Modeling dynamic properties of spontaneous otoacoustic emissions: Low-frequency biasing and entrainment

2016 ◽  
Vol 139 (4) ◽  
pp. 2074-2075
Author(s):  
Dario Vignali ◽  
Stephen J. Elliott ◽  
Ben Lineton
Keyword(s):  
Otoacoustic Emissions ◽  
Dynamic Properties ◽  
Low Frequency ◽  
Spontaneous Otoacoustic Emissions

scholarly journals Low-frequency sound affects active micromechanics in the human inner ear

2014 ◽  
Vol 1 (2) ◽  
pp. 140166 ◽  
Author(s):  
Kathrin Kugler ◽  
Lutz Wiegrebe ◽  
Benedikt Grothe ◽  
Manfred Kössl ◽  
Robert Gürkov ◽  
...  
Keyword(s):  
Inner Ear ◽  
Hair Cells ◽  
Otoacoustic Emissions ◽  
Low Frequency ◽  
Short Exposure ◽  
Low Frequencies ◽  
Spontaneous Otoacoustic Emissions ◽  
Human Cochlea ◽  
Human Hearing ◽  
The Impact

Noise-induced hearing loss is one of the most common auditory pathologies, resulting from overstimulation of the human cochlea, an exquisitely sensitive micromechanical device. At very low frequencies (less than 250 Hz), however, the sensitivity of human hearing, and therefore the perceived loudness is poor. The perceived loudness is mediated by the inner hair cells of the cochlea which are driven very inadequately at low frequencies. To assess the impact of low-frequency (LF) sound, we exploited a by-product of the active amplification of sound outer hair cells (OHCs) perform, so-called spontaneous otoacoustic emissions. These are faint sounds produced by the inner ear that can be used to detect changes of cochlear physiology. We show that a short exposure to perceptually unobtrusive, LF sounds significantly affects OHCs: a 90 s, 80 dB(A) LF sound induced slow, concordant and positively correlated frequency and level oscillations of spontaneous otoacoustic emissions that lasted for about 2 min after LF sound offset. LF sounds, contrary to their unobtrusive perception, strongly stimulate the human cochlea and affect amplification processes in the most sensitive and important frequency range of human hearing.

scholarly journals Spontaneous Otoacoustic Emissions Reveal an Efficient Auditory Efferent Network

2018 ◽  
Vol 61 (11) ◽  
pp. 2827-2832 ◽  
Author(s):  
Viorica Marian ◽  
Tuan Q. Lam ◽  
Sayuri Hayakawa ◽  
Sumitrajit Dhar
Keyword(s):  
Otoacoustic Emissions ◽  
Spontaneous Otoacoustic Emissions ◽  
Auditory Efferent

scholarly journals Dynamics and Protein–Solvent Interactions of Hemoglobin in T and R Quaternary Conformation

2002 ◽  
Vol 16 (3-4) ◽  
pp. 227-233 ◽  
Author(s):  
Chiara Caronna ◽  
Antonio Cupane
Keyword(s):  
Quaternary Structure ◽  
Dynamic Properties ◽  
Low Frequency ◽  
Helical Structure ◽  
Blue Shift ◽  
Peak Frequency ◽  
The Other ◽  
Solvent Interactions ◽  
Reported Data ◽  
Increasing Temperature

In this work we report the thermal behaviour of the amide I′ band of carbonmonoxy and deoxy hemoglobin in 65% v/v glycerolD8/D2O solutions and in the temperature interval 10–295 K. Following recent suggestions in the literature, we analyze the amide I′ band in terms of two components, one at about 1630 cm−1and the other at about 1650 cm−1, that are assigned to solvent‒exposed and buried α‒helical regions, respectively.For deoxy hemoglobin (in T quaternary structure) both components are narrower with respect to carbonmonoxy hemoglobin (in R quaternary structure), while the peak frequency blue shift observed, upon increasing temperature, for the component at about 1630 cm−1is smaller. The reported data provide evidence of the dependence of hemoglobin dynamic properties upon the protein quaternary structure and suggest a more compact α‒helical structure of hemoglobin in T conformation, with reduced population of low‒frequency modes involving the solvent and protein.

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