A portable transcranial focused ultrasound system for non-invasive applications in small animals

2016 ◽  
Vol 140 (4) ◽  
pp. 2984-2984
Author(s):  
Pavlos Anastasiadis ◽  
Ben Nguyen ◽  
David S. Hersh ◽  
Sijia Guo ◽  
Rao Gullapalli ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Small Animals ◽  
Non Invasive ◽  
Ultrasound System ◽  
Transcranial Focused Ultrasound

Implication of Auditory Confounding in Interpreting Somatosensory and Motor Responses in Low-Intensity Transcranial Focused Ultrasound Stimulation

2021 ◽  
Author(s):  
Christine Park ◽  
Mengyue Chen ◽  
Taewon Kim
Keyword(s):  
Focused Ultrasound ◽  
Auditory Pathway ◽  
Localization Accuracy ◽  
Motor Responses ◽  
Non Invasive ◽  
Low Intensity ◽  
Ultrasound Stimulation ◽  
Transcranial Focused Ultrasound ◽  
Indirect Stimulation ◽  
Stimulation Of

Low-intensity transcranial focused ultrasound (LI-tFUS) stimulation is a non-invasive neuromodulation tool that demonstrates high target localization accuracy and depth penetration. It has been shown to modulate activities in the primary motor and somatosensory cortex. Previous studies in animals and humans acknowledged the possibility of indirect stimulation of the peripheral auditory pathway that could confound the somatosensory and motor responses observed with LI-tFUS stimulation. Here, we discuss the implications and interpretations of auditory confounding in the context of neuromodulation.

scholarly journals Investigation of the Therapeutic Effect of Doxorubicin Combined With Focused Shockwave on Glioblastoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Wei-Hao Liao ◽  
Ming-Yen Hsiao ◽  
Yi Kung ◽  
Abel Po-Hao Huang ◽  
Wen-Shiang Chen
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen Species Production ◽  
Focused Ultrasound ◽  
Oxygen Species ◽  
Heating Effect ◽  
Rat Models ◽  
Non Invasive ◽  
Therapeutic Drugs ◽  
Species Production ◽  
Transcranial Focused Ultrasound

BackgroundGlioblastoma multiforme (GBM) is currently the most devastating brain tumor globally and produces a high mortality rate. GBM is also challenging to eradicate using surgery due to its invasive characteristics. Moreover, the blood-brain barrier (BBB) increases the difficulty of transporting most therapeutic drugs to tumor sites. The use of transcranial focused ultrasound (FUS) has recently been investigated for opening the BBB to facilitate drug delivery. A special form of FUS, the shockwave (SW), has also been shown to open BBB efficiently. SW has several advantages including no heating effect, less reactive oxygen species production, good transcranial ability, and no need to supply microbubbles.MethodsWe employed a commercial SW device, which is a common tool used for musculoskeletal disorders, to improve doxorubicin delivery across the BBB and evaluated its therapeutic efficacy on GBM rat models. SW emits relatively short but stronger mechanical pulses comparing with FUS.ResultsThe results demonstrated that doxorubicin combined with SW treatment substantially inhibited tumor growth and prolonged overall survival.ConclusionsThe present study shows the non-invasive transcranial SW may have potential for the treatment of GBM in future clinical setting.

FUS-mediated Neuromodulation from Unanesthetized Freely-moving Animals

2018 ◽  
Author(s):  
Wonhye Lee ◽  
Seung-Schik Yoo
Keyword(s):  
Success Rate ◽  
Safety Profile ◽  
Focused Ultrasound ◽  
Behavioral Responses ◽  
Small Animals ◽  
Electrophysiological Signals ◽  
Freely Moving ◽  
Behavioral Monitoring ◽  
Transcranial Focused Ultrasound ◽  
Immunohistological Analysis

The goal of the proposed research is to implement and apply non-thermal transcranial focused ultrasound (FUS) to the somatomotor area (SM1) of unanesthetized, freely- moving, awake small animals (rats). We will examine the neuromodulatory outcome based on electrophysiological signals and motor behavioral responses to the sonication. The safety profile of the sonication will also be evaluated through immunohistological analysis and behavioral monitoring. The investigation of FUS neuromodulatory effects in awake animals will be essential for assessing the success rate and reproducibility of stimulation, without the confounding effects of anesthesia.

scholarly journals Transcranial Focused Ultrasound Neuromodulation: A Review of the Excitatory and Inhibitory Effects on Brain Activity in Human and Animals

2021 ◽  
Vol 15 ◽  
Author(s):  
Tingting Zhang ◽  
Na Pan ◽  
Yuping Wang ◽  
Chunyan Liu ◽  
Shimin Hu
Keyword(s):  
Focused Ultrasound ◽  
Brain Activity ◽  
Pressure Effects ◽  
Spinal Reflexes ◽  
Brain Diseases ◽  
Inhibitory Effects ◽  
Mechanical Pressure ◽  
Non Invasive ◽  
Non Destructive ◽  
Transcranial Focused Ultrasound

Non-invasive neuromodulation technology is important for the treatment of brain diseases. The effects of focused ultrasound on neuronal activity have been investigated since the 1920s. Low intensity transcranial focused ultrasound (tFUS) can exert non-destructive mechanical pressure effects on cellular membranes and ion channels and has been shown to modulate the activity of peripheral nerves, spinal reflexes, the cortex, and even deep brain nuclei, such as the thalamus. It has obvious advantages in terms of security and spatial selectivity. This technology is considered to have broad application prospects in the treatment of neurodegenerative disorders and neuropsychiatric disorders. This review synthesizes animal and human research outcomes and offers an integrated description of the excitatory and inhibitory effects of tFUS in varying experimental and disease conditions.

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