Effect of Exercise on Inflammatory Profile of Older Persons: Systematic Review and Meta-Analyses

2018 ◽  
Vol 15 (1) ◽  
pp. 64-71 ◽  
Author(s):  
Renato Sobral Monteiro-Junior ◽  
Paulo de Tarso Maciel-Pinheiro ◽  
Eduardo da Matta Mello Portugal ◽  
Luiz Felipe da Silva Figueiredo ◽  
Rodrigo Terra ◽  
...  
Keyword(s):  
Older Persons ◽  
Acute Phase Proteins ◽  
Random Effect ◽  
The Elderly ◽  
Low Grade ◽  
Elderly Persons ◽  
Chronic Exercise ◽  
Reactive Protein ◽  
Inflammatory Profile ◽  
Meta Analyses

Background: Inflammatory cytokines and acute phase proteins increase with aging, promoting a chronic low-grade inflammation. Studies have shown a positive effect of exercise on inflammatory markers in older persons. Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) are the main biomarkers investigated. However, it is unclear if exercise could decrease all these biomarkers. Purpose: The aim was to analyze the effect of chronic exercise on IL-6, TNF-α, and CRP levels in older persons. Methods: Preferred Reporting Items in Systematic Reviews and Meta-analyses guidelines were adopted. Original articles that investigated the effect of chronic exercise on inflammatory profile of the elderly persons were eligible for this review. The databases PubMed, PEDro, EBSCO, and BioMed Central were searched. Three reviewers evaluated each publication for reducing bias. Data about IL-6, TNF-α, and CRP were collected and analyzed. A standardized mean difference based on estimated pooled effect size was calculated considering heterogeneity index (I2) and random effect. Results: Seventy-six studies were retrieved from databases, and 8 of them were analyzed. IL-6 and CRP levels decreased after chronic exercise (overall effect P < .05). Conclusion: Regular exercise decreases IL-6 and CRP levels in older persons. The effect of exercise on TNF-α remains unclear.

scholarly journals The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3696
Author(s):  
Edyta Wawrzyniak-Gramacka ◽  
Natalia Hertmanowska ◽  
Anna Tylutka ◽  
Barbara Morawin ◽  
Eryk Wacka ◽  
...  
Keyword(s):  
Physical Performance ◽  
Systemic Inflammation ◽  
The Elderly ◽  
Diet Analysis ◽  
Low Grade ◽  
Dietary Recall ◽  
Reactive Protein ◽  
Anti Inflammatory ◽  
High Concentrations ◽  
Inflammatory Profile

One of the latest theories on ageing focuses on immune response, and considers the activation of subclinical and chronic inflammation. The study was designed to explain whether anti-inflammatory diet and lifestyle exercise affect an inflammatory profile in the Polish elderly population. Sixty individuals (80.2 ± 7.9 years) were allocated to a low-grade inflammation (LGI n = 33) or high-grade inflammation (HGI n = 27) group, based on C-reactive protein concentration (<3 or ≥3 mg/L) as a conventional marker of systemic inflammation. Diet analysis focused on vitamins D, C, E, A, β-carotene, n-3 and n-6 PUFA using single 24-h dietary recall. LGI demonstrated a lower n-6/n-3 PUFA but higher vitamin D intake than HGI. Physical performance based on 6-min walk test (6MWT) classified the elderly as physically inactive, whereby LGI demonstrated a significantly higher gait speed (1.09 ± 0.26 m/s) than HGI (0.72 ± 0.28 m/s). Circulating interleukins IL-1β, IL-6, IL-13, TNFα and cfDNA demonstrated high concentrations in the elderly with low 6MWT, confirming an impairment of physical performance by persistent systemic inflammation. These findings reveal that increased intake of anti-inflammatory diet ingredients and physical activity sustained throughout life attenuate progression of inflammaging in the elderly and indicate potential therapeutic strategies to counteract pathophysiological effects of ageing.

scholarly journals PETANDA PERADANGAN hs CRP DENGAN HIPERTENSI

2018 ◽  
Vol 15 (3) ◽  
pp. 91
Author(s):  
Suswanto . ◽  
Siti Muchayat P
Keyword(s):  
Vascular Reactivity ◽  
The Elderly ◽  
Low Grade ◽  
Elderly Persons ◽  
Cross Sectional ◽  
Blood Pressure Elevation ◽  
Reactive Protein ◽  
Hs Crp ◽  
Cross Sectional Design ◽  
High Degree

The major pathophysiologic mechanisms of hypertension include the activation of sympathetic nervous system and rennin–angiotensin–aldosterone system. Endothelial dysfunction, increased vascular reactivity, and vascular remodeling may cause that matter,rather than its consequences, of blood pressure elevation; increased vascular stiffness, which contributes to isolate systolic hypertensionin the elderly persons. Chronic low grade inflammation has been identified as an integral part in the pathogenesis of vascular disease.Inflammation may also be implicated in the development of hypertension. Several studies have demonstrated a significant relationshipbetween hs-CRP and stiffness of large arteries. If inflammation is truly linked to hypertension, then it would be reasonable to assume thatdrugs with anti-inflammatory actions may be able to arrest inflammation, improve endothelial function and lowering blood pressurein patients with hypertension. The aim of this cross sectional design study is to observe high sensitive C-reactive protein (hs-CRP)inflammatory markers in thirty five patients with hypertension. also want to know the present correlation between marker inflammationhs CRP with hypertension. With examine to some confounding factors as LDL, GDR and WBC. The results of this study showed that thereis no correlation between hs-CRP and hypertension, especially the duration of hypertension (r = 0.5 and p = 0.002). High degree ofhypertension was not followed by the increasing level of hs CRP.

Prevalence and Correlates of Depression in Elderly Persons

1980 ◽  
Vol 47 (3_suppl) ◽  
pp. 1055-1061 ◽  
Author(s):  
Edward F. Raymond ◽  
Timothy J. Michals ◽  
Robert A. Steer
Keyword(s):  
Health Care ◽  
Regression Analysis ◽  
Health Care Providers ◽  
Older Persons ◽  
Stepwise Regression ◽  
The Elderly ◽  
Elderly Persons ◽  
Care Providers ◽  
Self Assessment ◽  
Psychiatric Intervention

A sample of 504 elderly persons living within a metropolitan area were questioned about their socio-medical characteristics and administered the Wakefield Self-assessment Depression Inventory. The distribution of depression scores indicated that 34.5% were depressed. Stepwise regression analysis was next used to examine the relationships between the characteristics and depression scores. Total number of self-reported symptoms and being partially housebound were positively associated with depression. Recommendations were made that health care providers for the elderly be alerted that older persons with physical complaints and those who are partially restricted to their homes may tend to develop levels of depression which might require psychiatric intervention.

HIV and the Elderly

1994 ◽  
Vol 75 (6) ◽  
pp. 362-372 ◽  
Author(s):  
Nathan L. Linsk
Keyword(s):  
Social Support ◽  
Human Service ◽  
Older Persons ◽  
Family Care ◽  
Hiv Infections ◽  
The Elderly ◽  
Sexual Contact ◽  
Blood Transfusions ◽  
Elderly Persons ◽  
Support Family

A substantial and increasing number of people have developed HIV infections in their later years, most associated with male-to-male sexual contact or blood transfusions, although transmission also occurs through substance users and unsafe heterosexual activity. Human service practitioners need to become sensitive to the needs of elderly people and their families who are affected by HIV/AIDS. Prevention may be incorporated as part of initial engagement and assessment of elderly persons, and service packages may be developed for older persons who are infected or provide care for HIV-infected persons. Issues of confidentiality, social support, family care, and nondiscrimination are critical concerns in serving this population.

scholarly journals Factors associated with the frequency of polypathology among elderly persons receiving care at a referral center in Montes Claros, Minas Gerais

2016 ◽  
Vol 19 (4) ◽  
pp. 661-669
Author(s):  
Thaynara Rocha de Souza ◽  
Maria Aparecida Vieira ◽  
Fernanda Marques da Costa ◽  
Cássio de Almeida Lima
Keyword(s):  
Multivariate Analysis ◽  
Medical Records ◽  
Older Persons ◽  
The Elderly ◽  
Minas Gerais ◽  
Elderly Persons ◽  
Elderly Men ◽  
Cross Sectional ◽  
Referral Center ◽  
Appropriate Care

Abstract Objective: To investigate polypathology among elderly persons treated at a referral center in the state of Minas Gerais, Brazil. Methodology: An analytical documentary study with a cross-sectional quantitative approach was performed. The records of referral and care of 668 elderly persons who were treated at the referral center were analyzed. Bivariate and multivariate analysis was performed using logistic regression. Results: 278 medical records were analyzed. Polypathology was the main reason for seeking care in 114 (41.0%) cases. There was a statistically significant association between the characteristics of being male and less educated and polypathology. In multivariate analysis, polypathology was higher among men and lower among elderly persons with a high school or higher education. Conclusion: The findings identify a situation with a predominance of polypathology among the elderly. This is at a worrying level among elderly men and less educated older persons, and should be addressed carefully by health professionals, in the search for more specific and appropriate care.

scholarly journals Inflammatory markers, sarcopenia and its diagnostic criteria among the elderly: a systematic review

2017 ◽  
Vol 20 (3) ◽  
pp. 441-453 ◽  
Author(s):  
Karen Mello de Mattos Margutti ◽  
Natielen Jacques Schuch ◽  
Carla Helena Augustin Schwanke
Keyword(s):  
Systematic Review ◽  
Diagnostic Criteria ◽  
Physical Performance ◽  
Gait Speed ◽  
Inflammatory Markers ◽  
Handgrip Strength ◽  
The Elderly ◽  
Elderly Persons ◽  
Reactive Protein ◽  
European Working

Abstract Objective: To identify the relationship between inflammatory markers and sarcopenia, and the diagnostic criteria of the condition among the elderly. Methods: A systematic review was performed based on the consultation of the PubMed and LILACS databases. Eligible original articles were those involving individuals aged 60 years or more, which investigated sarcopenia [low muscle mass (MM) associated with poor muscle strength and/or reduced physical performance, according to the European Working Group on Sarcopenia in Older People consensus (EWGSOP)] or its diagnostic criteria, published in English or Portuguese, between 2010-2015. Results: Four articles were included in the review, the principle results of which were: the growth differentiation factor (GDF-15) exhibited a negative correlation with MM, handgrip strength and gait speed; the insulin-like growth factor-1 (IGF-1) correlated positively with MM; follistatin exhibited a weak correlation with physical performance; activin A and myostatin did not correlate with the diagnostic criteria; the highest tercile of extracellular heat shock protein 72 (eHsp72) was associated with lower median levels of MM, handgrip strength and gait speed; elderly persons with low MM had higher serum ferritin concentrations; women with low MM exhibited lower serum concentration levels of C-reactive protein (CRP). Conclusion: the six investigated inflammatory markers (GDF-15, IGF-1, follistatin, eHsp72, ferritin and CRP) were associated with the diagnostic criteria for sarcopenia, but not with sarcopenia itself. As research in this area is still developing, additional studies are required to broaden knowledge and eventually establish the role of these markers in the diagnosis and management of sarcopenia.

Muscle Synergy Analysis Between Young and Elderly People in Standing-Up Motion

2013 ◽  
Vol 25 (6) ◽  
pp. 1038-1049 ◽  
Author(s):  
Qi An ◽  
◽  
Yusuke Ikemoto ◽  
Hajime Asama
Keyword(s):  
Motor Function ◽  
Older Persons ◽  
The Elderly ◽  
Joint Torque ◽  
Daily Activities ◽  
Muscle Synergy ◽  
Elderly Persons ◽  
Muscle Coordination ◽  
Important Data ◽  
Standing Up

Standing up is fundamental to daily activities of the elderly. It is necessary both to enhance muscle strength and to strengthen muscle coordination for improvement of their motor function. In this paper, we extract important data related to muscle coordination, called synergy, to perform standing motion by young and elderly participants. The contribution of muscle synergy to body kinematics is calculated through neural networks that estimate joint torque and body kinematics. To explain deficient motor function in elderly persons, extracted synergy is classified into 4 clusters based on how synergy contribute to body kinematics. Cluster analysis explains that elderly participants have weaker synergy than young persons in bending their backs to generate momentum. Compared to younger persons, older persons require additional muscle coordination to stabilize posture after standing-up in order to avoid falling.

Memorial Contributions: Remembering the Elderly Deceased and Supporting the Bereaved

1991 ◽  
Vol 23 (3) ◽  
pp. 169-179 ◽  
Author(s):  
Gerald L. Euster
Keyword(s):  
Older Persons ◽  
Educational Leaders ◽  
The Elderly ◽  
Elderly Persons ◽  
Religious Institutions ◽  
Community Programs ◽  
Written Comments ◽  
In Memoriam ◽  
Research Questions ◽  
Bereaved Family

While there is considerable evidence that many older persons decline in interpersonal and physical functioning following spousal or sibling losses, little is known about customary forms of support to facilitate the management of bereavement. This study explores the importance of the widely used ritual of “In Memoriam” contributions as a remembrance of deceased elderly persons and support for bereaved family and friends. Answers to two research questions were sought. First, what types of memorial contributions were requested by the bereaved on behalf of deceased elderly South Carolinians during an eight-month period, as published in statewide newspaper obituaries? Second, how do religious, social agency, health care, and educational leaders and administrators perceive the importance of memorial contributions as they impact upon the bereaved following funerals of elderly persons? The findings indicated that in 2, 198 obituaries, 68.2 percent of the families designated contributions to religious institutions and 22.1 percent to health associations/foundations. Rankings by study respondents and additional written comments indicated that memorials were most helpful to the extent that they offered comfort and support to bereaved family, reconfirmed friendship ties, and helped to continue funding for religious and other community programs valued by the deceased. The findings suggest that memorials help in the grief work of many families and provide some tangible repayment for expressions of concern and generosity extended to the deceased and bereaved.

scholarly journals Anemia and the frailty syndrome amongst the elderly living in the community: a systematic review

2018 ◽  
Vol 21 (2) ◽  
pp. 223-231
Author(s):  
Elisa Priscila Sousa de Assis ◽  
Barbara Gazolla de Macêdo ◽  
Hanna Sette Camara de Oliveira ◽  
Poliana de Paula Dias Rezende ◽  
Carlos Maurício Figueiredo Antunes
Keyword(s):  
Systematic Review ◽  
Functional Capacity ◽  
The Elderly ◽  
Risk Of Bias ◽  
Elderly Persons ◽  
Frailty Syndrome ◽  
Exclusion Criteria ◽  
Meta Analyses ◽  
Elderly Living ◽  
Selection Of

Abstract Objective: To evaluate the association between anemia and the onset of the frailty syndrome amongst the elderly living in the community. Method: A systematic literature review of articles from the MEDLINE and LILACS databases published in English, Spanish and Portuguese over the last ten years was carried out. Articles were included in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: The search identified 193 studies. After deleting duplicated articles and applying the exclusion criteria only seven articles remained. Three articles used standardized criteria to define frailty, whereas four evaluated functional capacity as a synonym for the frailty syndrome. Conclusion: Anemia was related to a worsening of functional capacity and to the presence of the frailty syndrome in elderly persons living in the community. However, the risk of bias in the studies was high in relation to the selection of the criteria and instruments used to assess and define frailty.

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