Transcranial thermal ablation with a 230 kHz MRI-guided focused ultrasound system in a large animal mode

2016 ◽  
Vol 139 (4) ◽  
pp. 2116-2116
Author(s):  
Nathan McDannold ◽  
Jonathan Sutton ◽  
Natalia Vykhodtseva ◽  
Margaret Livingstone
Keyword(s):  
Thermal Ablation ◽  
Focused Ultrasound ◽  
Large Animal ◽  
Ultrasound System ◽  
Mri Guided

A software platform controlling an MRI guided focused ultrasound system

2012 ◽  
Author(s):  
Christos Yiallouras ◽  
Ioakim Marinos ◽  
Alexandrou Alexis ◽  
Venediktos Hadji Savvas ◽  
Nicos Milonas ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Software Platform ◽  
Ultrasound System ◽  
Mri Guided

Design, characterization, and performance of a dual aperture, focused ultrasound system for microbubble-mediated, non-thermal ablation in rat brain

2015 ◽  
Vol 138 (3) ◽  
pp. 1821-1821
Author(s):  
Jonathan Sutton ◽  
Yui Power ◽  
Yongzhi Zhang ◽  
Natalia Vykhodtseva ◽  
Nathan McDannold
Keyword(s):  
Rat Brain ◽  
Thermal Ablation ◽  
Focused Ultrasound ◽  
Ultrasound System ◽  
And Performance

scholarly journals Intracranial inertial cavitation threshold and thermal ablation lesion creation using MRI-guided 220-kHz focused ultrasound surgery: preclinical investigation

2015 ◽  
Vol 122 (1) ◽  
pp. 152-161 ◽  
Author(s):  
Zhiyuan Xu ◽  
Carissa Carlson ◽  
John Snell ◽  
Matt Eames ◽  
Arik Hananel ◽  
...  
Keyword(s):  
Low Power ◽  
Thermal Ablation ◽  
Focused Ultrasound ◽  
Acoustic Energy ◽  
Thermal Lesion ◽  
Ischemic Infarction ◽  
Inertial Cavitation ◽  
Long Duration ◽  
Mri Guided ◽  
Cavitation Activity

OBJECT In biological tissues, it is known that the creation of gas bubbles (cavitation) during ultrasound exposure is more likely to occur at lower rather than higher frequencies. Upon collapsing, such bubbles can induce hemorrhage. Thus, acoustic inertial cavitation secondary to a 220-kHz MRI-guided focused ultrasound (MRgFUS) surgery is a serious safety issue, and animal studies are mandatory for laying the groundwork for the use of low-frequency systems in future clinical trials. The authors investigate here the in vivo potential thresholds of MRgFUS-induced inertial cavitation and MRgFUS-induced thermal coagulation using MRI, acoustic spectroscopy, and histology. METHODS Ten female piglets that had undergone a craniectomy were sonicated using a 220-kHz transcranial MRgFUS system over an acoustic energy range of 5600–14,000 J. For each piglet, a long-duration sonication (40-second duration) was performed on the right thalamus, and a short sonication (20-second duration) was performed on the left thalamus. An acoustic power range of 140–300 W was used for long-duration sonications and 300–700 W for short-duration sonications. Signals collected by 2 passive cavitation detectors were stored in memory during each sonication, and any subsequent cavitation activity was integrated within the bandwidth of the detectors. Real-time 2D MR thermometry was performed during the sonications. T1-weighted, T2-weighted, gradient-recalled echo, and diffusion-weighted imaging MRI was performed after treatment to assess the lesions. The piglets were killed immediately after the last series of posttreatment MR images were obtained. Their brains were harvested, and histological examinations were then performed to further evaluate the lesions. RESULTS Two types of lesions were induced: thermal ablation lesions, as evidenced by an acute ischemic infarction on MRI and histology, and hemorrhagic lesions, associated with inertial cavitation. Passive cavitation signals exhibited 3 main patterns identified as follows: no cavitation, stable cavitation, and inertial cavitation. Low-power and longer sonications induced only thermal lesions, with a peak temperature threshold for lesioning of 53°C. Hemorrhagic lesions occurred only with high-power and shorter sonications. The sizes of the hemorrhages measured on macroscopic histological examinations correlated with the intensity of the cavitation activity (R2 = 0.74). The acoustic cavitation activity detected by the passive cavitation detectors exhibited a threshold of 0.09 V·Hz for the occurrence of hemorrhages. CONCLUSIONS This work demonstrates that 220-kHz ultrasound is capable of inducing a thermal lesion in the brain of living swines without hemorrhage. Although the same acoustic energy can induce either a hemorrhage or a thermal lesion, it seems that low-power, long-duration sonication is less likely to cause hemorrhage and may be safer. Although further study is needed to decrease the likelihood of ischemic infarction associated with the 220-kHz ultrasound, the threshold established in this work may allow for the detection and prevention of deleterious cavitations.

scholarly journals First clinical experience with a dedicated MRI-guided high-intensity focused ultrasound system for breast cancer ablation

2016 ◽  
Vol 26 (11) ◽  
pp. 4037-4046 ◽  
Author(s):  
Laura G. Merckel ◽  
Floor M. Knuttel ◽  
Roel Deckers ◽  
Thijs van Dalen ◽  
Gerald Schubert ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Experience ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound System ◽  
Mri Guided ◽  
Cancer Ablation ◽  
Dedicated Mri

The targeting accuracy of a preclinical MRI-guided focused ultrasound system

2014 ◽  
Vol 42 (1) ◽  
pp. 430-439 ◽  
Author(s):  
N. P. K. Ellens ◽  
I. Kobelevskiy ◽  
A. Chau ◽  
A. C. Waspe ◽  
R. M. Staruch ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Ultrasound System ◽  
Mri Guided ◽  
Preclinical Mri ◽  
Targeting Accuracy

scholarly journals MRI-guided coupling for a focused ultrasound system using a top-to-bottom propagation

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Marinos Yiannakou ◽  
George Menikou ◽  
Christos Yiallouras ◽  
Christakis Damianou
Keyword(s):  
Focused Ultrasound ◽  
Ultrasound System ◽  
Mri Guided

scholarly journals MRI-based thermal dosimetry and diffusion-weighted imaging of MRI-guided focused ultrasound thermal ablation of uterine fibroids

2009 ◽  
Vol 29 (2) ◽  
pp. 404-411 ◽  
Author(s):  
Magdalini C. Pilatou ◽  
Elizabeth A. Stewart ◽  
Stephan E. Maier ◽  
Fiona M. Fennessy ◽  
Kullervo Hynynen ◽  
...  
Keyword(s):  
Thermal Ablation ◽  
Diffusion Weighted Imaging ◽  
Focused Ultrasound ◽  
Uterine Fibroids ◽  
Diffusion Weighted ◽  
Mri Guided ◽  
And Diffusion
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