In vivo measurements of muscle elasticity applying shear waves excited with focused ultrasound

2017 ◽  
Vol 141 (5) ◽  
pp. 3613-3613
Author(s):  
Timofey Krit ◽  
Valeriy Andreev ◽  
Igor Demin ◽  
Pavel Rykhtik ◽  
Elena Ryabova
Keyword(s):  
Focused Ultrasound ◽  
Shear Waves ◽  
Muscle Elasticity ◽  
In Vivo Measurements

Ultrasound-based Safety Assessment during Moving Organ Tracking Towards In Vivo Focused Ultrasound Therapy

2019 ◽  
Author(s):  
A Mariani ◽  
◽  
L Morchi ◽  
A Diodato ◽  
A Cafarelli ◽  
...  
Keyword(s):  
Safety Assessment ◽  
Focused Ultrasound ◽  
Ultrasound Therapy

scholarly journals Simulating a Ground Truth for Transit Time Analysis of Indicator Dilution Curves

2020 ◽  
Vol 6 (3) ◽  
pp. 268-271
Author(s):  
Michael Reiß ◽  
Ady Naber ◽  
Werner Nahm
Keyword(s):  
Transit Time ◽  
Sampling Rate ◽  
Ground Truth ◽  
Indicator Dilution ◽  
Cross Sectional ◽  
In Vivo Measurements ◽  
Multiple Indicator Dilution ◽  
Transit Times ◽  
Dilution Curves

AbstractTransit times of a bolus through an organ can provide valuable information for researchers, technicians and clinicians. Therefore, an indicator is injected and the temporal propagation is monitored at two distinct locations. The transit time extracted from two indicator dilution curves can be used to calculate for example blood flow and thus provide the surgeon with important diagnostic information. However, the performance of methods to determine the transit time Δt cannot be assessed quantitatively due to the lack of a sufficient and trustworthy ground truth derived from in vivo measurements. Therefore, we propose a method to obtain an in silico generated dataset of differently subsampled indicator dilution curves with a ground truth of the transit time. This method allows variations on shape, sampling rate and noise while being accurate and easily configurable. COMSOL Multiphysics is used to simulate a laminar flow through a pipe containing blood analogue. The indicator is modelled as a rectangular function of concentration in a segment of the pipe. Afterwards, a flow is applied and the rectangular function will be diluted. Shape varying dilution curves are obtained by discrete-time measurement of the average dye concentration over different cross-sectional areas of the pipe. One dataset is obtained by duplicating one curve followed by subsampling, delaying and applying noise. Multiple indicator dilution curves were simulated, which are qualitatively matching in vivo measurements. The curves temporal resolution, delay and noise level can be chosen according to the requirements of the field of research. Various datasets, each containing two corresponding dilution curves with an existing ground truth transit time, are now available. With additional knowledge or assumptions regarding the detection-specific transfer function, realistic signal characteristics can be simulated. The accuracy of methods for the assessment of Δt can now be quantitatively compared and their sensitivity to noise evaluated.

In vivo measurements of glenohumeral distraction technique performed in three different joint positions

2021 ◽  
pp. 1-7
Author(s):  
Diego Guerra-Rodríguez ◽  
Liliana Rozo ◽  
Daniel Basilio ◽  
Juan Guerrero-Henriquez
Keyword(s):  
In Vivo Measurements

scholarly journals Single-cell mapping of focused ultrasound-transfected brain

Gene Therapy ◽  
2021 ◽  
Author(s):  
A. S. Mathew ◽  
C. M. Gorick ◽  
R. J. Price
Keyword(s):  
Single Cell ◽  
Focused Ultrasound ◽  
Cell Types ◽  
Brain Cell ◽  
Therapeutic Modality ◽  
Full Potential ◽  
Stress Genes ◽  
Multiple Cell ◽  
Differential Gene

AbstractGene delivery via focused ultrasound (FUS) mediated blood-brain barrier (BBB) opening is a disruptive therapeutic modality. Unlocking its full potential will require an understanding of how FUS parameters (e.g., peak-negative pressure (PNP)) affect transfected cell populations. Following plasmid (mRuby) delivery across the BBB with 1 MHz FUS, we used single-cell RNA-sequencing to ascertain that distributions of transfected cell types were highly dependent on PNP. Cells of the BBB (i.e., endothelial cells, pericytes, and astrocytes) were enriched at 0.2 MPa PNP, while transfection of cells distal to the BBB (i.e., neurons, oligodendrocytes, and microglia) was augmented at 0.4 MPa PNP. PNP-dependent differential gene expression was observed for multiple cell types. Cell stress genes were upregulated proportional to PNP, independent of cell type. Our results underscore how FUS may be tuned to bias transfection toward specific brain cell types in vivo and predict how those cells will respond to transfection.

scholarly journals Thalamic Connectivity in Patients with Essential Tremor Treated with MR Imaging–guided Focused Ultrasound: In Vivo Fiber Tracking by Using Diffusion-Tensor MR Imaging

Radiology ◽  
2014 ◽  
Vol 272 (1) ◽  
pp. 202-209 ◽  
Author(s):  
Max Wintermark ◽  
Diane S. Huss ◽  
Binit B. Shah ◽  
Nicholas Tustison ◽  
T. Jason Druzgal ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Essential Tremor ◽  
Focused Ultrasound ◽  
Diffusion Tensor ◽  
Fiber Tracking ◽  
Diffusion Tensor Mr Imaging
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