Real-time imaging-guided microbubble mediated high intensity focused ultrasound heating in an ex-vivo machine-perfused pig liver

2018 ◽  
Vol 144 (3) ◽  
pp. 1852-1852
Author(s):  
Dingjie Suo ◽  
Eric Juang ◽  
Sara Keller ◽  
Michael Averkiou
Keyword(s):  
Real Time ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Ex Vivo ◽  
High Intensity Focused Ultrasound ◽  
Pig Liver ◽  
Real Time Imaging

scholarly journals Characterization and Ex Vivo evaluation of an extracorporeal high‐intensity focused ultrasound (HIFU) system

2021 ◽  
Author(s):  
Yufeng Zhou ◽  
Bryan W. Cunitz ◽  
Barbrina Dunmire ◽  
Yak‐Nam Wang ◽  
Steven G. Karl ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
Ex Vivo ◽  
High Intensity Focused Ultrasound

High-Intensity Focused Ultrasound Scattering at Mammal Vertebrae

2020 ◽  
Author(s):  
David Sanford ◽  
Christoph Schaal
Keyword(s):  
High Intensity ◽  
Laboratory Experiments ◽  
Energy Deposition ◽  
Focused Ultrasound ◽  
Complex Geometry ◽  
Ex Vivo ◽  
Pulsed Laser ◽  
High Intensity Focused Ultrasound ◽  
Focal Region ◽  
Homogeneous Media

Abstract High-intensity focused ultrasound (HIFU) is used clinically to heat cells therapeutically or to destroy them through heat or cavitation. In homogeneous media, the highest wave amplitudes occur at a predictable focal region. However, HIFU is generally not used in the proximity of bones due to wave absorption and scattering. Ultrasound is passed through the skull in some clinical trials, but the complex geometry of the spine poses a greater targeting challenge and currently prohibits therapeutic ultrasound treatments near the vertebral column. This paper presents a comprehensive experimental study involving shadowgraphy and hydrophone measurements to determine the spatial distribution of pressure amplitudes from induced HIFU waves near vertebrae. First, a bone-like composite plate that is partially obstructing the induced waves is shown to break the conical HIFU form into two regions. Wave images are captured using pulsed laser shadowgraphy, and hydrophone measurements over the same region are compared to the shadowgraphy intensity plots to validate the procedure. Next, shadowgraphy is performed for an individual, clean, ex-vivo feline vertebra. The results indicate that shadowgraphy can be used to determine energy deposition patterns and to determine heating at a specific location. The latter is confirmed through additional temperature measurements. Overall, these laboratory experiments may help determine the efficacy of warming specific nerve cells within mammal vertebrae without causing damage to adjacent tissue.

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