scholarly journals Assessment of speech impairment in patients with Parkinson's disease from acoustic quantifications of oral diadochokinetic sequences

2020 ◽  
Vol 147 (2) ◽  
pp. 839-851 ◽  
Author(s):  
Fredrik Karlsson ◽  
Ellika Schalling ◽  
Katja Laakso ◽  
Kerstin Johansson ◽  
Lena Hartelius
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Speech Impairment

scholarly journals Deficits in monitoring self-produced speech in Parkinson’s disease

2019 ◽  
Author(s):  
Henry Railo ◽  
Niklas Nokelainen ◽  
Saara Savolainen ◽  
Valtteri Kaasinen
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neural Mechanisms ◽  
Speech Impairment ◽  
Self Monitoring ◽  
Evoked Activity ◽  
And Control ◽  
N1 Wave ◽  
Electrophysiological Correlate

AbstractObjectiveSpeech deficits are common in Parkinson’s disease, and behavioural findings suggest that the deficits may be due to impaired monitoring of self-produced speech. The neural mechanisms of speech deficits are not well understood. We examined a well-documented electrophysiological correlate of speech self-monitoring in patients with Parkinson’s disease and control participants.MethodsWe measured evoked electroencephalographic responses to self-produced and passively heard sounds (/a/ phonemes) in age-matched controls (N=18), and Parkinson’s disease patients who had minor speech impairment, but reported subjectively experiencing no speech deficits (N=17).ResultsDuring speaking, auditory evoked activity 100 ms after phonation (N1 wave) was less suppressed in Parkinson’s disease than controls when compared to the activity evoked by passively heard phonemes. This difference between the groups was driven by increased amplitudes to self-produced phonemes, and reduced amplitudes passively heard phonemes in Parkinson’s disease.ConclusionsThe finding indicates that auditory evoked activity is abnormally modulated during speech in Parkinson’s patients who do not subjectively notice speech impairment. This mechanism could play a role in producing speech deficits in as the disease progresses.

Comparative analysis of speech impairment and upper limb motor dysfunction in Parkinson’s disease

2016 ◽  
Vol 124 (4) ◽  
pp. 463-470 ◽  
Author(s):  
Jan Rusz ◽  
Tereza Tykalová ◽  
Radim Krupička ◽  
Kateřina Zárubová ◽  
Michal Novotný ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Comparative Analysis ◽  
Upper Limb ◽  
Motor Dysfunction ◽  
Speech Impairment

scholarly journals Efficacy and Acceptance of a Lombard-response Device for Hypophonia in Parkinson’s Disease

2020 ◽  
Vol 47 (5) ◽  
pp. 634-641
Author(s):  
Scott Adams ◽  
Niraj Kumar ◽  
Philippe Rizek ◽  
Angeline Hong ◽  
Jenny Zhang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Low Cost ◽  
Communication Effectiveness ◽  
Conversational Speech ◽  
Trial Period ◽  
Speech Impairment ◽  
Response Device ◽  
High Satisfaction

ABSTRACT:Objective:The purpose of this study was to examine the effectiveness, satisfaction, and acceptance of a low-cost Lombard-response (LR) device in a group of individuals with Parkinson’s disease (IWPD) and their communication partners (CPs).Method:Sixteen IWPD and hypophonia and their CPs participated in the study. The IWPD wore a LR device that included a small MP3 player (Sony Walkman) and headphones playing a multi-talker noise audio file at 80 dB during lab-based speech tasks and during their daily conversational speech over a 2-week device trial period. Outcome measures included average conversational speech intensity and scores on a questionnaire related to speech impairment, communication effectiveness, and device satisfaction.Results:Conversational speech intensity of the IWPD is increased by 7 to 10 dB with the LR device. Following a 2-week trial period, eight of the IWPD (50%) gave the LR device moderate-to-high satisfaction and effectiveness ratings and decided to purchase the device for long-term daily use. At the 4-month follow-up, none of the IWPDs were still using the LR device. Device rejection was related to discomfort (loudness), headaches, interference with cognition, and difficulty controlling device.Conclusion:Short-term acceptance and satisfaction with the LR device was moderate, but long-term acceptance, beyond 4 months, was absent. Future studies are required to determine if other types of low-cost LR devices can be developed that improve long-term efficacy and device acceptance in IWPD and hypophonia.

scholarly journals Speech impairment in Parkinson’s disease: acoustic analysis of unvoiced consonants in Italian native speakers

IEEE Access ◽  
2021 ◽  
pp. 1-1
Author(s):  
Federica Amato ◽  
Luigi Borzi ◽  
Gabriella Olmo ◽  
Carlo Alberto Artusi ◽  
Gabriele Imbalzano ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Acoustic Analysis ◽  
Native Speakers ◽  
Speech Impairment

scholarly journals Discourse Analysis in Tamil Speaking Individuals with Parkinson’s Disease

2021 ◽  
Vol 6 (4) ◽  
pp. 11-16
Author(s):  
Maria J ◽  
Samyuktha N ◽  
Yuva Yoga Shree B
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Personal Narrative ◽  
Statistical Significance ◽  
Complex Structure ◽  
Speech Impairment ◽  
Motor Speech Disorder ◽  
Significant Difference ◽  
Degenerative Disorder ◽  
Age Range

Background: Parkinson’s disease (PD) is a degenerative disorder of the central nervous system. Though PD is primarily a motor speech disorder during the initial stages, as the disease progresses, a gradual decline in linguistic aspects is observed as well. The effects of disease (PD) on cognition, word retrieval, syntax, and speech/voice processes may act together to manifest uniquely in spoken language tasks. There is a dearth of studies focusing on the discourse abilities in PD, especially in Indian context. Aim: The present study aims at investigating the micro and macrostructure discourse by using personal narrative task in Tamil speaking individuals with idiopathic PD and comparing it with the neuro-typical individuals Method: Two groups comprising 5 Tamil-speaking individuals with idiopathic PD in the age range of 60–85 years and 5 neuro-typical individuals were included in the study. To assess their discourse skills, participants were engaged in a personal narrative task. The analyses done were based on macro and micro structural aspects of discourse. The raw scores were subjected to suitable statistical analysis. Results: There was a statistical significance between the Parkinson & Normal group on Total number of words, No. of Different words, No. of content words, No. of Functional words, Free morphemes, Complex structure per utterances & Relevant piece per utterance in microstructural aspects. However there was no significant difference observed in the macrostructural aspects due to smaller sample size. Conclusion: It can be concluded that in addition to speech impairment, language structure is also affected in persons with PD. Intervening at the level of discourse is an important aspect as it enhances the quality of life. Keywords: Parkinson’s disease, Discourse, Tamil speaking, Micro analysis, Macro Analysis.

scholarly journals An algorithm for Parkinson’s disease speech classification based on isolated words analysis

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Federica Amato ◽  
Luigi Borzì ◽  
Gabriella Olmo ◽  
Juan Rafael Orozco-Arroyave
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Feature Fusion ◽  
Binary Classification ◽  
Smartphone Application ◽  
Healthy Controls ◽  
Speech Impairment ◽  
Automatic Assessment ◽  
Average Value ◽  
Post Hoc

Abstract Introduction Automatic assessment of speech impairment is a cutting edge topic in Parkinson’s disease (PD). Language disorders are known to occur several years earlier than typical motor symptoms, thus speech analysis may contribute to the early diagnosis of the disease. Moreover, the remote monitoring of dysphonia could allow achieving an effective follow-up of PD clinical condition, possibly performed in the home environment. Methods In this work, we performed a multi-level analysis, progressively combining features extracted from the entire signal, the voiced segments, and the on-set/off-set regions, leading to a total number of 126 features. Furthermore, we compared the performance of early and late feature fusion schemes, aiming to identify the best model configuration and taking advantage of having 25 isolated words pronounced by each subject. We employed data from the PC-GITA database (50 healthy controls and 50 PD patients) for validation and testing. Results We implemented an optimized k-Nearest Neighbours model for the binary classification of PD patients versus healthy controls. We achieved an accuracy of 99.4% in 10-fold cross-validation and 94.3% in testing on the PC-GITA database (average value of male and female subjects). Conclusion The promising performance yielded by our model confirms the feasibility of automatic assessment of PD using voice recordings. Moreover, a post-hoc analysis of the most relevant features discloses the option of voice processing using a simple smartphone application.

scholarly journals The Impact of Parkinson's Disease on Breath Pauses and Their Relationship to Speech Impairment: A Longitudinal Study

2020 ◽  
Vol 29 (4) ◽  
pp. 1910-1922
Author(s):  
Meghan Darling-White ◽  
Jessica E. Huber
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Longitudinal Study ◽  
Matched Control ◽  
Speech Impairment ◽  
Dependent Variables ◽  
Syntactic Boundaries ◽  
The Impact ◽  
Age And Sex ◽  
Time Point

Purpose The purposes of this longitudinal study were to (a) examine the impact of Parkinson's disease (PD) progression on breath pause patterns and speech and linguistic errors and (b) determine the extent to which breath pauses and speech and linguistic errors contribute to speech impairment. Method Eight individuals with PD and eight age- and sex-matched control participants produced a reading passage on two occasions (Time 1 and Time 2) 3 years and 7 months apart on average. Two speech-language pathologists rated the severity of speech impairment for all participants at each time. Dependent variables included the location of each breath pause relative to syntax and punctuation as well as the number of disfluencies and mazes. Results At Time 1, there were no significant differences between the groups regarding breath pause patterns. At Time 2, individuals with PD produced significantly fewer breath pauses at major syntactic boundaries and periods as well as significantly more breath pauses at locations with no punctuation than control participants. Individuals with PD produced a significantly greater number of disfluencies than control participants at both time points. There were no significant differences between the groups in the number of mazes produced at either time point. Together, the number of mazes and the percentage of breath pauses at locations with no punctuation explained 50% of the variance associated with the ratings of severity of speech impairment. Conclusion These results highlight the importance of targeting both respiratory physiological and cognitive–linguistic systems in order to improve speech production in individuals with PD.

scholarly journals Progression of Self-Perceived Speech and Swallowing Impairment in Early Stage Parkinson's Disease: Longitudinal Analysis of the Unified Parkinson's Disease Rating Scale

2021 ◽  
pp. 1-13
Author(s):  
Christopher R. Watts ◽  
Yan Zhang
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rating Scale ◽  
Age At Diagnosis ◽  
Newly Diagnosed ◽  
Speech Impairment ◽  
Self Perceptions ◽  
Disease Rating ◽  
Motor Phenotype ◽  
Over Time

Purpose: The purpose of this study was to investigate the presence and progression of self-perceived speech and swallowing impairments in newly diagnosed people with Parkinson's disease (PD) longitudinally across 6 years. Method: Longitudinal data from the Parkinson's Progression Markers Initiative were analyzed across six consecutive years in a cohort of 269 newly diagnosed people with PD, and a subset of those ( n = 211) who were assessed at every time point across the 6 years. Dependent variables included self-perceived ratings of speech and swallowing impairment severity from the Unified Parkinson's Disease Rating Scale. Patient-centered factors of age at diagnosis and motor phenotype were also assessed to determine if they were related to the change in self-perceived speech and swallowing impairments. Results: Overall, self-perceived speech and swallowing impairments were present in newly diagnosed people with PD, although over time, the degree of severity for both remained in the mild range. However, the rate of change over time was significant for perceived speech impairment, F (5.5, 1158.8) = 21.1, p < .001), and perceived swallowing impairment, F (5.2, 1082.6) = 8.6, p < .001. Changes for speech and swallowing impairment were both in the direction of progressive severity. There were no effects of age at diagnosis or motor phenotype on the degree of change for either speech or swallowing. Conclusions: Self-perceptions of speech and swallowing impairment changed significantly over time in newly diagnosed people with PD (PWPD). Consistent with existing literature, self-perceptions of speech impairment were rated as more severe than those of swallowing impairment. These findings reveal that even in the early years postdiagnoses, PWPD are experiencing changes to speech and swallowing function, albeit within the mildly severe range. The presence of self-perceived mild speech and swallowing impairments in the initial years postdiagnosis may support the need for intervention to improve and or sustain function over time.

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