Healing and the immune response following boiling histotripsy ablation of renal carcinoma in the Eker rat

2016 ◽  
Vol 140 (4) ◽  
pp. 3083-3083
Author(s):  
George R. Schade ◽  
Yak-Nam Wang ◽  
Kayla Gravelle ◽  
Stella Whang ◽  
Venu Pillarisetty ◽  
...  
Keyword(s):  
Immune Response ◽  
Renal Carcinoma ◽  
Eker Rat

scholarly journals MP39-14 BOILING HISTOTRIPSY ABLATION OF IN VIVO RENAL CARCINOMA IN THE EKER RAT

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
George R. Schade ◽  
Yak-Nam Wang ◽  
Samantha D'Andrea ◽  
Joo Ha Hwang ◽  
Daniel W. Lin ◽  
...  
Keyword(s):  
Renal Carcinoma ◽  
Eker Rat

scholarly journals Evaluation of the Systemic Response to Boiling Histotripsy Treatment for Renal Carcinoma

2018 ◽  
Author(s):  
George R. Schade
Keyword(s):  
Immune Response ◽  
Renal Carcinoma ◽  
Local Treatment ◽  
Treatment Strategies ◽  
Renal Tumors ◽  
Yield Potential ◽  
Invasive Treatment ◽  
Contralateral Kidney

More efficacious and less invasive treatment strategies are needed for renal carcinoma (RCC). One promising approach is the focused ultrasound (FUS) technique known as boiling histotripsy (BH). BH is capable of mechanically destroying renal tumors in vivo with negligible thermal effects. BH ablation of RCC has been associated with release of endogenous danger signals, altered cytokine milieu and inflammatory infiltrate shortly after treatment indicative of an immune response. Because immunotherapy remains the only therapy capable of inducing long-term disease remission in ~5% of patients with metastatic disease, we hypothesize that the systemic immune response triggered by BH may provide additional therapeutic benefit beyond the local treatment. This hypothesis will be tested in two aims: 1) determine if BH ablation of RCC stimulates a systemic anti-tumor immune response and 2) evaluate the long-term oncologic effects of BH ablation of RCC. We propose to treat RCC in the Eker rat with extracorporeal BH or sham FUS procedures. We will then characterize the immune response following BH vs. SHAM treatments and the oncologic impact of BH vs. SHAM treatment on both the targeted tumor, as well as non-treated tumors in both the ipsilateral and contralateral kidney. We believe the proposed study will demonstrate that BH treatment of RCC will stimulate an anti-tumor immune response and yield potential targets to improve this response. Ultimately, we hypothesize that this approach could improve outcomes of focal therapy and could lead to a clinically actionable combination FUS immunotherapy to improve response rates and outcomes for metastatic RCC

Suppression of the Neoplastic Phenotype by Replacement of theTsc2Gene in Eker Rat Renal Carcinoma Cells

1996 ◽  
Vol 219 (1) ◽  
pp. 70-75 ◽  
Author(s):  
Kenji Orimoto ◽  
Haruo Tsuchiya ◽  
Toshiyuki Kobayashi ◽  
Tamotsu Matsuda ◽  
Okio Hino
Keyword(s):  
Renal Carcinoma ◽  
Carcinoma Cells ◽  
Neoplastic Phenotype ◽  
Eker Rat ◽  
Renal Carcinoma Cells

scholarly journals Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene.

1994 ◽  
Vol 91 (24) ◽  
pp. 11413-11416 ◽  
Author(s):  
R. S. Yeung ◽  
G. H. Xiao ◽  
F. Jin ◽  
W. C. Lee ◽  
J. R. Testa ◽  
...  
Keyword(s):  
Tuberous Sclerosis ◽  
Renal Carcinoma ◽  
Germ Line ◽  
Tsc2 Gene ◽  
Eker Rat ◽  
Germ Line Mutation

Humoral and cellular immune response to a crude exo-antigen and purified keratinase of Microsporum canis in experimentally infected guinea pigs

1999 ◽  
Vol 37 (2) ◽  
pp. 123-129 ◽  
Author(s):  
B. R. Mignon ◽  
T. Leclipteux ◽  
CH. Focant ◽  
A. J. Nikkels ◽  
G. E. PIErard ◽  
...  
Keyword(s):  
Immune Response ◽  
Cellular Immune Response ◽  
Guinea Pigs ◽  
Microsporum Canis ◽  
Cellular Immune

1248: Impact of Surgical Treatment of Renal Carcinoma on Renal Function and Blood Pressure: A Race- and Age-Dependent Association

2007 ◽  
Vol 177 (4S) ◽  
pp. 411-412
Author(s):  
Javier Miller ◽  
Angela Smith ◽  
Kris Gunn ◽  
Erik Kouba ◽  
Eric M. Wallen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Surgical Treatment ◽  
Renal Carcinoma ◽  
Age Dependent

1651: Molecular Prognostic Modeling Using Protein Expression Profile in Clear Cell Renal Carcinoma

2004 ◽  
Vol 171 (4S) ◽  
pp. 436-436 ◽  
Author(s):  
Hyung L. Kim ◽  
David B. Seligson ◽  
Nicolette Janzen ◽  
Matthew H. Bui ◽  
Robert A. Figlin ◽  
...  
Keyword(s):  
Protein Expression ◽  
Expression Profile ◽  
Renal Carcinoma ◽  
Clear Cell ◽  
Clear Cell Renal Carcinoma ◽  
Protein Expression Profile ◽  
Cell Renal Carcinoma ◽  
Prognostic Modeling

Abstract #418: Effect of Testosterone (T) Replacement with a T-Gel or a New Oral T Formulation (Rextoro) on Selected Biomarkers of Endothelial Injury and Immune Response to Lipids

2015 ◽  
Vol 21 ◽  
pp. 93
Author(s):  
Merrell Magelli ◽  
Ronald Swerdloff ◽  
John Amory ◽  
Gregory Flippo ◽  
Wael Salameh ◽  
...  
Keyword(s):  
Immune Response ◽  
Endothelial Injury
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