scholarly journals Hemolysis resulting from acoustic droplet vaporization and inertial cavitation

2019 ◽  
Author(s):  
Newsha Jahanpanah ◽  
Sneha Sharma ◽  
Karla P. Mercado-Shekhar ◽  
Haili Su ◽  
Hunter A. Palcich ◽  
...  
Keyword(s):  
Acoustic Droplet Vaporization ◽  
Droplet Vaporization ◽  
Inertial Cavitation

scholarly journals Synchronized Optical and Acoustic Droplet Vaporization for Effective Sonoporation

Pharmaceutics ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 279 ◽  
Author(s):  
Wei-Wen Liu ◽  
Sy-Han Huang ◽  
Pai-Chi Li
Keyword(s):  
Laser Power ◽  
Continuous Wave ◽  
Synergistic Effects ◽  
Tumor Therapy ◽  
Average Power ◽  
Acoustic Droplet Vaporization ◽  
Droplet Vaporization ◽  
Inertial Cavitation ◽  
Cw Laser ◽  
Ultrasound Pulse

Inertial cavitation-based sonoporation has been utilized to enhance treatment delivery efficacy. In our previous study, we demonstrated that tumor therapeutic efficacy can be enhanced through vaporization-assisted sonoporation with gold nanodroplets (AuNDs). Specifically, the AuNDs were vaporized both acoustically (i.e., acoustic droplet vaporization, ADV) and optically (i.e., optical droplet vaporization, ODV). A continuous wave (CW) laser was used for ODV in combination with an ultrasound pulse for ADV. Although effective for vaporization, the use of a CW laser is not energy efficient and may create unwanted heating and concomitant tissue damage. In this study, we propose the use of a pulsed wave (PW) laser to replace the CW laser. In addition, the PW laser was applied at the rarefaction phase of the ultrasound pulse so that the synergistic effects of ADV and ODV can be expected. Therefore, a significantly lower laser average power can be expected to achieve the vaporization threshold. Compared to the CW laser power at 2 W/cm2 from the previous approach, the PW laser power was reduced to only 0.2404 W/cm2. Furthermore, we also demonstrate in vitro that the sonoporation rate was increased when the PW laser was applied at the rarefaction phase. Specifically, the vaporization signal, the inertial cavitation signal, and the sonoporation rate all displayed a 1-µs period, which corresponded to the period of the 1-MHz acoustic wave used for ADV, as a function of the relative laser delay. The increased sonoporation rate indicates that this technique has the potential to enhance sonoporation-directed drug delivery and tumor therapy with a lower laser power while keeping the cell death rate at the minimum. Photoacoustic imaging can also be performed at the same time since a PW laser is used for the ODV.

The role of inertial cavitation in acoustic droplet vaporization

2008 ◽  
Author(s):  
Mario L. Fabiilli ◽  
Kevin J. Haworth ◽  
Oliver D. Kripfgans ◽  
Paul L. Carson ◽  
J. Brian Fowlkes
Keyword(s):  
Acoustic Droplet Vaporization ◽  
Droplet Vaporization ◽  
Inertial Cavitation

scholarly journals The role of inertial cavitation in acoustic droplet vaporization

2009 ◽  
Vol 56 (5) ◽  
pp. 1006-1017 ◽  
Author(s):  
M.L. Fabiilli ◽  
K.J. Haworth ◽  
N.H. Fakhri ◽  
O.D. Kripfgans ◽  
P.L. Carson ◽  
...  
Keyword(s):  
Acoustic Droplet Vaporization ◽  
Droplet Vaporization ◽  
Inertial Cavitation

Ascertaining the relationship between acoustic droplet vaporization, inertial cavitation, and hemolysis

2019 ◽  
Vol 145 (3) ◽  
pp. 1703-1703
Author(s):  
Newsha Jahanpanah ◽  
Sneha Sharma ◽  
Karla P. Mercado-Shekhar ◽  
Haili Su ◽  
Hunter A. Palcich ◽  
...  
Keyword(s):  
Acoustic Droplet Vaporization ◽  
Droplet Vaporization ◽  
Inertial Cavitation ◽  
The Relationship
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