A follow up low frequency propagation experiment in Currituck Sound

2015 ◽  
Vol 137 (4) ◽  
pp. 2439-2439
Author(s):  
Richard D. Costley ◽  
Andrew R. McNeese ◽  
Megan S. Ballard ◽  
Kevin M. Lee ◽  
Kent K. Hathaway ◽  
...  
Keyword(s):  
Low Frequency ◽  
Currituck Sound ◽  
Propagation Experiment

Prognostic relevance of anamnestic and diagnostic parameters in low-frequency hearing impairment

2006 ◽  
Vol 120 (8) ◽  
pp. 613-618 ◽  
Author(s):  
W Maier ◽  
J Schipper
Keyword(s):  
Prognostic Factor ◽  
Hearing Impairment ◽  
Hearing Threshold ◽  
Low Frequency ◽  
Prognostic Indicators ◽  
Infusion Therapy ◽  
Prognostic Relevance ◽  
Long Time ◽  
Dehydration Therapy

Low-frequency hearing impairment (LFHI) is mainly attributed to endolymphatic hydrops and has a great variety of possible outcomes. At present, no conservative therapeutic regimen has proven to be ‘gold-standard’, and information about the prognostic indicators of LFHI is scarce.In a retrospective investigation, we evaluated the records of 90 patients who had been treated with infusions improving blood perfusion. In patients lacking complete remission, dehydration infusion therapy was added. We also undertook audiometric follow up. We calculated the outcomes after infusion therapy, dehydration therapy and after long-time hearing follow up, and we determined the prognostic relevance of several parameters of anamnesis and clinical examination to outcomes, for both therapeutic interventions and long-time hearing.The prognosis of LFHI was significantly correlated to certain anamnestic and clinical parameters; a short duration of the disease, lack of vertigo and female gender implied a better outcome. The pretherapeutic hearing threshold was an important prognostic factor; the outcome was significantly worse in patients with distinct hearing impairment in low or high frequencies, compared with that in patients with little hearing loss. Whereas vertigo was a negative prognostic factor, the results of quantitative vestibular testing were irrelevant to the outcome. The glycerol test failed to predict the effectiveness of dehydration therapy and lacked any value in predicting prognosis.These results allow the clinician to focus the anamnesis and diagnostic examination on prognostically relevant parameters, thus enabling a better estimation of the long-term disease course and improved counselling of patients. Furthermore, these results help to distinguish valuable from irrelevant diagnostic procedures.

scholarly journals Non-contact radiofrequency-induced reduction of subcutaneous abdominal fat correlates with initial cardiovascular autonomic balance and fat tissue hormones: safety analysis

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 49 ◽  
Author(s):  
Jiri Pumprla ◽  
Kinga Howorka ◽  
Zuzana Kolackova ◽  
Eliska Sovova
Keyword(s):  
Autonomic Function ◽  
Spectral Power ◽  
Low Frequency ◽  
Abdominal Fat ◽  
Autonomic Response ◽  
Abdominal Circumference ◽  
Autonomic Balance ◽  
Fat Tissue ◽  
Tissue Heating

Background and objective: The non-invasive reduction of subcutaneous abdominal fat became popular in the last decade. Radiofrequency (RF), non-contact, selective-field device Vanquish® has been developed to selectively induce deep fat tissue heating to reduce waist circumference. Our analysis evaluates immediate and sustained effects of this treatment on cardiovascular autonomic function and on selected metabolic parameters.Study design/patients and methods: A retrospective proof-of-concept analysis of RF treatment effects was conducted in 20 individuals with metabolic syndrome, to reduce the subcutaneous abdominal fat. Four 30-minutes treatment sessions (manufacturer´s standard protocol) were performed in 1-week intervals. Vital signs, ECG, lab screening, body composition, subcutaneous fat thickness and spectral analysis of heart rate variability (HRV) have been examined before, after the 1st and 4th treatment, and at follow-up visits 1 month and 3 months after the treatment.Results: The RF treatment led to a significant reduction of abdominal circumference after the 4th session (p<0.001), and during follow-up after 1 and 3 months (p<0.001 and p<0.02, resp.). There was a significant correlation (r=-0.58, p=0.007) between reduction of abdominal circumference and initial very-low frequency (VLF) spectral power at 1 month follow-up. A significant increase of cumulative spectral power in low frequency (p=0.02) and reduction in high frequency (p=0.05) band have been observed immediately (20+14 minutes) after the treatment. On the contrary, no sustained impact on autonomic balance has been recorded 39+18 days after the treatment. A significant correlation between the initial adiponectin values and immediate autonomic response to one treatment was observed in VLF and total spectral bands (r>0.59, p<0.04).Conclusions: Our analysis shows that the selective-field RF treatment is safe and efficient for reduction of subcutaneous abdominal fat. While the treatment increases the immediate sympathetic response of the body to deep tissue heating, no sustained change in autonomic function could be recorded at 1 month follow-up. The observed correlation between initial VLF spectral power and waist circumference reduction at follow-up, as well as the association of initial adiponectin values and immediate autonomic response to the treatment might be instrumental for decisions on body contouring strategies.

scholarly journals LOFAR 144-MHz follow-up observations of GW170817

2020 ◽  
Vol 494 (4) ◽  
pp. 5110-5117
Author(s):  
J W Broderick ◽  
T W Shimwell ◽  
K Gourdji ◽  
A Rowlinson ◽  
S Nissanke ◽  
...  
Keyword(s):  
Neutron Star ◽  
Low Frequency ◽  
Radio Spectrum ◽  
Central Frequency ◽  
Binary Neutron Star ◽  
Upper Limit ◽  
Upper Limits ◽  
Maximum Elevation ◽  
Merger Event

ABSTRACT We present low-radio-frequency follow-up observations of AT 2017gfo, the electromagnetic counterpart of GW170817, which was the first binary neutron star merger to be detected by Advanced LIGO–Virgo. These data, with a central frequency of 144 MHz, were obtained with LOFAR, the Low-Frequency Array. The maximum elevation of the target is just 13${_{.}^{\circ}}$7 when observed with LOFAR, making our observations particularly challenging to calibrate and significantly limiting the achievable sensitivity. On time-scales of 130–138 and 371–374 d after the merger event, we obtain 3σ upper limits for the afterglow component of 6.6 and 19.5 mJy beam−1, respectively. Using our best upper limit and previously published, contemporaneous higher frequency radio data, we place a limit on any potential steepening of the radio spectrum between 610 and 144 MHz: the two-point spectral index $\alpha ^{610}_{144} \gtrsim$ −2.5. We also show that LOFAR can detect the afterglows of future binary neutron star merger events occurring at more favourable elevations.

scholarly journals Preservation of residual hearing after cochlear implant surgery with slim modiolar electrode

2019 ◽  
Vol 277 (2) ◽  
pp. 367-375 ◽  
Author(s):  
Matti Iso-Mustajärvi ◽  
Sini Sipari ◽  
Heikki Löppönen ◽  
Aarno Dietz
Keyword(s):  
Low Frequency ◽  
Hearing Preservation ◽  
Acoustic Stimulation ◽  
Residual Hearing ◽  
Insertion Depth ◽  
Cochlear Implant Surgery ◽  
Computed Tomography Scans ◽  
Electric Acoustic Stimulation ◽  
Speech Recognition In Noise

Abstract Purpose To evaluate the insertion results and hearing preservation of a novel slim modiolar electrode (SME) in patients with residual hearing. Methods We retrospectively collected the data from the medical files of 17 patients (18 ears) implanted with a SME. All patients had functional low frequency hearing (PTA (0.125–0.5 kHz) ≤ 80 dB HL). The insertion results were re-examined from the postoperative cone-beam computed tomography scans. Postoperative thresholds were obtained at the time of switch-on of the sound processors (mean 43 days) and at latest follow-up (mean 582 days). The speech recognition in noise was measured with the Finnish matrix sentence test preoperatively and at follow-up. Results The mean insertion depth angle (IDA) was 395°. Neither scala dislocations nor tip fold over were detected. There were no total hearing losses. Functional low-frequency hearing was preserved in 15/18 (83%) ears at switch-on and in 14/17 (82%) ears at follow-up. According to HEARRING classification, 55% (10/18) had complete HP at switch-on and 41% (7/17) still at follow-up. Thirteen patients (14 ears) were initially fitted with electric–acoustic stimulation and seven patients (8 ears) continued to use it after follow-up. Conclusions The preliminary hearing preservation results with the SME were more favorable than reported for other perimodiolar electrodes. The results show that the array may also be feasible for electro-acoustic stimulation; it is beneficial in that it provides adequate cochlear coverage for pure electrical stimulation in the event of postoperative or progressive hearing loss.

Experience with breast cancer in a single oncology clinic in Nairobi

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 10714-10714
Author(s):  
N. A. Othieno-Abinya ◽  
H. O. Abwao ◽  
P. Bird ◽  
R. Baraza ◽  
B. Byakika ◽  
...  
Keyword(s):  
Breast Cancer ◽  
African American Women ◽  
Ductal Carcinoma ◽  
Low Frequency ◽  
Her2 Expression ◽  
Adjuvant Setting ◽  
Her2 Positive ◽  
Metastatic Setting ◽  
Age Range

10714 Background: Combinations of anthracyclines and cyclophosphamide ± 5-FU are widely used in treatment of breast cancer (BC) in the adjuvant setting. Addition of taxanes is beneficial. For Her2-positive tumours addition of herceptin may improve relapse-free survival in the adjuvant setting, and prolongs survival in metastatic setting. We routinely use doxorubicin and cyclophosphamide (AC) x 6 courses for standard risk disease and give the same x 4 followed by docetaxel ± herceptin x 4 for those with ≥ 10 positive axillary nodes. We also use AC as first line for endocrine nonresponsive metastatic BC. Methods: A total of 173 BC patients seen in our clinic between January 1997 and May 2005, 83 were given chemotherapy both in the adjuvant and metastatic settings. Results: Of 83 patients, 81 were female and 2 males, age range 24–71, median 45 years. Seventy-eight cases were ductal carcinoma, not otherwise stated, 1 colloid, 1 anaplastic, 1 adenosarcomatoid, 2 medullary. Fifty-six were post resection and 27 metastatic. Thirty eight sites of metastasis or spread were evaluable. These were skeletal 10 (26.3%), liver 7 (18.4%), chest wall 6 (15.9%), lungs and pleura 9 (23.7%), brain 4 (10.5%) and supraclavicular nodes 2 (5.3%). Her2 expression by immunohistochemistry in 20 cases was - 3+ in 7 (35%), 2+ in 3 (15%) and ≤ 1+ in 10 (50%). Out of 40 cases, 15 (37.5%) were endocrine responsive, 17 (42.5%) nonresponsive and 8 (20%) indeterminate. Twenty seven patients treated before January 2004 were recorded dead after survival ranging between 8 and 96 months, median 36 months. Only 3 patients with resected BC were recorded dead as opposed to 24 with MBC at diagnosis. Two of the deaths in the adjuvant setting were in patients with ≥ 10 nodes positive and both had the brain as the only site of metastasis. There was no significant correlation between nodal status and follow-up duration (P = 0.43), hormone receptor status and survival (P = 0.20), and Her2-expression and survival (P = 0.23). Conclusions: This material shows a low frequency of ER positivity and higher mortality particularly from brain metastasis than most Western series. It does however show a similarity to recent reports of breast cancer in African-American women. No significant financial relationships to disclose.

DNA damage and repair (DDR) gene variants and outcomes in localized and metastatic prostate cancer (mPC).

2018 ◽  
Vol 36 (6_suppl) ◽  
pp. 304-304
Author(s):  
Brandon David Bernard ◽  
Kathryn P. Gray ◽  
Grace Shaw ◽  
Laura E MacConaill ◽  
Carolyn Evan ◽  
...  
Keyword(s):  
Cox Regression ◽  
Low Frequency ◽  
Gene Variants ◽  
Castration Resistance ◽  
Dna Damage And Repair ◽  
Free Survival ◽  
Targeted Next Generation Sequencing ◽  
Death Time ◽  
Psa Relapse

304 Background: Moderate frequencies of DDR gene variants exist in mPC. Their prognostic role in localized and mPC is unclear. This study aims to characterize DDR variants in a cohort of hormone sensitive localized and mPC and assess for association with outcome. Methods: A retrospective cohort of men with PC and ≥ 2 follow up visits at DFCI and targeted next generation sequencing of prostate or metastatic tissue was identified. Biomarker (BM) positive was defined as pathogenic changes in the following DDR genes: ATM BAP1 BRCA1 BRCA2 BRIP1 CHEK2 MSH2 MSH6 PALB2 PMS2. For localized PC, outcome endpoints included event-free survival (EFS) (time from prostate biopsy to PSA relapse/metastasis/death), metastasis-free survival (MFS) (time to metastasis/death), time to castration resistance (CRPC), and death (OS); for mPC, outcome events included time from androgen deprivation start to CRPC and OS. BM status was descriptively summarized. Kaplan-Meier method and Cox regression model assessed associations of BM status with clinical outcomes. Results: Of the 237 men included, 16 (7%) were BM positive; 12 (6%) in 205 localized PC, 6 (14%) in 43 mPC. BM positive genes included 9 (4%) ATM, 6 (3%) BRCA2, and 2 (0.8%) CHEK2. In men with localized PC, EFS events occurred in 58% (7/12) BM positive vs 34% (66/193) BM negative at median follow up of 3.1 years; BM positive trended toward a shorter EFS (median 1.9 vs 5 years) than BM negative (HR 2.17, 95%CI 0.99-4.76). MFS events were observed in 17% (2/12) BM positive vs 7% (15/193) BM negative. CRPC events occurred in 17% (2/12) BM positive vs 6% (11/193) BM negative. In men with mPC, there were CRPC events in 100% (6/6) BM positive vs 67% (25/37) BM negative at median follow up of 3.3 years; BM positive trended toward a shorter time to CRPC (median 4 vs 8.8 months) compared to BM negative (HR 1.87, 95%CI 0.76-4.64). There was no association between BM status and OS. Conclusions: DDR variants appear infrequently in localized PC but may portend a shorter time to PSA relapse and metastasis. Similarly, DDR variants in mPC may be associated with a shorter time to CRPC. Low frequency of variants and short follow up limit these analyses. The prognostic value of DDR variants remains unclear and requires further research.

scholarly journals Nonmyeloablative allogeneic transplantation with or without 90yttrium ibritumomab tiuxetan is potentially curative for relapsed follicular lymphoma: 12-year results

Blood ◽  
2012 ◽  
Vol 119 (26) ◽  
pp. 6373-6378 ◽  
Author(s):  
Issa F. Khouri ◽  
Rima M. Saliba ◽  
William D. Erwin ◽  
Barry I. Samuels ◽  
Martin Korbling ◽  
...  
Keyword(s):  
Follicular Lymphoma ◽  
Survival Rates ◽  
Conditioning Regimen ◽  
Low Frequency ◽  
Progression Free Survival ◽  
Allogeneic Transplantation ◽  
Ibritumomab Tiuxetan ◽  
Free Survival ◽  
Innovative Strategies

In 2008, we reported favorable 5-year outcomes of nonmyeloablative allogeneic stem cell transplantation after fludarabine, cyclophosphamide, rituximab (FCR) conditioning for relapsed and chemosensitive follicular lymphoma. However, innovative strategies were still needed to treat patients with chemorefractory disease. We therefore subsequently performed a trial in which 90Y-ibritumomab tiuxetan (0.4 mCi/kg) was added to the fludarabine, cyclophosphamide conditioning regimen (90YFC). Here, we report updated results of the FCR trial and outcomes after 90YFC. For the FCR group (N = 47), since the last update, one patient developed recurrent disease. With a median follow-up of 107 months (range, 72-142 months), the 11-year overall survival and progression-free survival rates were 78%, and 72%, respectively. For the 90YFC group (N = 26), more patients had chemorefractory disease than did those in the FCR group (38% and 0%, P < .001). With a median follow-up of 33 months (range,17-94 months), the 3-year progression-free survival rates for patients with chemorefractory and chemosensitive disease were 80% and 87%, respectively (P = .7). The low frequency of relapse observed after a long follow-up interval of 9 years in the FCR group suggests that these patients are cured of their disease. The addition of 90Y to the conditioning regimen appears to be effective in patients with chemorefractory disease. This trial was registered at www.clinicaltrials.gov as NCT00048737.

scholarly journals Prognostic factors of cardiovascular death in patients with ischemic stroke in the long-term follow up

2016 ◽  
Vol 7 (3-4) ◽  
pp. 97-103
Author(s):  
A. V Fonyakin ◽  
L. A Geraskina ◽  
V. A Shandalin
Keyword(s):  
Ischemic Stroke ◽  
Sinus Rhythm ◽  
Recurrent Stroke ◽  
Low Frequency ◽  
Holter Monitoring ◽  
Multivariate Regression Analysis ◽  
Cardiovascular Death ◽  
Increased Risk ◽  
Two Parameters

In a prospective observational non-interventional study included 148 patients with ischemic stroke at the age of 60 (52; 68) years, with sinus rhythm. At the end of the acute stroke period (21-22 days) was performed Holter monitoring with the assessment of arrhythmias and heart rate variability (HRV). Duration of prospective follow-up was 35 (28; 40) months. We register all cases of cardiovascular death (CD), including death due to recurrent stroke, myocardial infarction (MI), sudden CD (SCD), acute heart failure (AHF), pulmonary embolism. During follow up CD was registered in 15 (10%) patients: in 7 patients - due to recurrent stroke, 2 patients - due to acute MI, in 3 - due to AHF, 3 patients - due to SCD. On multivariate regression analysis in sinus rhythm revealed significant association with the development of CD following factors: age over 67 years, male gender, involvement insula in the area of ischemic damage, supraventricular extrasystoles (more than 54 extrasystoles per day), ventricular arrhythmias, bradyarrhythmias, reduced power range of high-frequency (HF) less than 39 ms2 and low frequency less than 180 ms2 HRV. Separately from the number of these factors with increased risk of fatal complications was significantly associated only two parameters: the involvement insula in the cerebral infarct area (p

scholarly journals SIX-MONTH FOLLOW-UP OF THE EFFECT OF A MAGNETIC FIELD ON CEREBRAL MOTOR DISORDERS IN EARLY CHILDHOOD

2021 ◽  
Vol 9 (06) ◽  
pp. 543-548
Author(s):  
V. K. Kostova ◽  
◽  
A. Aleksiev ◽  
Keyword(s):  
Magnetic Field ◽  
Statistical Significance ◽  
Low Frequency ◽  
Motor Disorders ◽  
Cranial Ultrasound ◽  
Short Term ◽  
Primitive Reflexes ◽  
Frequency Impulse

Introduction:- There is a consensus about the short-term efficacy, but not about the long-term effect of the low-frequency impulse magnetic field in early childhood cerebral motor disorders. There is no consensus about the statistical significance of the two-week and six-month dynamics of the kinesiology tests, cranial ultrasound, pathological and primitive reflexes. Objective:- To compare the short-term and long-term effect of the low-frequency impulse magnetic field versus placebo control and compare the statistical significance regarding the two-week and six-month dynamics of the kinesiology tests, cranial ultrasound, pathological and primitive reflexes. Material and Methods:- 29 children (age 8.10 ± 5.98 months) with cerebral motor disorders were followed for 6 months. They were divided into two groups - physiotherapeutic and control. The physiotherapy group (n = 14) received a once-daily low-frequency impulse magnetic field for two weeks at the start of the follow-up. The control group (n = 15) received a once-daily placebo magnetic therapy for two weeks at the start of the follow-up. Kinesiology tests, cranial ultrasound, pathological and primitive reflexes were recorded at the beginning of the follow-up, after two weeks, and after six months. Results:- At the beginning of the follow-up, there was no difference between the two groups regarding all parameters (P>0.05). Both groups showed better results after two weeks versus the start of the follow-up (P<0.05) and after six months versus after two weeks (P<0.05). The physiotherapy group showed better results versus the control group after the second week (P<0.05) and after the sixth month (P<0.05). The two-week and six-month dynamics of the kinesiology tests showed the highest significance (P<0.001), followed by primitive reflexes (P<0.04), followed by pathological reflexes (P<0.05), and finally - the cranial ultrasound (P>0.05), at comparable baseline parameters (P<0.05). Conclusion:- The low-frequency impulse magnetic field showed a significant short-term and long-term therapeutic effect that exceeded the corresponding placebo effects. The statistical significance at the second week and the sixth month of kinesiology tests was the highest, followed by primitive reflexes, and pathological reflexes. The cranial ultrasound did not show significant two-week and six-month dynamics. Despite the relatively stationary morphological changes, verified by cranial ultrasound, the developing nervous system in children aged 8.10 ± 5.98 months showed significant positive dynamics and plasticity for two weeks and six months, verified by kinesiology tests, primitive and pathological reflexes.

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