Removal of residual bubble nuclei to enhance histotripsy soft tissue fractionation at high rate

2014 ◽  
Vol 136 (4) ◽  
pp. 2280-2280
Author(s):  
Alexander P. Duryea ◽  
Charles A. Cain ◽  
William W. Roberts ◽  
Timothy L. Hall
Keyword(s):  
Soft Tissue ◽  
High Rate ◽  
Tissue Fractionation

Myxofibrosarcoma: clinical and prognostic value of MRI features

2020 ◽  
Vol 16 ◽  
Author(s):  
Paolo Spinnato ◽  
Andrea Sambri ◽  
Tomohiro Fujiwara ◽  
Luca Ceccarelli ◽  
Roberta Clinca ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Local Recurrence ◽  
Contrast Enhancement ◽  
Imaging Modality ◽  
Soft Tissue Sarcomas ◽  
The Elderly ◽  
High Rate ◽  
Imaging Features ◽  
High Grade ◽  
Mri Features

: Myxofibrosarcoma is one of the most common soft tissue sarcomas in the elderly. It is characterized by an extremely high rate of local recurrence, higher than other soft tissue tumors, and a relatively low risk of distant metastases.Magnetic resonance imaging (MRI) is the imaging modality of choice for the assessment of myxofibrosarcoma and plays a key role in the preoperative setting of these patients.MRI features associated with high risk of local recurrence are: high myxoid matrix content (water-like appearance of the lesions), high grade of contrast enhancement, presence of an infiltrative pattern (“tail sign”). On the other hand, MRI features associated with worse sarcoma specific survival are: large size of the lesion, deep location, high grade of contrast enhancement. Recognizing the above-mentioned imaging features of myxofibrosarcoma may be helpful to stratify the risk for local recurrence and disease-specific survival. Moreover, the surgical planning should be adjusted according to the MRI features

scholarly journals Surgical outcome with single stage procedure for neglected congenital talipes equinovarus

2019 ◽  
Vol 6 (1) ◽  
pp. 37
Author(s):  
Vishal H. Chandak ◽  
Ketan J. Khatri ◽  
Shraddha H. Chandak
Keyword(s):  
Developing Countries ◽  
Soft Tissue ◽  
Single Stage ◽  
High Rate ◽  
Prolonged Treatment ◽  
Soft Tissue Release ◽  
Wedge Osteotomy ◽  
Congenital Talipes Equinovarus ◽  
Talipes Equinovarus ◽  
Congenital Talipes

<p class="abstract"><strong>Background:</strong> Congenital talipes equinovarus is one of the commonest congenital anomalies. In developing countries like India especially in the rural population still there are many myths, culture and awareness issues regarding this deformity. Many patients get initial treatment with casting but tend loose follow ups in this prolonged treatment. To give optimal results in these scenarios, the technique for single stage procedure which includes bony and soft tissue repair gives excellent results.</p><p class="abstract"><strong>Methods:</strong> In a retrospective longitudinal study, 13 children with neglected clubfeet were involved. Valid consent, clinical and radiological evaluation was done. Patients underwent single stage (bony and soft tissue) procedure described in the study. Post operatively data was collected and scoring was done as per International clubfoot study group (ICSG) at each follow ups.<strong></strong></p><p class="abstract"><strong>Results:</strong> A total 13 children out of whom 9 were male and 4 females, all having unilateral deformity were studied. The age group was between 5-22 years (mean 13.5). Postoperatively, the children were followed at 6 months intervals. As per ICSG score 10 patients had excellent results, 3 patients had good results and none had poor results. 2 patients had minor complication - delayed wound healing (2-3 weeks).</p><p class="abstract"><strong>Conclusions:</strong> Treatment of neglected clubfoot using single stage procedure dorsal close wedge osteotomy with soft tissue release has a high rate of good and excellent results, with low frequency of complications. It is a good alternative to conventional procedures for management of neglected clubfeet in developing countries, where compliance of patient is a problem.</p>

High Shear Rate Behavior of Gelatin

2010 ◽  
Author(s):  
Jiwoon Kwon ◽  
Ghatu Subhash
Keyword(s):  
Soft Tissue ◽  
Mechanical Deformation ◽  
High Rate ◽  
Systematic Evaluation ◽  
Strain Rates ◽  
High Shear ◽  
Considerable Effort ◽  
Rate Behavior ◽  
High Rate Loading ◽  
Biomedical Fields

Gelatin is popular tissue simulant due to their biocompatibility and hence commonly used as surrogates for soft tissue in biomedical fields. With increased focus on tissue damage from battle field, considerable effort is being placed on modeling the mechanical deformation of soft tissue under high rate loading. Systematic evaluation of properties of such surrogate materials is required at similar strain rates because studies using real tissue are always not practical.

scholarly journals Rare Adult Subtype of Rhabdomyosarcoma, a Common Childhood Soft Tissue Carcinoma

2021 ◽  
Vol 9 ◽  
pp. 232470962110422
Author(s):  
Manasa Dondapati ◽  
Jonathan Vincent M. Reyes ◽  
Saad Ahmad ◽  
Aaron S. Stern ◽  
Joseph J. Lieber
Keyword(s):  
Soft Tissue ◽  
Treatment Guidelines ◽  
Pediatric Population ◽  
Adult Population ◽  
Survival Rates ◽  
Alveolar Rhabdomyosarcoma ◽  
High Rate ◽  
Childhood And Adolescence ◽  
Advanced Stages ◽  
Poorly Differentiated

Rhabdomyosarcoma is a malignant soft tissue sarcoma of primitive mesenchymal cells, showing varying degrees of striated skeletal muscle cell differentiation. It is a very common cancer of childhood and adolescence, but rarely seen in the adult population. Here, we present a case of a 33-year-old male presented with a poorly differentiated desmin positive alveolar rhabdomyosarcoma in the left arm. The prognosis of alveolar rhabdomyosarcoma in adults is very poor, frequently detected at advanced stages or with metastases. The alveolar subtype in particular has been found to have a more aggressive course with a high rate of metastasis. Recent studies have shown that using pediatric treatment guidelines resulted in better survival outcomes and local control, but the survival rates are still below that of the pediatric population. Newer studies are looking into using specific molecular markers for more targeted therapy in hopes of further improving survival rates in the adult population.

scholarly journals Myxoinflammatory Fibroblastic Sarcoma: Review and Update

2017 ◽  
Vol 141 (11) ◽  
pp. 1503-1507 ◽  
Author(s):  
David R. Lucas
Keyword(s):  
Soft Tissue ◽  
Local Recurrence ◽  
Soft Tissue Tumor ◽  
High Rate ◽  
High Grade ◽  
Clinicopathologic Features ◽  
Molecular Features ◽  
Microscopic Features ◽  
Myxoinflammatory Fibroblastic Sarcoma ◽  
Low Rate

Myxoinflammatory fibroblastic sarcoma is a rare soft tissue tumor with most occurring in the distal extremities of adult patients. It has a high rate of local recurrence and a low rate of metastasis. Because it may appear benign on clinical examination, and because the microscopic features are generally underrecognized, it is often inadequately treated and misdiagnosed. In this review, based upon experience and that of the literature, the intent is to highlight salient clinicopathologic features, detail the broad microscopic spectrum including high-grade aggressive variants, review the molecular features, and discuss its relation to hemosiderotic fibrolipomatous tumor.

scholarly journals Dermatofibrosarcoma Protuberans: Insights into a Rare Soft Tissue Tumor

2016 ◽  
Vol 6 ◽  
pp. 16 ◽  
Author(s):  
Aliya Sarhan Al Barwani ◽  
Sawsan Taif ◽  
Reem Ahmed Al Mazrouai ◽  
Khamis Salim Al Muzahmi ◽  
Asif Alrawi
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Tumor ◽  
Clinical Presentation ◽  
Treatment Options ◽  
Dermatofibrosarcoma Protuberans ◽  
High Rate ◽  
Imaging Findings ◽  
Full Extent ◽  
Radiological Appearance ◽  
Characteristic Features

Dermatofibrosarcoma protuberans (DFSP) is a rare soft tumor which originally represents a cutaneous sarcoma. It grows slowly and presents usually as nodular superficial lesion on the trunk or the extremities. Although these tumors are locally aggressive with high rate of recurrence following surgery; the prognosis is considered excellent when it is effectively treated. The radiological appearance of this tumor has rarely been studied and findings infrequently discussed in the literature probably because many lesions underwent resection before imaging. Although imaging is infrequently performed for this lesion; it can show characteristic features and demonstrate the full extent. Imaging may also play a role in the differentiation of this tumor from more serious soft tissue lesions such as more aggressive sarcomas and hemangioma. In this article, we discuss the imaging findings of DFSP that can aid in its diagnosis and its variable appearances. In addition; the clinical presentation and treatment options are also described with review of the previous literature.

Affect of Attachment Site on Medial Patellofemoral Ligament Reconstruction: A Finite Element Analysis

2013 ◽  
Author(s):  
Nicole A. DeVries ◽  
Matthew J. Bollier ◽  
Nicole M. Grosland
Keyword(s):  
Soft Tissue ◽  
Patellar Dislocation ◽  
Medial Patellofemoral Ligament ◽  
Attachment Site ◽  
High Rate ◽  
Trochlear Groove ◽  
Element Analysis ◽  
Lateral Patellar Dislocation ◽  
Bony Anatomy ◽  
Patellar Stability

Bony anatomy, soft tissue restraints, and the dynamic action of the quadriceps all play a role in maintaining patellar stability throughout knee motion. The medial patellofemoral ligament (MPFL) is the main soft tissue restraint to lateral translation of the patella, and helps guide the patella into the trochlear groove during the first 30° of knee flexion [1]. Studies have shown that the MPFL is the most consistently injured anatomical structure after acute lateral patellar dislocation [2]. Due to the high rate of recurrent episodes of instability following conservative management of acute lateral patellar dislocation, a number of bony and soft tissue procedures have been described to restore patellar stability, including MPFL reconstruction [2].

Extra-abdominal Desmoid Fibromatosis in the Foot

2011 ◽  
Vol 101 (1) ◽  
pp. 70-74 ◽  
Author(s):  
Alan A. MacGill ◽  
Vincent R. Milione ◽  
Laura G. Sullivan
Keyword(s):  
Soft Tissue ◽  
Clinical Evidence ◽  
Surgical Excision ◽  
Wide Excision ◽  
High Rate ◽  
Desmoid Tumors ◽  
Surrounding Soft Tissue ◽  
Desmoid Fibromatosis ◽  
Extra Abdominal Desmoid ◽  
Local Surgical Excision

Extra-abdominal desmoid tumors account for 0.03% of all neoplasms and rarely present in the foot. They are benign but locally aggressive, and wide local surgical excision is the treatment of choice owing to the high rate of recurrence in the lower extremities. Invasiveness into the surrounding soft-tissue structures often makes wide excision difficult without compromise of function. We describe a 34-year-old woman with a large, pedal, extra-abdominal desmoid fibroma treated by wide local surgical excision with minimal complications postoperatively and no clinical evidence of recurrence at 28 months. (J Am Podiatr Med Assoc 101(1): 70–74, 2011)

scholarly journals The Early Adhesion Effects of Human Gingival Fibroblasts on Bovine Serum Albumin Loaded Hydrogenated Titanium Nanotube Surface

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5229
Author(s):  
Yuchen Sun ◽  
Ran Lu ◽  
Jingming Liu ◽  
Xin Wang ◽  
Haitao Dong ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Soft Tissue ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Human Gingival Fibroblasts ◽  
High Rate ◽  
Gingival Fibroblasts ◽  
Normal Loading ◽  
Initial Adhesion

The soft tissue sealing at the transmucal portion of implants is vital for the long-term stability of implants. Hydrogenated titanium nanotubes (H2-TNTs) as implant surface treatments were proved to promote the adhesion of human gingival fibroblasts (HGFs) and have broad usage as drug delivery systems. Bovine serum albumin (BSA) as the most abundant albumin in body fluid was crucial for cell adhesion and was demonstrated as a normal loading protein. As the first protein arriving on the surface of the implant, albumin plays an important role in initial adhesion of soft tissue cells, it is also a common carrier, transferring and loading different endogenous and exogenous substances, ions, drugs, and other small molecules. The aim of the present work was to investigate whether BSA-loaded H2-TNTs could promote the early adhesion of HGFs; H2-TNTs were obtained by hydrogenated anodized titanium dioxide nanotubes (TNTs) in thermal treatment, and BSA was loaded in the nanotubes by vacuum drying; our results showed that the superhydrophilicity of H2-TNTs is conducive to the loading of BSA. In both hydrogenated titanium nanotubes and non-hydrogenated titanium nanotubes, a high rate of release was observed over the first hour, followed by a period of slow and sustained release; however, BSA-loading inhibits the early adhesion of human gingival fibroblasts, and H2-TNTs has the best promoting effect on cell adhesion. With the release of BSA after 4 h, the inhibitory effect of BSA on cell adhesion was weakened.

Assessment of viable cells as a predictor of response in soft tissue sarcomas treated with neoadjuvant therapy.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e21507-e21507
Author(s):  
Ranyell Spencer Sobreira Batista ◽  
Samuel Aguiar ◽  
Isabela Werneck Cunha ◽  
Ademar Lopes ◽  
Fernando A. Soares ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Tumor Necrosis ◽  
Survival Rates ◽  
Soft Tissue Sarcomas ◽  
Disease Free Survival ◽  
Viable Cell ◽  
High Rate ◽  
High Grade ◽  
Response Parameter ◽  
Viable Cells

e21507 Background: Soft Tissue Sarcomas (STS) are an uncommon neoplasm with many histological subtypes with different behaviors, response to treatments and developments. The treatment of these tumors is using surgery, radiotherapy or chemotherapy. The pathological response using degree of tumor necrosis has been implicated in survival rates. However comes to assessing the degree of tumor necrosis in the surgical specimens as response parameter could be confuse because the high-grade sarcomas exhibit a high rate of necrosis even without any treatment. Methods: 31 patients with STS of high grade located in extremities treated with neoadjuvant doxorubicin and ifosfamide were observed prospectively since January 2005 to June 2011. For evaluation of surgical specimens post neoadjuvant chemotherapy, a slice of the specimen in with lower gross of necrosis was represented and after mapped evaluating grade of necrosis, fibrosis and percentage of viable cells. Results: Six patients had ≤5% of viable cells, eight had ≤10% and 12 with 30% or less in the sample. Overall survival (OS) was 100%, 100% and 91% with Disease free survival (DFS) were 100%, 85.7% and 82.5%, respectively. No patient had ≥95% necrosis in the surgical specimens considering that a large part of the tissue had fibrosis in patients with few viable cells, which do not correlate with survival. Conclusions: The viable cell count in the sample is feasible, and relates well with survival. We consider this the ideal method for response evaluation in SPM instead of counting necrosis. In combination with the literature data we suggest cutoff points of 5%, 10% and 30%.

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