone mineral density (8.8%, P-value = .015), as well as bone mineral density in lower limbs (18.9%, P-value = .001) among women. Conclusion: Adults engaged in sports in early life have higher bone mass than their inactive peers, especially women.

scholarly journals Daily Treatment with Human Recombinant Parathyroid Hormone-(1–34), LY333334, for 1 Year Increases Bone Mass in Ovariectomized Monkeys*

1999 ◽  
Vol 84 (10) ◽  
pp. 3757-3763 ◽  
Author(s):  
Robert Brommage ◽  
Charlotte E. Hotchkiss ◽  
Cynthia J. Lees ◽  
Melanie W. Stancill ◽  
Janet M. Hock ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Proximal Tibia ◽  
Whole Body ◽  
Mineral Density ◽  
Increase Bone Mass ◽  
Skeletal Effects ◽  
Body Bone

AbstractPTH stimulates bone formation to increase bone mass and strength in rats and humans. The aim of this study was to determine the skeletal effects of recombinant human PTH-(1–34) [rhPTH-(1–34)] in monkeys, as monkey bone remodeling and structure are similar to those in human bone.Adult female cynomolgus monkeys were divided into sham-vehicle (n= 21), ovariectomized (OVX)-vehicle (n = 20), and OVX groups given daily sc injections of rhPTH-(1–34) at 1 (n = 39) or 5 (n = 41) μg/kg for 12 months. Whole body bone mineral content was measured, as was bone mineral density (BMD) in the spine, proximal tibia, midshaft radius, and distal radius. Serum and urine samples were also analyzed. rhPTH-(1–34) treatment did not influence serum ionized Ca levels or urinary Ca excretion, but depressed endogenous PTH while increasing serum calcitriol levels. Compared to that in the OVX group, the higher dose of rhPTH-(1–34) increased spine BMD by 14.3%, whole body bone mineral content by 8.6%, and proximal tibia BMD by 10.8%. Subregion analyses suggested that the anabolic effect of rhPTH-(1–34) on the proximal tibia was primarily in cancellous bone. Similar, but less dramatic, effects on BMD were observed with the lower dose of rhPTH-(1–34). Daily sc rhPTH-(1–34) treatment for 1 yr increases BMD in ovariectomized monkeys without inducing sustained hypercalcemia or hypercalciuria.

Effects of tower climbing exercise on bone mass, strength, and turnover in orchidectomized growing rats

2002 ◽  
Vol 93 (3) ◽  
pp. 1152-1158 ◽  
Author(s):  
Takuya Notomi ◽  
Yuichi Okazaki ◽  
Nobukazu Okimoto ◽  
Yuri Tanaka ◽  
Toshitaka Nakamura ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Formation ◽  
Bone Mass ◽  
Bone Mineral Content ◽  
Trabecular Bone ◽  
Bone Mineral ◽  
Mineral Content ◽  
Lumbar Vertebrae ◽  
Mineral Density ◽  
Sedentary Group

To determine the effects of a tower climbing exercise on mass, strength, and local turnover of bone, 70 9-wk-old Sprague-Dawley rats were assigned to seven groups: a baseline control and three groups of sham-operated sedentary, orchidectomized (ORX)-sedentary and ORX-exercise rats. Rats voluntarily climbed a 200-cm tower to drink water from a bottle set at the top. At 4 wk, the periosteal bone formation rate (BFR), moment of inertia, bone mineral content, bone mineral density, and bending load at the midfemur were maintained in ORX-exercise rats, whereas these parameters were reduced in ORX-sedentary rats. At 8 wk, the periosteal mineral apposition rate and BFR in ORX-exercise rats were significantly higher, whereas the parameters in ORX-sedentary rats did not differ compared with sham-sedentary rats. In ORX-exercise rats, the trabecular mineralizing surface, BFR, and bone volume of the lumbar vertebrae were maintained at the same levels as those in the sham-sedentary group, whereas the osteoclast surface decreased compared with the ORX-sedentary group. However, the climbing exercise did not affect bone mineral content, bone mineral density, or the compression load of the lumbar vertebrae. These results show that, in the midfemur, the voluntary climbing exercise maintained cortical bone mass and strength by stimulating periosteal bone formation and partially prevented ORX-induced trabecular bone loss, depressing the elevation of turnover. Interestingly, in ORX rats, the climbing exercise had the opposite effect on bone formation at the periosteal femoral cortical bone, where the exercise increased the bone formation compared with vertebral trabecular bone, where the exercise decreased it.

Estrogen Receptor α Polymorphism Modifies the Association between Childhood Exercise and Bone Mass: Follow-Up Study

2007 ◽  
Vol 19 (4) ◽  
pp. 444-458 ◽  
Author(s):  
Miia Suuriniemi ◽  
Harri Suominen ◽  
Anitta Mahonen ◽  
Markku Alén ◽  
Sulin Cheng
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Bone Mass ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Areal Bone Mineral Density ◽  
Mineral Density ◽  
Follow Up Study

This follow-up study confirms our previous findings that the ER-α PvuII polymorphism (Pp) modulates the association between exercise and bone mass. The differences in bone properties of girls with consistently low physical activity (LLPA) and consistently high physical activity (HHPA) were evident only in those bearing the heterozygote ER-α genotype (Pp). In particular, areal bone mineral density of the total femur, bone mineral content and areal bone mineral density of the femoral neck, and bone mineral content and cortical thickness of the tibia shaft were significantly (p < .05) lower in the Pp girls with LLPA than in their HHPA counterparts. These findings might partly explain the genetic basis of human variation associated with exercise training.

Influence of anthropometric parameters on assessment of paediatric bone mineral density and bone mineral content

2013 ◽  
Author(s):  
N Hangartner Thomas ◽  
F Short David ◽  
Gilsanz Vicente ◽  
J Kalkwarf Heidi ◽  
M Lappe Joan ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Mineral Density ◽  
Anthropometric Parameters

Effects of One-Year Adjuvant Treatment with Tamoxifen on Bone Mineral Density in Postmenopausal Breast Cancer Women

1996 ◽  
Vol 82 (1) ◽  
pp. 65-67 ◽  
Author(s):  
Sandro Barni ◽  
Paolo Lissoni ◽  
Gabriele Tancini ◽  
Antonio Ardizzoia ◽  
Marina Cazzaniga
Keyword(s):  
Breast Cancer ◽  
Bone Mineral Density ◽  
Alkaline Phosphatase ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Adjuvant Treatment ◽  
Mineral Content ◽  
Postmenopausal Breast Cancer ◽  
Mineral Density ◽  
One Year

In this study, the authors have analyzed the possible effects of one-year adjuvant treatment with tamoxifen on bone mineral density in postmenopausal breast cancer women. Bone mineral content was studied by photon absorptiometry (I-125), whereas bone balance was analyzed indirectly by serum PTH, osteocalcin, calcitonin, calcium and alkaline phosphatase levels. Bone mineral content and serum bone-related substances were measured before starting treatment and after one year. Results were analyzed using Student's t test for paired data. No difference was found between the two measurements for bone mineral content, PTH, calcitonin, calcium and alkaline phosphatase levels. Measurements at entry and after one year of treatment showed a statistically significant difference ( P < 0.001) only for osteocalcin. In accordance with other authors, we can conclude that treatment with tamoxifen does not cause an increase in menopausal bone resorption. The finding that osteocalcin levels decreased after one year of therapy with tamoxifen is interesting, but further studies are necessary to clarify the role of such levels in predicting a turnover of bone balance towards osteoblastic activity.

Decreased Bone Density in Adolescent Girls With Anorexia Nervosa

PEDIATRICS ◽  
1990 ◽  
Vol 86 (3) ◽  
pp. 440-447 ◽  
Author(s):  
Laura K. Bachrach ◽  
David Guido ◽  
Debra Katzman ◽  
Iris F. Litt ◽  
Robert Marcus
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Anorexia Nervosa ◽  
Bone Density ◽  
Bone Mass ◽  
Body Mass ◽  
Bone Mineral ◽  
Whole Body ◽  
Mineral Density ◽  
Control Subjects

Osteoporosis develops in women with chronic anorexia nervosa. To determine whether bone mass is reduced in younger patients as well, bone density was studied in a group of adolescent patients with anorexia nervosa. With single- and dual-photon absorptiometry, a comparison was made of bone mineral density of midradius, lumbar spine, and whole body in 18 girls (12 to 20 years of age) with anorexia nervosa and 25 healthy control subjects of comparable age. Patients had significantly lower lumbar vertebral bone density than did control subjects (0.830 ± 0.140 vs 1.054 ± 0.139 g/cm2) and significantly lower whole body bone mass (0.700 ± 0.130 vs 0.955 ± 0.130 g/cm2). Midradius bone density was not significantly reduced. Of 18 patients, 12 had bone density greater than 2 standard deviations less than normal values for age. The diagnosis of anorexia nervosa had been made less than 1 year earlier for half of these girls. Body mass index correlated significantly with bone mass in girls who were not anorexic (P &lt; .05, .005, and .0001 for lumbar, radius, and whole body, respectively). Bone mineral correlated significantly with body mass index in patients with anorexia nervosa as well. In addition, age at onset and duration of anorexia nervosa, but not calcium intake, activity level, or duration of amenorrhea correlated significantly with bone mineral density. It was concluded that important deficits of bone mass occur as a frequent and often early complication of anorexia nervosa in adolescence. Whole body is considerably more sensitive than midradius bone density as a measure of cortical bone loss in this illness. Low body mass index is an important predictor of this reduction in bone mass.

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